Myeloid-Derived Suppressor Cells as a Potential Biomarker and Therapeutic Target in COVID-19COVID-19에서 잠재적인 바이오마커 및 치료 표적으로서의 골수 유래 억제 세포Review Published on 2021-06-182022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] activating adaptive Biomarker Biomarkers Cell clinical Clinical presentations COVID-19 COVID-19 infection COVID-19 pneumonia defined disease disease course disease severity driving dysregulated dysregulation Evidence Host immune response immune activation immune responses Immunity immunology impair innate immune cell lymphocyte lymphocyte counts MDSC mechanism mediators myeloid cell pathophysiology Patient Pneumonia Potential pro-inflammatory state promote recruitment resulting secretion severe COVID-19 shown Spectrum suppressor suppressor cells survival T-cell Response T-cell responses target therapeutic target therapeutic targets turn virus [DOI] 10.3389/fimmu.2021.697405 PMC 바로가기 [Article Type] Review
Declining Levels of Neutralizing Antibodies Against SARS-CoV-2 in Convalescent COVID-19 Patients One Year Post Symptom Onset증상 발병 1년 후 회복기 COVID-19 환자에서 SARS-CoV-2에 대한 중화 항체 수준 감소Immunology Published on 2021-06-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] Against antibody Antibody Response Antibody responses B.1.351 collected concerning convalescent patient Convalescent patients coronavirus disease Coronavirus disease 2019 COVID-19 declining detectable donors E484K fraction Humoral immunity IgG antibodies IgG titers IgM and IgG immune responses individual Infection Kinetics knowledge Level long-term immune response long-term immune responses Major natural infection neutralization test neutralization tests neutralize Neutralizing Neutralizing activity nucleocapsid Onset Patient patients performed PROTECT Protein quantified RBD Receptor binding domain recognizing recovered patient recovered patients SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG South Africa specific IgG antibodies spike Spike protein symptom onset symptomatic symptomatic COVID-19 the spike protein vaccination Vaccinations variant virus VoC Year [DOI] 10.3389/fimmu.2021.708523 PMC 바로가기 [Article Type] Immunology
Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccineArticle Published on 2021-06-162022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] Activation Analysis Biomarker Cell dendritic cell differentially expressed domains eight facilitated Gene regulation in immune cells homology immune responses in vivo inactivated Inactivated vaccine increased expression Infectious Bronchitis Virus Innate immune cells lipid metabolism lysed maturation mRNA mRNA expression mRNA translation newcastle disease virus PLIN2 positive control Potential biomarker Protein protein level Proteins proteomic Proteomic analysis provide PSMB1 significantly stimulated Stimulation subject the vaccine upregulated Vaccine vaccine-induced immune responses Vaccines were assessed [DOI] 10.1038/s41598-021-89810-3 PMC 바로가기 [Article Type] Article
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 proteinSARS-CoV-2 NSP14 단백질에 의한 타고난 면역 반응의 번역 차단 및 회피423 Published on 2021-06-152022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘, [키워드] active site active sites activities acute respiratory syndrome acute respiratory syndrome coronavirus addition Antiviral antiviral proteins antiviral response causative agent caused complex conserved coronavirus COVID-19 COVID-19 pandemic Critical demonstrated ENhance evade ExoN Exoribonuclease Health Health crisis Host host antiviral responses Host immune response host immune responses host protein human coronaviruses IFN-I IFN-I responses immune evasion immune responses Infection inhibit inhibition activity inhibitor inhibitory innate immune response Innate immunity interferon interferon-stimulated gene interferon-stimulated genes ISGs mechanism nsp14 overcome Pathogenesis pathogenesis of SARS-CoV-2 pathogenic virus pathogenic viruses Pathogens previous study Protein Proteins replicate required respiratory reveal SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance subversion synthesis the SARS-CoV-2 translation translation inhibition translational type I interferon Viral viral pathogens virus replication viruses [DOI] 10.1073/pnas.2101161118 PMC 바로가기 [Article Type] 423
Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women임산부와 수유부에서 코로나19 mRNA 백신의 면역원성Article Published on 2021-06-152022-09-11 Journal: JAMA [Category] MERS, SARS, 변종, 진단, [키워드] antibody Antibody Response Antibody titers assays B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants binding binding and neutralizing antibodies binding domain Blood BNT162b2 breast milk CD4 CD8 T-cell response CD8 T-cell responses Cellular immune response Cord blood COVID-19 COVID-19 vaccine COVID-19 vaccine trials COVID-19 vaccines cross-reactive antibody enrolled enzyme enzyme-linked immunospot evaluate evaluated excluded exploratory Exploratory analysis Fever Follow-up functional Humoral and cellular immune responses IFN-γ immune responses immunogenic immunogenicity ImmunoSpot increased risk lactating lactating women Messenger RNA Moderna morbidity morbidity and mortality mRNA mRNA vaccine mRNA-1273 Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers nonpregnant outcome Pfizer-BioNTech Phase 3 Population pregnant pregnant women preserved prospective cohort study receipt reduced reported response SARS-CoV-2 B.1.1.7 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 variant SARS-CoV-2 variants Spike-specific T-cell responses T-cell Response T-cell responses the SARS-CoV-2 transported vaccination Vaccine vaccine dose Viral Viral variants were assessed white women [DOI] 10.1001/jama.2021.7563 PMC 바로가기 [Article Type] Article
Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfectionSARS-COV-2- 특이 적 CD4 반응의 관계 COVID-19 중증도 및 HIV-1 및 결핵 공동 감염의 영향Clinical Trial Published on 2021-06-152022-08-13 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 임상, 진단, [키워드] AIDS/HIV Antigen attributes CD4 Cellular immune response characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient COVID-19 patients COVID-19 severity decrease Disease progression disease severity expression flow cytometry Frequency function HIV-1 HLA-DR hospitalized COVID-19 patients humoral immune response humoral immune responses immune responses implication involved knowledge magnitude Mycobacterium tuberculosis Patient patients phenotype proliferation reduced relationship SARS Coronavirus SARS-CoV-2 severe disease skewed Support T cell T cell depletion T cell response T cells the SARS-CoV-2 Tuberculosis [DOI] 10.1172/JCI149125 PMC 바로가기 [Article Type] Clinical Trial
Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients강력한 SARS-CoV-2-특이적 T 세포 면역 및 낮은 아나필라톡신 수치는 COVID-19 환자의 경증 질병 진행과 상관관계가 있습니다Immunology Published on 2021-06-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] addition analyzed anaphylatoxin anaphylatoxin C3a Antibody titer Antibody titers Blood C5a caused CD4 CD8 cellular characterized clearance Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient disease severity elevated ELISA ELISPOT ELISpot assay evaluated flow cytometry healthy individual highest humoral immune response IFNγ IgG immune complex immune responses immunodominant indicate infected individuals Level Lymphocytes lymphopenia Mild mild infections mononuclear cell mononuclear cells Mortality neutralization ability neutralizing Abs Neutralizing activity nucleocapsid Patient patients peptide peptide pool peripheral Peripheral blood Peripheral blood mononuclear cells potent reduced respiratory Respiratory system robust SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-infected individuals SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody severe disease progression significantly specific antibodies Spike proteins T cell T cell immunity T cell response T cell responses T cells T lymphocyte Viral viral infection viral infections [DOI] 10.3389/fimmu.2021.684014 PMC 바로가기 [Article Type] Immunology
Immune age and biological age as determinants of vaccine responsiveness among elderly populations: the Human Immunomics Initiative research program노인 인구의 백신 반응성을 결정하는 면역 연령 및 생물학적 연령: 인간 면역학 이니셔티브 연구 프로그램New Study Published on 2021-06-122022-09-10 Journal: European Journal of Epidemiology [Category] MERS, 바이오마커, [키워드] absence age Aging-related diseases approach biochemical biological age Biomarker Biomarkers Cohort cohorts COVID-19 determinant determine Effectiveness Efficacy ENhance exploration genetics geographical location Health status Human Human Vaccines humoral humoral immune response hypothese hypotheses idea immune Immune aging immune responses Immunity immunomics Infectious disease Infectious diseases Influenza influenza- initiative joint methodological Non-communicable disease non-communicable diseases offered Older participant pathway pertussis vaccine pertussis vaccines phenotype phenotypic data plasma sample plasma samples pneumococcal population-based cohort populations predictability predictor Program prospective cohort Public public health representing Research SAME AS School selected subsequent Vaccine vaccine response vaccine responses Vaccine responsiveness [DOI] 10.1007/s10654-021-00767-z PMC 바로가기 [Article Type] New Study
Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset초기 T 세포 및 결합 항체 반응은 COVID-19 RNA 백신 효능 발병과 관련이 있습니다Article Published on 2021-06-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Adaptive immune response adaptive immune responses Analysis binding binding antibodies binding antibody BNT162b2 BNT162b2 vaccine clinical trials Cohort Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 research demonstrated detectable doses Efficacy element first dose glass healthcare worker hour immune responses Immunity Neutralizing Neutralizing activity Neutralizing antibodies Pfizer/BioNTech Phase III clinical trials primary endpoint receiving respiratory response responses RNA RNA vaccine RNA vaccines SARS-CoV-2 Severe acute respiratory syndrome single dose Support T cell T cells the vaccine undetectable vaccination Vaccine vaccine efficacy virus was performed with COVID-19 [DOI] 10.1016/j.medj.2021.04.003 PMC 바로가기 [Article Type] Article
Mucosal-associated invariant T cell responses differ by sex in COVID-19COVID-19에서 점막 관련 불변 T 세포 반응은 성별에 따라 다릅니다Article Published on 2021-06-112022-09-11 Journal: Med (New York, N.Y.) [Category] MERS, 유전자 메커니즘, 임상, 진단, [키워드] aerosol Affair airway Apoptosis biosafety level BSL-2 BSL-3 carried Cell cells from male circulating construction content contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 sample COVID-19 samples COVID-19 susceptibility DARPA dataset Duke early infection female females flow cytometry gene signature healthy control Hospitalized IL-7 immune response immune responses immunologically individual Innate immunity integration level 2 management mechanism monocyte mononuclear cell mononuclear cells outcomes Peripheral blood Peripheral blood mononuclear cells pro-apoptotic processed Protective Quality Quality assurance reduced reduction Regional Biocontainment Laboratory responsibility SARS-CoV-2 Sex sexual dimorphism sexual dimorphisms Single-cell RNA sequencing Support supported System T cell response tissue uninfected veteran Virology [DOI] 10.1016/j.medj.2021.04.008 PMC 바로가기 [Article Type] Article