immune responses – Page 71 – Communicable Diseases Research

Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans

인간의 SARS-COV-2 변이체에 대한 AD26.COV2.S 백신의 면역 원성

Clinical Trial

Published on 2021-06-092022-08-13
Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단,

Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study: an observational cohort study of SARS-CoV-2 infection and vaccination in healthcare workers

SARS-COV-2 SEROCONVERSION (PASS) 연구의 전향 적 평가 : 의료 근로자의 SARS-COV-2 감염 및 예방 접종에 대한 관찰 코호트 연구

Study Protocol

Published on 2021-06-092022-09-01
Journal: BMC Infectious Diseases [Category] MERS, SARS, 진단,

[키워드] Affect Analysis Anti-spike antibody assessment Asymptomatic baseline clinical response Cohort Complete conducted coronavirus coronavirus disease Coronavirus disease 2019 CoV covariates COVID-19 COVID-19 disease COVID-19 disease course cross-reactivity cytokine production determine develop disease symptoms evaluate Frequency glycoprotein HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs HCWs healthcare healthcare worker HKU1 human coronavirus IgG antibodies IgM and IgG immune response immune responses Immune-response immunological individual Infection intensity Killer cell magnitude mononuclear cell natural natural killer cell NL63 number of infected Observational cohort study OC43 pandemic coronavirus participant pauci-symptomatic PBMCs peptide peptide pool performed Peripheral blood Peripheral blood mononuclear cells positive Prospective Prospective Study questionnaire receive respiratory Respiratory disease Respiratory illness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 PCR testing SARS-CoV-2 vaccination SARS-CoV-2 vaccine seroconvert serology analysis severe respiratory illness severity Spike proteins supplementary material Symptom T cell T cell activation T cell response T cell responses tested the SARS-CoV-2 the spike protein vaccination Vaccine viral respiratory with COVID-19
[DOI] 10.1186/s12879-021-06233-1 PMC 바로가기 [Article Type] Study Protocol

Gender Specific Differences in Disease Susceptibility: The Role of Epigenetics

Review

Published on 2021-06-082022-10-28
Journal: Biomedicines [Category] COVID-19,

[키워드] adverse effect adverse outcomes Autoimmune disease Autoimmune diseases Cancer cellular comparable complex complex diseases COVID-19 difference Diseases Effects Epidemiological study Epigenetic epigenetics escape genes examined explain female females Gender Gender bias Hypothesis immune response immune responses immune system inactivation increasingly Infection Infectious diseases majority male males mechanism miRNA morbidity neurodegenerative outcome Pathogens reported respond role SARS-COV-2 infection Sex skewed skewed X inactivation Specific susceptibility the SARS-CoV-2 vaccination vaccination outcomes women X chromosome xenobiotics
[DOI] 10.3390/biomedicines9060652 PMC 바로가기 [Article Type] Review

Broad Severe Acute Respiratory Syndrome Coronavirus 2 Cell Tropism and Immunopathology in Lung Tissues From Fatal Coronavirus Disease 2019

광범위한 중증 급성 호흡기 증후군 코로나바이러스 2 치명적인 코로나바이러스 질병 2019에서 폐 조직의 세포 친화성 및 면역병리학

Article

Published on 2021-06-042022-09-11
Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ACE2 ACE2-positive cell Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive alveolar alveolar damage angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Autopsy B cell B cells Cell cell tropism cells ciliated contributing to coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Cytotoxic T cells DAD Depletion Diffuse alveolar damage endothelial cells excessive inflammation exhibited expression fatal COVID-19 goblet IL-6 immune cells immune responses immunofluorescence immunofluorescence assay immunohistochemistry Immunosuppression infected cell infected cells Infection infiltrating immune cell infiltrating immune cells Inflammation inflammatory cell inflammatory cells Innate immune cells interleukin-6 Lineage lung lung parenchyma Lungs macrophages marker mechanism Monocytes MOST natural killer Neutrophils NK cells Patient performed positive Protein pulmonary symptom pulmonary symptoms reflected regulatory T cells respiratory SARS-CoV-2 SARS-CoV-2 cell severe acute respiratory syndrome Coronavirus staining T cell T cells T helper cells thromboemboli. Thromboembolism tissue tissue damage to define tropism Viral viral infection Viral protein Viral proteins viral tropism
[DOI] 10.1093/infdis/jiab195 PMC 바로가기 [Article Type] Article

