Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells대유행 완화제 후보의 삼자 조합: 인간 세포에서 SARS-CoV-2 표적의 게놈 유도 추적으로 정의된 COVID-19 대유행의 표적 완화를 위한 약제의 비타민 D, 케르세틴 및 에스트라디올 매니페스트 특성Article Published on 2020-05-212022-09-10 Journal: Biomedicines [Category] 비임상, [키워드] 2019 coronavirus disease ACE2 activity Affect agent Alter analyses Analysis breath build candidate cell types cellular clinical trial clinical trials Combination condition contribute coronavirus coronavirus disease Coronavirus infection COVID-19 COVID-19 pandemic deficiency disease drug drugs drugs and medicinal substance repurposing Effect elements enrichment eriodictyol estradiol experiment expression expression profiling facilitate Follow-up function functions furin FURIN expression FURIN gene GATA5 gene expression profile Gene expression profiles gene expression signature Gene Set Enrichment Analyses gene silencing Genomics GSEA HIF1a high mortality HMGA2 HNF4A Human human body human cell human cells human gene human genes hypothetical identify Immediate Immune cell immune cells Immunosuppression Impact infect Infection Inference inhibitor inhibitors of SARS-CoV-2 INSIG1 interfere Intervention intrinsically Luteolin majority male Mitigation mitigation approaches molecular Mortality observation observational study observations Older overexpression pandemic Panel Patient persistence present property Protein Protein target protein targets Proteins quercetin Randomized randomized clinical trial Regulatory reported repressor required RUNX1 SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral selective severity SFTPC smoking Spread SUMMIT drug-docking screen target targets Testosterone the SARS-CoV-2 tissues tracing Transgenic mouse Treatment upstream utility Viral Viral protein Viral proteins virus Vitamin D vitamin D deficiency website [DOI] 10.3390/biomedicines8050129 PMC 바로가기 [Article Type] Article
Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19Review Published on 2020-05-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] activity acute respiratory syndrome affecting antiviral therapy clinical trial Consensus coronavirus coronavirus disease coronavirus epidemics Coronavirus infections COVID-19 COVID-19 therapy cysteine proteases drugs DUBs enzyme evaluated expressed function host cell host’s immune response immune response IMPROVE in vitro Infection inhibitor innate immune response intrinsic ISG15 majority Modification multifunctional opportunity outbreak pandemic Papain-like protease Pathogenesis pathway patient survival Pleiotropic effects PLP PLP inhibitors polypeptides Prevent protease Protein Proteins regulate Regulatory required responsible SARS SARS-CoV2 second Spread stability target proteins therapeutic strategy treat Treatment ubiquitin Viral pneumonia viral replication [DOI] 10.3390/ijms21103492 PMC 바로가기 [Article Type] Review
Prediction and analysis of key protein structures of 2019-nCoVShort Communication Published on 2020-05-122022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] 2019-nCoV Analysis Angiotensin-converting enzyme angiotensin-converting enzyme 2 back mutation binding ability database docking result Drug screening envelope protein Frame help homology homology alignment material membrane protein molecular Multiple sequence alignment Mutation nCoV nucleocapsid protein overlap performed predict predicted prediction protease Protein Proteins Result sequence Sequence analysis significant changes in Spike protein Structural analysis Structure Virtual screening [DOI] 10.2217/fvl-2020-0020 PMC 바로가기 [Article Type] Short Communication
The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica포스포릴레이 BarA/SirA는 Salmonella enterica에서 비동족 조절기 RcsB를 활성화합니다.Research Article Published on 2020-05-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated activating addition Alter Bacteria bacterium binding site Cell cell envelope cell wall changes in condition Control detect domain environmental stress expressed Gene Expression Genes growth help Infection life logarithmic growth Luria-Bertani medium modify organism Organisms outer membrane perturbations promote Protein Proteins RcsB regulator Regulatory respond RNA Salmonella Signal transduction specificity Spectrum Stress Transcription [DOI] 10.1371/journal.pgen.1008722 PMC 바로가기 [Article Type] Research Article
