Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with 2019 Novel Coronavirus (SARS-CoV-2) InfectionCase Report Published on 2020-07-182022-10-31 Journal: Case Reports in Pediatrics [Category] COVID-19, [키워드] abdominal pain acute respiratory syndrome Admission advanced respiratory support albumin levels Altered mental status association BNP C-reactive protein cerebrospinal fluid children clinical Clinical practice coronavirus Critically ill CSF died disease dysfunction etiology feature Fever gastrointestinal complaints healthy Infection Inflammatory Inotropes intensive care Intravenous immunoglobulin mechanism Meningitis MIS-C New novel one patient Patient patients pediatric Pediatric patient peptide positive presenting Rash Respiratory failure SARS-CoV-2 SARS-COV-2 infection Shock Steroids syndrome tested the patient Tocilizumab Two patient United States [DOI] 10.1155/2020/8875987 PMC 바로가기 [Article Type] Case Report
Administration of Immunoglobulins in SARS-CoV-2-Positive Patient Is Associated With Fast Clinical and Radiological Healing: Case ReportMedicine Published on 2020-07-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Case report clinical Clinical course clinical trial conducted COVID 19 COVID-19 demonstrated Diseases Efficacy and safety exhibiting Hydroxychloroquine IgM Immunoglobulin improvement interstitial Patient Pentaglobin Pneumonia polyclonal positive radiological report reported SARS-CoV2 selected therapeutic efficacy therapy Tocilizumab treated Treatment [DOI] 10.3389/fmed.2020.00388 PMC 바로가기 [Article Type] Medicine
Recovery of COVID-19 acute respiratory distress syndrome with tocilizumab: successful outcome in two critically ill patientsCase Report Published on 2020-07-152022-10-31 Journal: Immunotherapy [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress administration antiviral therapy ARDS C-reactive protein COVID-19 Critically ill patient Cytokine storm syndrome effective therapy Effectiveness Hydroxychloroquine Hyperactivation hyperinflammation IL-6 immune system Immunotherapy lung damage mechanism monoclonal antibodies outcome pathology Pneumonia Result Ritonavir SARS-CoV-2 Septic shock Severe case severe pneumonia suggested Support syndrome Tocilizumab tocilizumab administration treat two COVID-19 patient [DOI] 10.2217/imt-2020-0154 PMC 바로가기 [Article Type] Case Report
Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. A Case ReportMedicine Published on 2020-07-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] absence acute respiratory distress affected Anosmia Case report children Colchicine combined treatment Complete complications of COVID-19 coronary aneurysm COVID-19 COVID-19 infection Diagnosis feature hemodynamic instability High dose immune immune response immunoglobulins infection with SARS-CoV-2 Inflammatory inflammatory process Kawasaki disease limit manifestation Methylprednisolone MIS-C myocarditis Patient report reported SARS-CoV-2 serology specific antibody suggested syndrome Tocilizumab virus with COVID-19 [DOI] 10.3389/fmed.2020.00428 PMC 바로가기 [Article Type] Medicine
Early Use of Tocilizumab May Prevent Clinical Deterioration in Select COVID-19 Patients: A Case SeriesAllergy/Immunology Published on 2020-07-142022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Administered anticipated ARDS caused clinical Clinical deterioration clinically coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients develop early phase hospital inhibitor interleukin-6 intubation mechanical ventilation morbidity and mortality observation outcome pandemic Patient patients patients with COVID-19 respiratory viral illness Sery severe acute respiratory syndrome coronavirus 2 severe COVID-19 shown syndrome the disease the patient Tocilizumab worsening [DOI] 10.7759/cureus.9187 PMC 바로가기 [Article Type] Allergy/Immunology
Cytokine Storm in COVID-19: The Current Evidence and Treatment StrategiesImmunology Published on 2020-07-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] “cytokine storm” acute respiratory syndrome antimalarial antimalarial agents approach cause caused cells Concentration contribute coronavirus coronavirus disease Corticosteroids COVID-19 COVID-19 patients current cytokine Cytokine storm death effective Evidence IL-6 IL-6 inhibitor immunoregulation indicate induce infiltration Intravenous immunoglobulin lung tissue Lymphocytes Macrophage Mortality outbreak pathogen pathologic feature patients with COVID-19 poor prognosis pro-inflammatory pro-inflammatory cytokines programmed cell death Protein Safe severely ill patient storm Strategy the cytokine storm Tocilizumab Treatment strategies [DOI] 10.3389/fimmu.2020.01708 PMC 바로가기 [Article Type] Immunology