Single dose of BNT162b2 mRNA vaccine against severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) induces neutralising antibody and polyfunctional T‐cell responses in patients with chronic myeloid leukaemia

중증 급성 호흡기 증후군 코로나 바이러스 -2 (SARS -COV -2)에 대한 BNT162B2 mRNA 백신의 단일 용량은 만성 골수 백혈병 환자에서 중화 항체 및 다항식 T- 세포 반응을 유도합니다.

Clinical Trial

Published on 2021-06-032022-08-13
Journal: British Journal of Haematology [Category] MERS, SARS, 임상, 진단, 치료제,

[키워드] acute respiratory syndrome addition anti‐Spike immunoglobulin G BNT162b2 BNT162b2 vaccine CD4 CD8 Cellular immune response chronic myeloid leukaemia clinically CML develop Dilution dose evaluated haematological malignancies haematological malignancy humoral Humoral and cellular immune responses immune response immune responses immunocompromised individual immunocompromised individuals immunogenicity Immunoglobulin Immunoglobulin G induce Infection inhibit injection kinase inhibitors lymphoid haematological malignancies medium Most patients mRNA vaccine myeloid leukaemia Neutralising Antibodies neutralising antibody neutralising antibody response nine of BNT162b2 Patient patients Pfizer‐BioNTech polyfunctional response polyfunctional responses raised receiving respiratory SARS‐CoV‐2 SARS‐CoV‐2 BNT162b2 SARS‐CoV‐2 BNT162b2 vaccine SARS‐CoV2 vaccine Seroconversion serum dilution Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus single dose solid and haematological malignancies solid tumour T‐cell T‐cell response targeted cancer treatment targeted cancer treatments the patient These data titre TKIs tyrosine tyrosine kinase inhibitor tyrosine kinase inhibitors vaccination Vaccine were assessed
[DOI] 10.1111/bjh.17568 PMC 바로가기 [Article Type] Clinical Trial

Clinical Characteristics and Survival Analysis in Frequent Alcohol Consumers With COVID-19

Nutrition

Published on 2021-06-022022-10-31
Journal: Frontiers in Nutrition [Category] COVID-19,

[키워드] acute respiratory syndrome addition Adults age alcohol anti-bacterial Anti-viral C-reactive protein clinical Cohort consumer Consumption coronavirus Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19-associated inflammation CRP death death rate demonstrated disease Disease progression females generate Health immune response immune responses increase in Infection infections Inflammation investigated lymphocyte male marker men mitigate monocyte neutrophil count Neutrophil-to-lymphocyte ratio no difference outcomes Patient patients with COVID-19 presenting reduction in Risk factors SARS-CoV-2 smoking syndrome women
[DOI] 10.3389/fnut.2021.689296 PMC 바로가기 [Article Type] Nutrition

Exploring SARS-COV-2 structural proteins to design a multi-epitope vaccine using immunoinformatics approach: An in silico study

면역정보학 접근법을 사용한 다중 에피토프 백신 설계를 위한 SARS-COV-2 구조 단백질 탐색: 실리코 연구

Article

Published on 2021-06-012022-09-11
Journal: Computers in biology and medicine [Category] SARS, 치료법,

[키워드] adjuvant allergenicity analyzed Antigen antigenicity Bioinformatics analysis chimeric China cholera toxin conducted CTL CTL epitope CTL epitopes CTxB cytotoxic T lymphocyte cytotoxic T lymphocytes docked effective envelope epitope Epitope prediction Epitopes evaluate FIVE flexible fused HTL immune response immune responses Immune simulation immunoinformatics in silico In silico cloning in vitro in vivo Interaction linkers membrane molecular molecular dynamics Multi-epitope vaccine N-terminal new virus nucleocapsid physicochemical predicted Proteins receptor reported researchers reverse vaccinology SARS-CoV-2 SARS-CoV-2 vaccines selected spread to Stage structural protein structural proteins T lymphocyte the vaccine TLR4 Toll-like receptor toll-like receptor 4 Toxicity Vaccine vaccine construct was performed
[DOI] 10.1016/j.compbiomed.2021.104390 PMC 바로가기 [Article Type] Article

