Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation글루코사민은 Crz1 핵 전위를 촉진하여 Cryptococcus neoformans에서 페로몬 독립적인 이형 전이를 자극합니다Research Article Published on 2017-09-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Antifungal antifungal therapy attenuate calcineurin caused Cell cellular response clinically complex component Cryptococcal cells cryptococcal meningitis cryptococcosis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoplasm demonstrated disease downstream effector effectors elicited fertile fungal Genetic genetic screen glucosamine glycerol Host Host immune response host immune responses hosts identity immune responses immune-stimulatory independent independent of Interaction isolate limitations majority mammalian MAPK Meningitis morphogenesis Morphological morphological change Morphotype nuclear translocation nucleus Pathogenesis pathway pheromone phosphatase promote promoted PROTECT raise recent reference strain responsible serotype shown signaling pathway stimulate stimulated strain Stress stress response subsequent suppressed switching transcription factor translocation Trigger undergo Vaccine Vaccine development virulence virulent yeast [DOI] 10.1371/journal.pgen.1006982 PMC 바로가기 [Article Type] Research Article
Efficacy of phase 3 trial of RTS, S/AS01 malaria vaccine: The need for an alternative development planArticle Published on 2017-09-022024-08-27 Journal: Human vaccines & immunotherapeutics [Category] 말라리아, [키워드] Efficacy RTS S/AS01 malaria vaccine Vaccine development
A reverse genetics system for avian coronavirus infectious bronchitis virus based on targeted RNA recombinationResearch Published on 2017-06-122022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Accessory genes avian coronavirus cause Cell cell lines cells Characteristics chicken chimeric co-transfected coding Complete coronavirus ectodomain Embryonated eggs generate genetics Genome genomic growth IBV in vivo infect Infectious Bronchitis Virus isolates Major marker MHV Modification Molecular biology mouse hepatitis virus murine mutations parental poultry recombinant Recombination replaced respiratory pathogen Result Reverse genetics system RNA RNA recombination specific mutation spike gene spike glycoprotein strain Strains supplementary material synonymous Targeted RNA recombination Vaccine Vaccine development virulent virus was performed was used wild-type [DOI] 10.1186/s12985-017-0775-8 PMC 바로가기 [Article Type] Research
Novel Approach for Isolation and Identification of Porcine Epidemic Diarrhea Virus (PEDV) Strain NJ Using Porcine Intestinal Epithelial CellsArticle Published on 2017-01-212022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] approach Characteristics China clinical sample collected Culture Diagnosis diarrhea effective epidemic diarrhea epidemiological growth identification IEC intestinal epithelial cell isolation and identification molecular analysis Molecular biology Mutation novel outbreak PEDV porcine epidemic diarrhea virus (PEDV) NJ strain porcine intestinal epithelial cells Prevalence provide responsible strain survival TCID the S protein Vaccine Vaccine development Vero cells viral titer virus [DOI] 10.3390/v9010019 PMC 바로가기 [Article Type] Article
From discovery to licensure, the Adjuvant System storyReview Published on 2017-01-162024-09-02 Journal: Human vaccines & immunotherapeutics [Category] 대상포진, [키워드] Adaptive immune response adjuvant Adjuvant system Adjuvanted vaccine innate immune response Vaccine development [DOI] 10.1080/21645515.2016.1225635 PMC 바로가기 [Article Type] Review
Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in EgyptOriginal Article Published on 2017-01-042022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, MERS, [키워드] Active surveillance antibody Antibody titer Camel cause collected detection rate disease Egypt finding Host human infection Hypothesis implication Juvenile location management maternal antibody MERS-CoV Middle East Middle East respiratory syndrome Coronavirus nasal natural infection outbreak raised re-infected Re-infection rectal respiratory syndrome coronavirus RNA RT-PCR detection serum sample Support Surveillance sustained Urine Vaccine development virus zoonotic threat [DOI] 10.1038/emi.2016.130 PMC 바로가기 [Article Type] Original Article
Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report태반 말라리아 백신 및 면역 분석 조화의 임상 개발: 워크숍 보고서Article Published on 2016-09-172024-08-12 Journal: Malaria Journal [Category] 말라리아, [키워드] clinical trial harmonization immunoassays placental malaria Vaccine development [DOI] 10.1186/s12936-016-1527-8 PMC 바로가기
Immunogenicity and protective efficacy of recombinant fusion proteins containing spike protein of infectious bronchitis virus and hemagglutinin of H3N2 influenza virus in chickensArticle Published on 2016-08-032022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] bronchitis Cellular immune response contagious cytoplasmic tail demonstrated disease Efficacy Epitopes fused fusing fusion protein fusion proteins generate group H3N2 humoral IBV immunization immunized immunogenicity inactivated Infectious Bronchitis Virus Influenza virus injected inoculated M41 Protective protective immune response Protein recombinant fusion protein Recombinant S1 protein robust S1 protein significantly higher Spike protein transmembrane domain vaccination Vaccine Vaccine development viral respiratory Virus neutralization [DOI] 10.1016/j.virusres.2016.07.010 PMC 바로가기 [Article Type] Article
Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015Online Report Published on 2016-08-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Affect animal models Combination coronavirus Developing Dromedary Epidemiology Human international public health International Vaccine Institute MERS MERS coronavirus MERS-CoV Middle East Middle East respiratory syndrome Ministry of Health organizations Pathogenesis platform prevention public health researcher robust Saudi Arabia South Korea Spike protein syndrome therapeutic therapeutic antibodies Transmission Vaccine vaccine candidates Vaccine development Vaccines viruses workshop zoonosis [DOI] 10.3201/eid2208.160229 PMC 바로가기 [Article Type] Online Report
Status of vaccine research and development of vaccines for malariaArticle Published on 2016-06-032024-08-27 Journal: Vaccine [Category] 말라리아, [키워드] Elimination eradication malaria Vaccine development [DOI] 10.1016/j.vaccine.2015.12.074