Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
530
Published on
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS,
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS,
[키워드] 95% CI
Activation
acute respiratory syndrome
Admission
analyzed
antibody
antiviral antibodies
association
biological sample
C4d
C5a
clinical
clinical trials
complement
Complement activation product
Complement inhibitor
complement system
complex
Control
coronavirus
coronavirus disease COVID-19
correlated
COVD-19
COVID-19
COVID-19 patient
COVID-19 patients
defined
detrimental
driven by
Evidence
ferritin
healthy blood donors
Hospital stay
Hospitalized
hospitalized patient
innate immune response
Innate immunity
kPa
lack
lectin pathway
Local
majority
morbidity
Mortality
need for oxygen
new SARS-CoV-2
occur
Odds ratio
overactivation
pandemic
pathway
Patient
patients
PCR
prospective cohort study
provide
respiratory
Respiratory failure
SARS-CoV-2
SC5b-9
serology
Significance
significantly
significantly higher
systemic
systemically
Therapeutic approach
therapy
Treatment
Viral load
[DOI] 10.1073/pnas.2010540117 PMC 바로가기 [Article Type] 530
[DOI] 10.1073/pnas.2010540117 PMC 바로가기 [Article Type] 530