An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19

인간 A549 폐 세포의 자가항원 프로필은 COVID-19에서 자가면역의 바이러스 및 숙주 병인 분자 특성을 나타냅니다

Article

Published on 2021-06-012022-09-12
Journal: Journal of autoimmunity [Category] MERS, SARS, 진단,

[키워드] A549 A549 cells activating Affect alteration alterations Apoptosis atlas attribute autoantibodies autoantigen Autoantigens Autoimmune Autoimmune disease Autoimmunity biogenesis caused CDK11A cellular changes in COVID COVID-19 degranulation Gene Expression Host human lung IL-12 immune responses induce lung lung cell membrane mitochondrial ribosomal proteins mitochondrial ribosome modify molecular mRNA metabolism NSP Platelet PLD3 PRKDC Protein provide PSAT1 RAB1A resource Resource. reveal ribonucleoprotein SARS-COV-2 infection Signaling significantly SLC2A1 target transcript translation Transport UBA1 UCHL1 unique USP7 Vesicle viral infection Viral protein viral replication
[DOI] 10.1016/j.jaut.2021.102644 PMC 바로가기 [Article Type] Article

JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy

JAK-STAT 경로 억제 및 COVID-19 치료에 미치는 영향

Review

Published on 2021-06-012022-09-11
Journal: Postgraduate medicine [Category] 유전자 메커니즘, 치료법,

[키워드] 3CL pro activated Activation adverse effects B cell Baricitinib clinical trial contrary COVID-19 COVID-19 patients COVID-19 therapy cytokine cytokine receptor cytokine signaling Cytokine storm dendritic cell dendritic cells determine Disease progression disease severity Efficacy effort endothelial cells envelope protein envelope proteins excessive inflammation Host hosts immune response immune responses implicated incidence of COVID-19 increase Inflammation Inflammatory marker inflammatory markers Inflammatory mediators inhibition inhibitor inhibitors Jak Jak-STAT JAK/STAT JAK/STAT pathway JAK/STAT signaling janus Janus kinase Lymphocytes macrophages mechanism membrane molecular Monocytes natural killer cell Natural killer cells nucleocapsid nucleus Phosphorylation Pneumocytes progression promote protease Proteases Protein recruitment reduce Regulatory Authorities regulatory authority required ruxolitinib SARS-CoV-2 SARS-COV-2 infection severity signaling cascade signaling cascades STAT STATs structural protein structural proteins supported suppressor suppressors survival T cell the disease Therapeutic strategies therapeutic strategy Tofacitinib translate Trigger tyrosine
[DOI] 10.1080/00325481.2020.1855921 PMC 바로가기 [Article Type] Review

Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates

2개의 새로운 아데노바이러스 매개된 COVID-19 백신 후보로 생쥐와 붉은털 원숭이의 프라임 부스트 백신 접종

Research Article

Published on 2021-06-012022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술,

[키워드] Adenovirus animals anti-RBD anti-S binding antibody candidate CD4 cells changes COVID-19 vaccine COVID-19 vaccines detectable dose-dependent manner elicit evaluated FIVE followed by full-length human adenovirus 49 vector IFN-γ IL-2 immune response immune responses Immunity immunization immunogenicity macaque macaques mice mice and non-human primates nCoV pathologic peptide peptides preparation prime-boost regimen prime-boost vaccination priming pseudovirus neutralizing antibody response rhesus macaque rhesus macaques SARS-CoV-2 spike protein simian adenovirus 23 vector Specific Spike protein T cell T-cell Response the vaccine trials vaccination Vaccine
[DOI] 10.1080/22221751.2021.1931466 PMC 바로가기 [Article Type] Research Article