Rationale for the Use of Radiation-Activated Mesenchymal Stromal/Stem Cells in Acute Respiratory Distress Syndrome급성 호흡곤란 증후군에서 방사선 활성화 중간엽 간질/줄기세포 사용의 근거Review Published on 2020-09-022022-09-11 Journal: Cells [Category] SARS, 비임상, [키워드] activated acute respiratory-distress syndrome alleviate Analysis Annexin annexin A1 ARDS breath caused Cell Cell therapy cells characteristic Combination conditions COVID-19 dramatic increase Exosome Exosomes experimental radiotherapy greater Hypothesis hypothetical hypoxia IMPROVE Inflammation intensive care intensive care unit life-threatening load mesenchymal cells Mesenchymal stem cells Metastasis mice microvesicle Microvesicles MSC MSCs Patient Pneumonia Protein Proteins proteomic Proteomic analysis Radiation radiobiology Radiotherapy rationale reduce released respiratory respiratory capacity SARS-CoV-2 secreted shown significant difference significantly stimulated Symptom the cells therapeutic strategy therapy transplantation Tumor [DOI] 10.3390/cells9092015 PMC 바로가기 [Article Type] Review
Proteomic analysis of Ascocotyle longa (Trematoda: Heterophyidae) metacercariaeArticle Published on 2020-09-012023-06-22 Journal: Molecular and biochemical parasitology [Category] 조류인플루엔자, [키워드] Fish-born pathogen helminth Heterophyiasis Mugil liza parasite Proteins [DOI] 10.1016/j.molbiopara.2020.111311
Potential of Ocular Transmission of SARS-CoV-2: A ReviewReview Published on 2020-09-012022-10-29 Journal: Vision [Category] COVID-19, [키워드] ACE2 addition analyzed carried cathepsin CD147 Cell conjunctivitis coronavirus COVID-19 CTSL datasets Evidence gene expression profile immunohistochemistry implication infect infect cell infected with SARS-CoV-2 Infection likelihood mechanism molecular mechanism nasal nasal epithelium ocular Ocular surface ocular transmission Potential Proteins recent replicates Retina review SARS-CoV-2 TMPRSS2 Transmission virus [DOI] 10.3390/vision4030040 PMC 바로가기 [Article Type] Review
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors †Chemistry Published on 2020-09-012022-10-31 Journal: Chemical Science [Category] COVID-19, [키워드] acting clinically compounds conserved coronavirus cysteine cysteine protease domain drug resistance drug target Ebselen FIVE functional Helicase identify in viral inhibit inhibit SARS-CoV-2 nsp13 outbreak pandemic physical predicted protease Protein Proteins reduce Replication Safe SARS-CoV-2 Stage transcription factor Treatment Virus life cycle virus replication [DOI] 10.1039/d0sc02646h PMC 바로가기 [Article Type] Chemistry
Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral targetResearch Article Published on 2020-08-282022-11-01 Journal: Science Advances [Category] COVID-19, MERS, [키워드] antiviral efficacy antiviral target AP2M1 cause conserved coronavirus COVID-19 Endoplasmic reticulum Host host protein Human immunodeficiency virus IAV in vitro in vivo influenza A virus Interaction mechanism MERS-CoV motif Mutation nuclear offer pandemic pathogenic virus Protein protein-protein interaction Proteins reveal SARS-CoV-2 targeting Viral proteins viral replication virus Zika virus ZIKV [DOI] 10.1126/sciadv.aba7910 PMC 바로가기 [Article Type] Research Article
COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host CellsArticle Published on 2020-08-272022-10-31 Journal: Genes [Category] COVID-19, MERS, [키워드] PCSK3 ACE2 allele allelic analyzed BSG caused Cell cells Clinical symptoms coding contribute COVID-19 COVID-19 patient COVID-19 patients database DPP4 examined Exome Frequency Genes genetic variability Genetic variant genetic variants Host host genetic variability Hypothesis Infection involved Missense mutation missense variant pathogen Protein Proteins public health emergency receptor SARS-CoV-2 SARS-COV-2 infection Sequencing severity significant difference statistically Support susceptibility the SARS-CoV-2 TMPRSS2 Variability variant variants viral entry [DOI] 10.3390/genes11091010 PMC 바로가기 [Article Type] Article
The recent outbreaks of human coronaviruses: A medicinal chemistry perspective인간 코로나바이러스의 최근 발생: 의약 화학 관점Review Published on 2020-08-272022-09-10 Journal: Medicinal research reviews [Category] MERS, 신약개발, 치료제, [키워드] animals antiviral agent Antiviral agents antivirals approved biochemical Brain cleaving CoV CoV infection COVID‐19 CoVs drug effort event focus functional heart Human human coronavirus humans include infect Infection intestinal kidney life cycle main protease inhibitors MERS MERS‐CoV Middle East Middle East respiratory syndrome Mild outbreak Perspective polyprotein polyproteins protease Proteases Proteins Replication respiratory RNA‐dependent RNA polymerase SARS‐CoV‐1 SARS‐CoV‐2 SARS‐CoV‐1 SARS‐CoV‐2 spike glycoprotein syndrome target therapy These viruses these viruses transmitted Vaccine Viral viral entry viral replication Viral RNA viruses [DOI] 10.1002/med.21724 PMC 바로가기 [Article Type] Review
SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional ConvergenceReview Published on 2020-08-202022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Accessory accessory protein affecting appear asymptomatic stage Biomedical research Characteristics clinical trial convergence coronavirus COVID-19 COVID-19 pandemic deaths Disease spectrum Divergence evaluated Factor feature Features functional Genome genomic Health homolog Human identity imperative infected case infecting long-lasting magnitude nucleotide ORF8 ORF8ab predict Protein Proteins SARS-CoV SARS-CoV-2 Seven Spread target therapeutic approaches Vaccine while [DOI] 10.3390/pathogens9090677 PMC 바로가기 [Article Type] Review
Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneityArticle Published on 2020-08-192022-10-04 Journal: Scientific Reports [Category] MERS, 변종, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome Amino acid Analysis analyzed angiotensin-converting enzyme 2 annotation arginine Asia Belgium Case fatality rate circulating coding sequence Complete Computational biology and bioinformatics conserved Coronavirus-2 COVID-19 pandemic Deletion domain effective England epidemiological data epitope Europe European Evolution Frame France Frequency genetic variants genetics Genome genome sequence genomic GISAID database globe heterogeneous implication Interaction Italy lysine Microbiology Mutation Netherlands neutralizing antibody North America nucleotide ORF10 ORF1ab ORF7a pandemic polyprotein Prophylaxis Protein Proteins RBD remained reported residue responsible RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 virus strain sequence Shanghai Spain Substitution the SARS-CoV-2 genome Variation Viral protein virus strains [DOI] 10.1038/s41598-020-70812-6 PMC 바로가기 [Article Type] Article
Progress in Developing Inhibitors of SARS-CoV-2 3C-Like ProteaseReview Published on 2020-08-182022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] 3CL pro acute respiratory syndrome adopted Antiviral antivirals applied caused cleavage cleaving coronavirus Coronavirus disease 2019 COVID-19 Developing drug design Drug discovery drug target ENCODE enzyme feasibility functional Genome Health High-resolution Infection inhibitor inhibitors M pro nonstructural proteins pandemic polyprotein Prevent processed Progress protease Protease inhibitor Proteases Protein protein structures Proteins SARS-CoV-2 Spread structures therapeutic option Vaccine viral genome viral outbreak Viral protein viral replication virus World Health Organization [DOI] 10.3390/microorganisms8081250 PMC 바로가기 [Article Type] Review