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Rapid response flow cytometric assay for the detection of antibody responses to SARS-CoV-2

SARS-CoV-2에 대한 항체 반응 검출을 위한 신속한 반응 유세포 분석법

Original Article

Published on 2020-10-202022-09-10
Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, SARS, 변종, 진단, 치료기술,

[키워드] 293T cell ACE-2 adopted angiotensin antibodies Antibody Response Antibody responses approach blueprint CLIA coronavirus detect diagnostic early phase ELISA evaluated expressing flow cytometric flow cytometry highest IgG and IgM IgM antibody Laboratory nucleic acid pandemic patient sera PCR-confirmed provide quantification Quantitative Rapid robust SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2-infected patients SARS-CoV-2-specific antibodies sensitivity sera Serological assay serological test Serological tests serology specific antibodies specificity specimen Spike protein Spike-specific antibody spike-specific antibody response Spike-specific antibody responses Spread variant Viral viral infection viral infections were used while Zoonotic coronavirus
[DOI] 10.1007/s10096-020-04072-7 PMC 바로가기 [Article Type] Original Article

Accurate Diagnosis of COVID-19 by a Novel Immunogenic Secreted SARS-CoV-2 orf8 Protein

Research Article

Published on 2020-10-202022-10-29
Journal: mBio [Category] COVID-19, MERS, SARS,

[키워드] accessory gene acute respiratory syndrome addition antibody B cell response can be used cell culture supernatant characterized coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 patient COVID-19 patients current demonstrated Diagnosis diagnosis of COVID-19 diagnostic early diagnosis early stage facilitate IgA IgG IgG antibody IgM immunogenic Infection late stage novel ORF8 pandemic Patient Protein reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein secreted protein secretion sera serological test spike glycoprotein symptomatic and asymptomatic the SARS-CoV-2 the SARS-CoV-2 genome unique
[DOI] 10.1128/mBio.02431-20 PMC 바로가기 [Article Type] Research Article

Establishment of replication-competent vesicular stomatitis virus-based recombinant viruses suitable for SARS-CoV-2 entry and neutralization assays

Research Article

Published on 2020-10-172022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS,

Rabies virus-based COVID-19 vaccine CORAVAX™ induces high levels of neutralizing antibodies against SARS-CoV-2

Article

Published on 2020-10-162022-10-30
Journal: NPJ Vaccines [Category] COVID-19,

Comprehensive pathogen detection in sera of Kawasaki disease patients by high-throughput sequencing: a retrospective exploratory study

Research Article

Published on 2020-10-152022-10-28
Journal: BMC Pediatrics [Category] COVID-19,

Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome

COVID-19의 항인지질 항체는 항인지질 증후군에서 검출되는 항체와 다릅니다

Immunology

Published on 2020-10-152022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술,

[키워드] β₂-glycoprotein I activated Anti-phospholipid antibodies antibodies antibody Anticoagulant anticoagulation aPTT association Autoimmunity C reactive protein chemiluminescence Coagulopathy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients death detectable develop domain ELISA epitope epitope specificity evaluate GPI hypercoagulable Hypercoagulable state investigated large cohort leads Lupus lupus anticoagulant objective Organ failure Patient patients Prevalence prothrombin reported Result sera severe COVID-19 specificity syndrome tested thrombosis thrombotic Thrombotic events were used
[DOI] 10.3389/fimmu.2020.584241 PMC 바로가기 [Article Type] Immunology

Kinetics of Nucleo- and Spike Protein-Specific Immunoglobulin G and of Virus-Neutralizing Antibodies after SARS-CoV-2 Infection

Article

Published on 2020-10-132022-10-29
Journal: Microorganisms [Category] COVID-19,

SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus

Research Article

Published on 2020-10-122022-10-28
Journal: Wellcome Open Research [Category] COVID-19,

[키워드] 95%CI acute infection Biomarker biosafety Blood blood product blood sample Cell culture Clinical characteristics Cohort collected convalescent convalescent plasma COVID-19 COVID-19 case cycle threshold Cytopathic effect detect detectable determine did not produce Evidence Frequency handling help identify increase in infection risk Infectious virus inoculated Laboratory laboratory diagnosis Laboratory safety limitation literature review multivariable negativity NHS NHSBT occurred Odds ratio Patient patients with COVID-19 PCR PCR-positive performed Precaution Respiratory samples RNA RT-PCR SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 RNA sera serum sample severe disease subset symptom onset Transplant Viraemia Viral load Viral RNA virus isolation vRNA
[DOI] 10.12688/wellcomeopenres.16002.2 PMC 바로가기 [Article Type] Research Article

Experimental and in silico evidence suggests vaccines are unlikely to be affected by D614G mutation in SARS-CoV-2 spike protein

Brief Communication

Published on 2020-10-082022-10-04
Journal: NPJ Vaccines [Category] 변종,

Rapid Determination of SARS-CoV-2 antibodies using a bedside, point-of-Care, serological test

Research Article

Published on 2020-10-072022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS,

[키워드] Bedside chest imaging complementary COVID COVID-19 death Determination Diagnosis diagnostic diagnostics discharge General population high accuracy IgG IgM IgM/IgG immunological infected patients information material MONITOR negative onset of symptom onset of symptoms pandemic Patient patients hospitalized positive Practitioner Rapid Rapid test remained RT–PCR SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sensitivity sera Seroconversion Serological assay serological test serology Social distancing measure specificity subsequent symptom onset tested the SARS-CoV-2 value Ventilation
[DOI] 10.1080/22221751.2020.1826892 PMC 바로가기 [Article Type] Research Article