Identification of potential inhibitors of SARS-CoV-2 S protein–ACE2 interaction by in silico drug repurposing
Silico 약물 용도로 SARS-COV-2 S 단백질 -ACE2 상호 작용의 잠재적 억제제 확인
Research Article
[키워드] ACE2
acute respiratory syndrome
acute respiratory syndrome coronavirus
angiotensin
Angiotensin-converting enzyme
angiotensin-converting enzyme 2
approved
Asthma
Atypical pneumonia
binding
binding site
cause
chronic obstructive
chronic obstructive pulmonary disease
Compound
coronavirus
COVID-19
COVID-19 disease
criteria
death
docking score
drug
Drug repurposing
drugs targeting
evaluate
FDA
fexofenadine
formoterol
Frequency
generate
host cell
identification
in silico
in vitro
in vivo
Infection
inhibitor
inhibitors
inhibitors of SARS-CoV-2
Interaction
interaction site
internalization
ipratropium
molecular docking
Mortality
New coronavirus
obstructive pulmonary disease
PDB
PDB ID
performed
Pneumonia
protein S
pulmonary disease
RBD
receptor
Receptor binding domain
receptor site
Replication
reported
Research
residue
respiratory
respiratory infection
S protein
S1 subunit
SARS-CoV-2
SARS-CoV-2 protein
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
specialist
the S1 subunit
therapy
treat
Treatment
virus
were used
Wuhan
Wuhan, China
[DOI] 10.12688/f1000research.52168.2 PMC 바로가기 [Article Type] Research Article
[DOI] 10.12688/f1000research.52168.2 PMC 바로가기 [Article Type] Research Article