Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ ResponsivenessArticle Published on 2020-09-292022-10-31 Journal: Cells [Category] COVID-19, [키워드] caused COVID-19 cytokine cytokine production Cytokine storm degranulation demonstrated dendritic cell dendritic cells disease driver feature forms functional Health highlight hyperinflammation IFN alpha immature Impaired innate immune Innate immunity Interaction interferon involved low expression maturation mechanisms monocyte Monocytes NETosis neutrophil Neutrophils pandemic disease PD-L1 phenotype profile reduce Research responses responsiveness SARS-CoV-2 SARS-CoV-2 virus severity of COVID-19 signature therapeutic targeting with COVID-19 [DOI] 10.3390/cells9102206 PMC 바로가기 [Article Type] Article
SARS-CoV-2 nsp1: Bioinformatics, Potential Structural and Functional Features, and Implications for Drug/Vaccine DesignsMicrobiology Published on 2020-09-292022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] analyzed Antiviral bioinformatics Bioinformatics analysis caused Characteristics conserved coronavirus coronavirus disease COVID-19 drug drug and vaccine development exhibit functional host mRNA inflammation response Innate immunity non-structural protein notable nsp1 other coronavirus pandemic Pathogenesis pathogenesis and development pathogenic factor Potential Prophylaxis Protein protein sequence reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 strain sequence sequence identity structure and function analysis tested translation Treatment strategies unique Vaccine viral infection Viral protein virulence Virus-host interaction [DOI] 10.3389/fmicb.2020.587317 PMC 바로가기 [Article Type] Microbiology
Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus ReplicationArticle Published on 2020-09-272023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] Antiviral endoplasmic reticulum stress influenza A virus Innate immunity thapsigargin unfolded protein response [DOI] 10.3390/v12101093 PMC 바로가기 [Article Type] Article
Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19Review Published on 2020-09-252022-10-30 Journal: Molecules [Category] COVID-19, [키워드] activities Anti-inflammatory antioxidant appear applied Compromised concomitance conditions Coronavirus disease 2019 COVID-19 Critical Diseases Effect effective energy metabolism ENhance Evolution example expected Fighting function Gender generate Glycolysis Health Host host cell Impact in viral increase individual infections Innate immunity MAVS melatonin metabolite Mitochondria mitochondrial Mitochondrial function Mortality outcome oxygen pandemic Pandemics pathogen pathogen’ Pathogens producing Protective reduce reduced required Respiratory disease seasonal flu severity Support susceptibility System targeting Tolerance viral infection viral infections viral infectious diseases virus infection [DOI] 10.3390/molecules25194410 PMC 바로가기 [Article Type] Review
The Impacts of Antivirals on the Coronavirus Genome Structure and Subsequent Pathogenicity, Virus Fitness and Antiviral DesignArticle Published on 2020-09-242022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] addition antibody Antiviral antiviral drug Antiviral treatment Bovine coronavirus Characteristics contribute coronavirus Coronaviruses disease Efficiency effort fitness genome structure host cell Impact Innate immunity Mutation pathogenicity question Remdesivir Research SARS-CoV-2 selected selection pressure Spike protein Structure test model the disease the spike protein Treatment Vaccine Vaccine development variant virus was used wild type [DOI] 10.3390/biomedicines8100376 PMC 바로가기 [Article Type] Article
Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVSArticle Published on 2020-09-182023-06-08 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, 신종인플루엔자, [키워드] Infection Innate immunity Molecular biology [DOI] 10.1038/s41392-020-00238-z PMC 바로가기 [Article Type] Article
Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to ImmunothrombosisImmunology Published on 2020-09-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, 신종인플루엔자, [키워드] alveolar injury alveolar lumen alveolar septa biopsy Cell Cell-mediated immunity cells Control COVID 19 COVID-19 diffusion edema Endothelial dysfunction expression Factor Future group Histopathology IL-4 immune responses immunothrombosis Innate immunity interleukin-4 (IL-4) interstitial lung mast cell mast cells (MC) MCs membrane pandemic patients perivascular plasma pneumocyte Pneumonia positive post-mortem lung Prevent recruited SARS-CoV-2 SARS-CoV-2 replication septa septal specimen Spread the cytokine storm Transcription upper airway upregulating [DOI] 10.3389/fimmu.2020.574862 PMC 바로가기 [Article Type] Immunology
Familial Mediterranean Fever and COVID-19: Friends or Foes?Immunology Published on 2020-09-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] addition analyzed bat C-reactive protein characterized clinical symptom Colchicine conserved COVID-19 COVID-19 patient COVID-19 patients Cytokine storm effective Familial Fever FMF disease Friend hallmark highly pathogenic Host Human humans IL-1 infections Inflammation inhibitor Innate immunity Laboratory Leukocytosis mammals Mutation off-label overlap Pain Patient Protein pyrin residue SARS-CoV-2 sequence severe disease the cytokine storm Treatment variant wildtype [DOI] 10.3389/fimmu.2020.574593 PMC 바로가기 [Article Type] Immunology
Weak Induction of Interferon Expression by Severe Acute Respiratory Syndrome Coronavirus 2 Supports Clinical Trials of Interferon-λ to Treat Early Coronavirus Disease 2019Article Published on 2020-09-152023-07-01 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, [키워드] Innate immunity MERS-CoV SARS-CoV Severe acute respiratory syndrome Virology [DOI] 10.1093/cid/ciaa453 PMC 바로가기
N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signalingArticle Published on 2020-09-112023-06-12 Journal: The Journal of Biological Chemistry [Category] B형 간염, [키워드] Cellular immune response Hep B) Hep C) hepatitis B virus (HBV hepatitis C virus (HCV immune evasion Innate immunity m6A modification RIG-I sensing viral immunology [DOI] 10.1074/jbc.RA120.014260 PMC 바로가기