Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brainResearch Published on 2012-09-212022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] addition Adenovirus administration against SARS-CoV airway Antibody Response Antigen Brain CD8 comparable coronavirus effective examined IgA IgA antibody immune response Immunity immunization inactivated viruses indicate induce infect Infection intramuscular intranasal lung mice mucosa mucosal mucosal route Neutralizing olfactory protective immunity protein antigens recombinant recombinant adenovirus Result Safe SARS-CoV SARS-CoV spike protein serum Severe acute respiratory syndrome shown Spike protein Sublingual Sublingual administration T cell T cell response tissues vector virus Virus-like particle [DOI] 10.1186/1743-422X-9-215 PMC 바로가기 [Article Type] Research
Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of MacrophagesArticle Published on 2012-05-242022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive antigen-presenting cell antiviral immunity antiviral state chemokines chronic infection coronavirus CoV CoVs Cytokines diminishe Express IFN-β IFNs Immunity induce infancy infect Infection investigation Ligand Macrophage macrophage cell line macrophages MHV MHV-A59 mouse hepatitis virus murine murine coronavirus not affect pattern recognition receptor Poly I:C positive-sense PRR PRRs RNA virus role selected single-stranded Stimulation suppresse susceptibility TLR TLR2 TLR3 TLR4 TLR7 TLRs triggering Type Type I IFN type I interferon viral infection viral infections virus production viruses [DOI] 10.3390/v4050901 PMC 바로가기 [Article Type] Article
The dominance of human coronavirus OC43 and NL63 infections in infantsArticle Published on 2011-12-192022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, MERS, [키워드] 229E addition childhood children determine disease elicit Epidemiology explain Frequency HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 healthy children HKU1 hospital Hospitalized Human coronavirus human coronavirus human coronavirus OC43 Immunity indication Infant infect infecting Infection infections less majority mild infection natural infection Newborn NL63 objective OC43 occur pathogenic positive PROTECT real time respiratory infection respiratory tract Result RT-PCR sequence Seroconversion seroconverted serology severe disease study group subsequent was determined [DOI] 10.1016/j.jcv.2011.11.011 PMC 바로가기 [Article Type] Article
Comparative Pathogenesis of Three Human and Zoonotic SARS-CoV Strains in Cynomolgus MacaquesResearch Article Published on 2011-04-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] acute respiratory syndrome against SARS-CoV change characterized Comparative compared Critical disease cynomolgus macaque Disease model Efficacy Epidemic exacerbated function Gene Heterologous histopathological Host host gene host response Human infect Infected Infection interferon signaling isolates macaque majority Mild pathogen pathogenicity pathway Pathways Prevent radiological regulated Replication SARS-CoV significant difference strain Strains subsequent therapeutic strategy Transmission Vaccine while zoonotic [DOI] 10.1371/journal.pone.0018558 PMC 바로가기 [Article Type] Research Article
Human coronavirus NL63: a clinically important virus?Special Report Published on 2011-02-022022-10-31 Journal: Future Microbiology [Category] Coronavirus, [키워드] cause childhood viral infections children Clinical features clinical symptom clinically coronavirus coronavirus detected diagnoses disease FIVE HCoV-229E HCoV-NL63 HCoV-OC43 Human Human coronavirus Immunocompromised incidence infect Infection infections knowledge Lower respiratory tract lower respiratory tract infection morbidity and mortality NL63 Occurrence Other respiratory viruses Prevalence respiratory respiratory tract infection respiratory viruses SARS-CoV shown upper respiratory tract upper respiratory tract infection [DOI] 10.2217/fmb.10.166 PMC 바로가기 [Article Type] Special Report
Prolonged depletion of circulating CD4 + T lymphocytes and acute monocytosis after pantropic canine coronavirus infection in dogsArticle Published on 2010-06-152022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] Alter B cell B cells B lymphocyte baseline level canine Canine coronavirus CD14 CD21 CD4 CD4+ T cell depletion CD8 CD8+ T cells circulating coronavirus Coronavirus infection days post-infection flow cytometry IgM immune infect Infected Infection lymphopenia monocytosis Peripheral blood monocyte Prolonged recovered completely remained returned serum IgG significantly T cell T lymphocyte [DOI] 10.1016/j.virusres.2010.06.006 PMC 바로가기 [Article Type] Article
Human coronaviruses are uncommon in patients with gastrointestinal illnessArticle Published on 2010-04-012022-11-01 Journal: Journal of Clinical Virology [Category] Coronavirus, MERS, [키워드] Adult children clinical clinical manifestation Clostridium difficile collected coronavirus coronavirus detected diarrhea disease emesis Frequency gastrointestinal disease HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HKU1 hospital Human illness implicated included individual infect infectious median neurologic NL63 NO objective occurred Patient pediatric positive positive patient positive sample presenting primer set recorded respiratory complaints respiratory finding respiratory tract Result RNA extraction RT-PCR Sample screened Stool submitted variety Viral gastroenteritis was performed [DOI] 10.1016/j.jcv.2010.03.007 PMC 바로가기 [Article Type] Article
Effects of Coronavirus Infections in ChildrenPerspective Published on 2010-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome caused Cell Central nervous system childhood circulating Community coronavirus CoV detect different early stage Effect emerging viruses Epidemiology facilitate HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 host range human coronaviruses human CoV infect Infection Isolation led to Manifestations Measures mutate pathogenicity Perspective Prevent recombine respiratory viruses RNA viruses SARS Spread strain Strains therapeutic These viruses virulent virus viruses [DOI] 10.3201/eid1602.090469 PMC 바로가기 [Article Type] Perspective
Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in ChinaArticles Published on 2009-09-272022-10-29 Journal: Philosophical Transactions of the Royal Society B: [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] Streptococcus suis addition Asia Avian Influenza Bacteria caused China coronavirus disease EHEC Escherichia coli expand fatality H5N1 highly pathogenic Host host range human pathogen implication infect Infection Influenza virus Isolation mammalian Molecular epidemiology occur outbreak pathogen pathogenicity PRRSV reproductive SARS-CoV serotype severe disease Shock Spread Streptococcus subsequent syndrome variant virus viruses zoonotic zoonotic pathogens zoonotic threat [DOI] 10.1098/rstb.2009.0093 PMC 바로가기 [Article Type] Articles
Temporal Variability and Social Heterogeneity in Disease Transmission: The Case of SARS in Hong KongResearch Article Published on 2009-08-212022-10-28 Journal: PLoS Computational Biology [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Affect applied Author average behavioural Better case change changes in Community Contact Course Critical different disease transmission effective Epidemic Epidemics epidemiological estimate event Evolution example functions General population healthcare healthcare worker Hong Kong hospital Hospitalized hospitals infect infectious influenza pandemic Markov chain mean measure observation outbreak parameter parameters Probability PROTECT provided public health measure recent reduced remained Reproduction number risk of infection SEIR shown subpopulation susceptible-exposed-infectious-removed sustained Temporal the SARS epidemic Transmission transmission rates was used were infected [DOI] 10.1371/journal.pcbi.1000471 PMC 바로가기 [Article Type] Research Article