1 H, 13 C, and 15 N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3bArticle Published on 2020-08-142022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] addition ADP-ribose ADP-ribosylation Analysis Anti-viral apo form backbone catalytic activity catalyzed complex conserved COVID19-NMR domain drug target ENCODE form Host host immune system immune response in viral independent inhibitor International macrodomain MERS-CoV Modification modulating NMR non-structural protein Papain-like protease PARPs polymerase PROTECT Protein Protein drugability Proteins Replication RNA SARS-CoV SARS-CoV-2 SARS-CoV-2 genome secondary structure Solution NMR-spectroscopy suggested the SARS-CoV-2 triggered turn Viral protein viral replication virus [DOI] 10.1007/s12104-020-09973-4 PMC 바로가기 [Article Type] Article
1 H, 13 C, and 15 N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3bArticle Published on 2020-08-142022-10-27 Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, SARS, [키워드] addition ADP-ribose ADP-ribosylation Analysis Anti-viral apo form backbone catalytic activity catalyzed complex conserved COVID19-NMR domain drug target ENCODE form Host host immune system immune response in viral independent inhibitor International macrodomain MERS-CoV Modification modulating NMR non-structural protein Papain-like protease PARPs polymerase PROTECT Protein Protein drugability Proteins Replication RNA SARS-CoV SARS-CoV-2 SARS-CoV-2 genome secondary structure Solution NMR-spectroscopy suggested the SARS-CoV-2 triggered turn Viral protein viral replication virus [DOI] 10.1007/s12104-020-09973-4 PMC 바로가기 [Article Type] Article
1 H, 13 C, and 15 N backbone chemical shift assignments of the nucleic acid-binding domain of SARS-CoV-2 non-structural protein 3eArticle Published on 2020-08-082022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] backbone caused classical complex Consensus COVID-19 COVID19-NMR domain element ENCODE Host independent inhibitor interactions Lung disease NMR non-structural protein Nucleic acid-binding domain pandemic Papain-like protease Proteases Protein drugability Proteins Research respiratory RNA SARS-CoV-2 SARS-CoV-2 genome secondary structure Solution NMR-spectroscopy Support the Betacoronavirus the SARS-CoV-2 Viral RNA [DOI] 10.1007/s12104-020-09971-6 PMC 바로가기 [Article Type] Article
1 H, 13 C, and 15 N backbone chemical shift assignments of the nucleic acid-binding domain of SARS-CoV-2 non-structural protein 3eArticle Published on 2020-08-082022-10-27 Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, SARS, [키워드] backbone caused classical complex Consensus COVID-19 COVID19-NMR domain element ENCODE Host independent inhibitor interactions Lung disease NMR non-structural protein Nucleic acid-binding domain pandemic Papain-like protease Proteases Protein drugability Proteins Research respiratory RNA SARS-CoV-2 SARS-CoV-2 genome secondary structure Solution NMR-spectroscopy Support the Betacoronavirus the SARS-CoV-2 Viral RNA [DOI] 10.1007/s12104-020-09971-6 PMC 바로가기 [Article Type] Article
Assay validation and determination of in vitro binding of mefloquine to plasma proteins from clinically normal and FIP-affected catsResearch Article Published on 2020-08-052022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Accuracy antimalarial Antiviral average binding calicivirus clinical trial clinically coefficient Concentration coronavirus demonstrated detect dialysis dosing regimens expressed in vitro in vivo infections inhibit investigated limit plasma plasma concentration plasma protein Plasma Protein Binding Population Precision proportion Proteins quantification reported Standard deviation Variation [DOI] 10.1371/journal.pone.0236754 PMC 바로가기 [Article Type] Research Article
Phosphate Derivatives of 3-Carboxyacylbetulin: SynThesis, In Vitro Anti-HIV and Molecular Docking StudyArticle Published on 2020-08-052022-10-28 Journal: Biomolecules [Category] COVID-19, [키워드] anti-HIV bevirimat C-terminal domain comparable Compound CTD derivative docking docking score effective Gag HIV-1 in silico in vitro inhibit inhibitor inhibitors inhibitory concentration Interaction intrinsically Ligand maturation molecular target pentacyclic peptide phosphate Protein Proteins SARS-CoV-2 SARS-CoV2 selective SP1 therapy triterpenes viral infections viral replication was used [DOI] 10.3390/biom10081148 PMC 바로가기 [Article Type] Article