Challenges in the Management of SARS-CoV2 Infection: The Role of Oral Bacteriotherapy as Complementary Therapeutic Strategy to Avoid the Progression of COVID-19Medicine Published on 2020-07-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] added age All the patient Antibiotics Bacterial bacteriotherapy challenge clinical condition coded cohorts of patient Combination comparable complementary COVID-19 COVID-19 disease diarrhea disorder evaluate Fever Gastrointestinal Gut gut-lung axis Hospitalized Host Hydroxychloroquine ICU infecting Inflammation intestinal epithelial cells Laboratory lactobacillus less lung involvement microbial flora Mortality Non-invasive oral oxygen support Oxygen therapy Pathologies Patient patients treated positive Prevalence Probiotic progression receiving required Respiratory failure risk role SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 Sex Strategy Stress subject supplemented group Symptom the gut-lung axis the patient therapeutic strategy therapy Tocilizumab transferred treated Treatment [DOI] 10.3389/fmed.2020.00389 PMC 바로가기 [Article Type] Medicine
Immunopathology of SARS-CoV-2 Infection: Immune Cells and Mediators, Prognostic Factors, and Immune-Therapeutic ImplicationsReview Published on 2020-07-062022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] “cytokine storm” Activation alteration Analysis antagonists blockers Blood purification cellular characterized Chloroquine Critical Cytokine storm Cytokines drugs Evolution glucocorticoid humoral IFN lambda IL-1 IL-6 immune Immune cell immune change immune reaction immune response immunoglobulins immunopathology Infection inflammatory parameters inhibitor inhibitors leukocyte lymphocyte mononuclear macrophage pathogen Prognostic factor Prognostic marker proliferation recruitment resistance mechanisms SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients stem cells subpopulations T lymphocyte the disease therapy TNF Tocilizumab variety virus [DOI] 10.3390/ijms21134782 PMC 바로가기 [Article Type] Review
Treatment of Severe COVID-19 with Tocilizumab Mitigates Cytokine Storm and Averts Mechanical Ventilation during Acute Respiratory Distress: A Case Report and Literature ReviewCase Report Published on 2020-07-032022-10-29 Journal: Tropical Medicine and Infectious Disease [Category] COVID-19, [키워드] “cytokine storm” acute phase reactant acute phase reactants acute respiratory distress administer ARDS blood draws C-reactive protein caused chose clinical status COVID-19 cytokine cytokine release Cytokine release syndrome Cytokine storm D-dimer declining discharged disease distress dosage early treatment Evidence ferritin highlight Hydroxychloroquine ICU IL-6 IL-6 antagonist IL-6 inhibitor IL-6 inhibitors IL-6 receptor improvement Inflammation inhibitor intubation literature male management Mechanical mechanical ventilation Mortality oxygen support pandemic Patient patients patients with COVID-19 Prevent progression report reported respiratory Respiratory Coronavirus Respiratory disease respiratory symptom review SARS-CoV-2 serum severe COVID-19 storm Support syndrome the patient therapeutic Therapeutic benefit therapeutic strategy therapy Tocilizumab treat treated Treatment ventilator Wuhan, China [DOI] 10.3390/tropicalmed5030112 PMC 바로가기 [Article Type] Case Report
Childhood Rheumatic Diseases and COVID-19 Pandemic: An Intriguing Linkage and a New HorizonInvited Review Published on 2020-07-012022-10-28 Journal: Balkan medical journal [Category] COVID-19, SARS, [키워드] acute respiratory distress acute respiratory syndrome age Asymptomatic cardiovascular disease caused children clinical feature Comorbidity Course COVID-19 death defined diabete disease disease course drug dry cough Effect fatigue Horizon Hydroxychloroquine hypertension Immunosuppressive treatment individual infect Intensive lack linkage male Multiorgan dysfunction New Novel coronavirus Older pandemic Patient pediatric Pediatric patient pediatrics Protective respiratory Respiratory failure rheumatic disease Rheumatic diseases rheumatology risk factor SARS virus severe disease course Symptoms syndrome the disease therapeutic Tocilizumab underlying disease unlikely viral infection virus [DOI] 10.4274/balkanmedj.galenos.2020.2020.4.43 PMC 바로가기 [Article Type] Invited Review