sera – Page 77 – Communicable Diseases Research

Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection

Article

Published on 2019-05-252022-10-31
Journal: Emerging Microbes & Infections [Category] Coronavirus, MERS,

Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection

Research Article

Published on 2019-02-212022-11-01
Journal: JCI Insight [Category] Coronavirus, SARS,

[키워드] abrogated absence accumulated acute lung injury acute respiratory syndrome alveolar macrophage anti-spike antibody Antibody Response blockade cause Characteristics Chinese coronavirus CoV Cytokines Deceased demonstrated died driving Effects faster FcγR functional H7N9 hypercytokinemia IgG IL-8 immunoglobulins Infectious disease Inflammation Lung injury Lungs macaque macaques Macrophage response macrophages MCP1 mechanism MERS-CoV middle neutralizing antibody responses Patient patients proinflammatory promoted Pulmonology recruitment reduced response responsible SARS patient SARS-CoV SARS-CoV infection sera specimens syndrome Treatment viral clearance viruses
[DOI] 10.1172/jci.insight.123158 PMC 바로가기 [Article Type] Research Article

Middle East respiratory syndrome coronavirus infection in non-camelid domestic mammals

Article

Published on 2019-01-162022-10-31
Journal: Emerging Microbes & Infections [Category] Coronavirus, MERS,

Development of a Whole-Virus ELISA for Serological Evaluation of Domestic Livestock as Possible Hosts of Human Coronavirus NL63

Article

Published on 2019-01-092022-10-28
Journal: Viruses [Category] Coronavirus, MERS,

Combined use of ELISA and Western blot with recombinant N protein is a powerful tool for the immunodiagnosis of avian infectious bronchitis

Research

Published on 2018-12-122022-10-28
Journal: Virology Journal [Category] Coronavirus,

[키워드] amplified analysed antibody Antigen association bronchitis cDNA Cell Chromatography coding region coding sequence Combined combined use competent Concentration confidence interval controls demonstrated detect develop Diagnosis E. coli early diagnosis ELISA Escherichia coli evaluate examined expected expressed expression vector GE Healthcare GraphPad Prism GraphPad software greater IBV indirect ELISA Infectious Bronchitis Virus Invitrogen liquid molecular N protein nucleocapsid protein nucleoprotein PCR positive powerful tool Prevent primer Protein purification purified receiver-operating characteristics curves recombinant antigen required Result RT-PCR scored SDS-PAGE sensitivity sera serum dilution serum sample specificity subunit Test tested the disease the N protein USA was obtained were used Western blot analysis window yielding
[DOI] 10.1186/s12985-018-1096-2 PMC 바로가기 [Article Type] Research

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

Research Article

Published on 2018-10-092022-10-29
Journal: mBio [Category] Coronavirus,

[키워드] absence Activation acute respiratory syndrome Adaptive immune response animal models ARDS Bacterial cascade chemokine chemokines complement contributed controls coronavirus Coronavirus infection Critical cytokine Defense disease distress dysfunction effective exhibited fungal infections high-titer virus Host human infection identify immune Immune cell infiltration Infection Inflammatory cytokine inflammatory monocyte inhibiting intranasal investigated less lung Lung pathology mice mouse-adapted SARS-CoV neutrophil observation outbreak outcome outcomes Pathogenesis pathologic pathology pattern recognition receptor Proinflammatory response Protective reduced regulate relative Replication respiratory Respiratory disease respiratory viruses SARS-CoV SARS-CoV infection sera Severe case Signaling significantly stimulate subsequent syndrome systemic inflammation therapeutic These data Treatment Viral load weight loss
[DOI] 10.1128/mBio.01753-18 PMC 바로가기 [Article Type] Research Article

Chaperna-Mediated Assembly of Ferritin-Based Middle East Respiratory Syndrome-Coronavirus Nanoparticles

Immunology

Published on 2018-05-172022-11-01
Journal: Frontiers in Immunology [Category] Coronavirus, MERS,

[키워드] affected aggregation Antigen assembly Bacterial binding cellular receptor chaperone Concentration conformations contributed Control defined domain effective Escherichia coli expressed expression favor ferritin fused hDPP4 hosts immunization immunologically in silico in vitro Interaction kinetic lack linker Lysyl-tRNA synthetase MERS-CoV MERS-CoV RBD Microscopy Middle East Middle East respiratory syndrome Coronavirus molecular monomer monomeric Mutation nanoparticle pathway platform presenting proteolytic RBD Receptor-binding domain recombinant vaccine reducing respiratory RNA RNA-interacting domain of human LysRS robust scattering sera serological significantly increased stability Structure structures subsequent Vaccine viral infections Virus-like particle
[DOI] 10.3389/fimmu.2018.01093 PMC 바로가기 [Article Type] Immunology

Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia

Research Article

Published on 2018-04-262022-11-01
Journal: Journal of medical virology [Category] Coronavirus,

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4 -transgenic mice infected with MERS-CoV

Article

Published on 2018-04-242022-10-31
Journal: Emerging Microbes & Infections [Category] Coronavirus,

[키워드] accompanied activated Activation acute lung injury alleviate antibody treatment Apoptosis blockade C5a cause Cell cells chemokines complement Concentration contribute cytokine dysregulated elevated greater hDPP4 high mortality highly pathogenic Host immune response Inflammatory responses Intervention investigated less lung lung damage lung tissues manifested MERS-CoV MERS-CoV infection mice Middle East observation outcome Pathogenesis promote receptor reduced Respiratory failure respiratory syndrome coronavirus secretion sera spleen spleen tissue T cell tissue damage treated Treatment triggered viral infection viral replication
[DOI] 10.1038/s41426-018-0063-8 PMC 바로가기 [Article Type] Article

Asymptomatic Middle East Respiratory Syndrome coronavirus infection using a serologic survey in Korea

Original Article

Published on 2018-04-152022-10-31
Journal: Epidemiology and Health [Category] Coronavirus,

[키워드] 95% confidence interval affected angina Antibody test Arthritis Asymptomatic asymptomatic infection average collected conducted Contact coronavirus Coronavirus infection degenerative determine discharge ELISA Enzyme-linked immunespecific assay Epidemiology exhibited healthcare worker hospital Hospitalized hypertension IFA immunofluorescence assay include MERS MERS infection MERS patient Middle East Middle East respiratory syndrome Coronavirus no symptoms Nosocomial infections outbreak participant Patient plaque reduction neutralization positive PRNT Region respiratory selected sera tested Transmission underlying diseases was performed
[DOI] 10.4178/epih.e2018014 PMC 바로가기 [Article Type] Original Article