Network Pharmacology Integrated Molecular Docking Reveals the Mechanism of Anisodamine Hydrobromide Injection against Novel Coronavirus PneumoniaResearch Article Published on 2020-08-052022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Analysis analyzed angiotensin-converting enzyme 2 Anisodamine Cancer caused cell death China coronavirus COVID-19 Cytoscape disease Gene ontology immune system immune system diseases IMPROVE in viral infections ingredient injection Interaction interactions Intersection investigated KEGG material mechanism of action molecular docking Molecular docking study network novel coronavirus pneumonia Ontology outbreak parameters pathway pathway enrichment patients with COVID-19 performed pharmacological Pharmacology Protein Protein target Proteins provide regulate Result SARS-CoV-2 screened signaling pathways STRING database target targets tested therapeutic target were used with COVID-19 Wuhan, China [DOI] 10.1155/2020/5818107 PMC 바로가기 [Article Type] Research Article
PROTECT Trial: A cluster-randomized study with hydroxychloroquine versus observational support for prevention or early-phase treatment of Coronavirus disease (COVID-19): A structured summary of a study protocol for a randomized controlled trialStudy Protocol Published on 2020-07-312022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 24 hour addition Administered adverse event all subject allocation sequence Analysis antiviral activity Antiviral effect Arm arrhythmia Asymptomatic bradycardia can be used carried Cell Chronic kidney disease clinical Cluster Clusters Comorbidity Compliance conducted congestive heart failure Contact contraindication Coronaviruses covariates COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 symptom Data monitoring committee database deficiency defined Department diabete diagnostic dialysis disease dissemination diuretics dose drug Drug-drug interactions during treatment early treatment Efficacy element eligible endosomal pH ENhance enrolled Epidemic Epidemiology equation EudraCT evaluate Evidence expected Factor female Final G6PD Generalized generate Glucose-6-phosphate glycosylation group Healthcare professional Hydroxychloroquine hydroxychloroquine/chloroquine identify in vitro in vivo inclusion criteria independent index index case index cases Infection interim analysis involved IRCCS ischemic heart disease Italian region Italy Loading dose male malignancy medication mental illness mild symptoms neurological number objective observation open label oropharyngeal swab outcome parallel group participant Patient patients with COVID-19 Paucisymptomatic performed positive PCR test Prevent prevention prevention of COVID-19 Prophylaxis proportion Proteins protocol protocol amendment Public QT prolongation randomization Randomized Randomized controlled clinical trial Randomized controlled trial reached receive recorded recruited reduced reduction in Registered reported required risk Sample size SARS-CoV-2 shown Standard status stratified Studio Study protocol subject subjects Support Swab Symptom symptomatic syndrome Tablet therapeutic approaches therapy Toxicity treat treated Treatment Trial trial protocol ventricular viral surface virus virus infection website with COVID-19 [DOI] 10.1186/s13063-020-04527-4 PMC 바로가기 [Article Type] Study Protocol
COVID-19 Positive in Nasopharyngeal Swab but Negative in Peritoneal Fluid: Case Report of Perforated AppendicitisGeneral Surgery Published on 2020-07-272022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Appendicitis body fluids bowel Case report changed COVID-19 COVID-19 symptoms diagnosed hospital male N1 and N2 nasopharyngeal negative pathogenicity Patient patients with COVID-19 peritoneal fluid polymerase chain positive Proteins provide report RT-PCR RT-PCR test surgical tested Transcription Viral load virus was obtained [DOI] 10.7759/cureus.9412 PMC 바로가기 [Article Type] General Surgery
Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2, the etiologic agent of COVID-19 pandemic: an in silico approachBioinformatics Published on 2020-07-272022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory syndrome antigenic epitope applied approach average B-cell epitope binding bioinformatics candidate vaccine chimeric Chimeric Peptide Vaccine codon optimization coronavirus coronavirus disease Coverage COVID-19 Cytokines demonstrated docking E protein Ethnic groups expression IFN-γ IgG1 IgG2 IgM IL-2 Immune receptor immune response in silico Approach International mRNA Muti-epitope pandemic peptide predicted proliferation Proteins public health emergency SARS-CoV-2 secondary structure T-cell T-cell epitope T-helper cell TLR3 TLR4 Vaccine vaccine candidate Vaccine design WHO World Health Organization [DOI] 10.7717/peerj.9572 PMC 바로가기 [Article Type] Bioinformatics