Master Regulator Analysis of the SARS-CoV-2/Human InteractomeArticle Published on 2020-04-012022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 protein affected apoptotic bioinformatics can be used coronavirus COVID-19 detect develop disease downregulation effort Epidemic gene network analysis host cell Infection interactome knowledge mechanisms mitochondrial molecular feature new virus outbreak performed Proteins reached receptor regulator respiratory tract SARS-CoV-2 therapy virus virus infection [DOI] 10.3390/jcm9040982 PMC 바로가기 [Article Type] Article
Quantitative Proteomic Analysis Reveals Antiviral and Anti-inflammatory Effects of Puerarin in Piglets Infected With Porcine Epidemic Diarrhea VirusImmunology Published on 2020-02-262022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] activities addition Administered African green monkey analyses Analysis Anti-inflammatory anti-inflammatory effect Anti-viral Antiviral assigned Blood caused Cell cell proliferation Chinese collected conducted Control control group control level Culture cytokine determine Effect effective epidemic diarrhea expression group growth IL-8 in vitro in vivo Infection infectious dose inhibited interferon-stimulated gene intestinal kidney mechanism multiplicity of infection Neonatal NF-κB activation PEDV pharmacological Piglets Porcine epidemic diarrhea virus Protein Proteins proteomic proteomics puerarin Randomly reductions in Replication restored serum-free DMEM sterile saline TCID three group tissue treated Trial two group upregulated Vero Vero Cell virus Volume were infected Western blot analysis [DOI] 10.3389/fimmu.2020.00169 PMC 바로가기 [Article Type] Immunology
Distinct Roles for Sialoside and Protein Receptors in Coronavirus InfectionResearch Article Published on 2020-02-112022-10-29 Journal: mBio [Category] COVID-19, [키워드] absence adaptive adhere betacoronaviruses binding Cell cell entry cell-cell fusion contribute coronavirus CoV CoV infection CoVs disease domain engage facilitated Focusing Host host cell receptor Human identify Infection infections intercellular membrane fusion MERS-CoV Middle East murine Mutation mutations Organisms pathogen promoted Protein Proteins raise receptor receptor-binding domains receptors recognize required respiratory syndrome coronavirus role severe respiratory disease sialic acid sialic acids Spike protein Spike proteins Spread Stage stages strain subsequent supported transmembrane transmembrane protein viral spike virus virus entry virus glycoproteins virus infection virus receptors virus spread virus-cell membrane fusion was increased zoonotic zoonotic transmission [DOI] 10.1128/mBio.02764-19 PMC 바로가기 [Article Type] Research Article
Characterization of novel monoclonal antibodies against MERS-coronavirus spike proteinArticle Published on 2020-01-132022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] amino acid substitution antibody binding affinity cause characterization chimeric coronavirus Critical develop domain East elicit epitope FIVE generate glycoprotein host cells identification immunization immunized lentivirus mAb mAbs MERS-CoV mice middle monoclonal antibody Mortality Mutation neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing effect not neutralize Protein Proteins pseudotyped pseudovirus Pulmonary infection RBD residue respiratory selected specific mutation spike Spike protein subunit Vaccine variant viral entry virus wild type [DOI] 10.1016/j.virusres.2020.197863 PMC 바로가기 [Article Type] Article
Analysis of preferred codon usage in the coronavirus N genes and their implications for genome evolution and vaccine designArticle Published on 2020-01-052022-11-01 Journal: Journal of virological methods [Category] Coronavirus, [키워드] Abstract Amino acid analysed Analysis codon Codon Bias codon usage Codons coronavirus correlation CoV CoV genome CoVs effective eight epidemic diarrhea Evolution function genetic analysis Genome genomic sequence Host host adaptation implication MERS Middle East Mutation N gene N genes neutrality nucleocapsid nucleocapsid protein nucleotide nucleotide change nucleotides Preferred nucleotides Protein Proteins ranged RNA similarity syndrome synonymous the N protein Transcription Vaccine design Variation viral genome virus [DOI] 10.1016/j.jviromet.2019.113806 PMC 바로가기 [Article Type] Article
Relation of Dietary Factors with Infection and Mortality Rates of COVID-19 across the WorldArticle Published on 2020-01-012023-07-05 Journal: The journal of nutrition, health & aging [Category] SARS, [키워드] acute respiratory infections dietary factors fruits macronutrients Proteins [DOI] 10.1007/s12603-020-1434-0 PMC 바로가기