SARS-CoV-2 Viral RNA Shedding for More Than 87 Days in an Individual With an Impaired CD8+ T Cell ResponseCD8+ T 세포 반응이 손상된 개인에서 87일 이상 동안 SARS-CoV-2 바이러스 RNA 방출Observational Study Published on 2021-01-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] airway Antibody titer Antibody titers case subject CD4+ T cell CD8+ CD8+ T cell cellular immunity circulating Cohort COVID-19 Day detectable exhibited expected first positive Impaired in some individual individuals with COVID-19 Infection Neutralizing antibody response neutralizing antibody responses occur one individual plasma neutralization activity positive Prolonged Protein Re-infection response RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral RNA severe COVID-19 shedding subject subjects symptom onset T cell T cell responses T cells tested upper airway Viral Viral RNA Viral RNA shedding [DOI] 10.3389/fimmu.2020.618402 PMC 바로가기 [Article Type] Observational Study
Rapid GMP-Compliant Expansion of SARS-CoV-2–Specific T Cells From Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19COVID-19에 대한 동종 세포 치료제로 사용하기 위한 회복기 기증자의 SARS-CoV-2-특정 T 세포의 신속한 GMP 준수 확장Immunology Published on 2021-01-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법, [키워드] accumulation adoptive T cell immunotherapy Allogeneic Antigen antigens approach Blood Blood donations can be used caused CD4 CD8 cellular central memory characterized convalescent COVID-19 COVID-19 disease COVID-19 patients Culture Donor dysregulation effector T cell effector T cells expand expansion membrane memory T cell memory T cells nucleocapsid patients peptides phenotype Potential treatment Rapid reagent recognize SARS-CoV-2 spike SARS-CoV-2 virus selected T cell T cell response T cell responses T cells the SARS-CoV-2 virus therapeutic dose therapeutic doses therapy virus virus-specific T cell viruses [DOI] 10.3389/fimmu.2020.598402 PMC 바로가기 [Article Type] Immunology
B and T Cell Immunity in Tissues and Across the AgesReview Published on 2021-01-062024-09-02 Journal: Vaccines [Category] 대상포진, [키워드] B cells intestine mucosal immunity respiratory track T cells tissue-resident memory cells Vaccines [DOI] 10.3390/vaccines9010024 PMC 바로가기 [Article Type] Review
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection감염 후 최대 8개월 동안 평가된 SARS-CoV-2에 대한 면역학적 기억Research Article Published on 2021-01-062022-09-06 Journal: Science (New York, N.y.) [Category] Communicable Disease, Fulltext, MERS, 진단, [키워드] analyzed antibody B cells CD4 CD8 Cell circulating Course COVID-19 cases COVID-19 pandemic Critical declined diagnostics exhibited half-life IgG immune memory Infection memory memory B memory B cell memory B cells Post-infection Protein SARS-CoV-2 Spike protein Spike-specific memory B cells symptom onset T cell T cell memory T cells the Spike understanding Vaccines [DOI] 10.1126/science.abf4063 PMC 바로가기 [Article Type] Research Article
An anti-CD6 antibody for the treatment of COVID-19 patients with cytokine-release syndrome: report of three cases사이토카인 방출 증후군 코로나19 환자 치료를 위한 항CD6 항체: 3건 보고Case Reports Published on 2021-01-052022-08-31 Journal: Immunotherapy [Category] SARS, 바이오마커, 진단, [키워드] Abstract activated T cells Activation addition all the patients Anti-inflammatory therapy antibody anticoagulant therapy Antiviral CD6 CD6 molecule Concentration coronavirus 2 COVID-19 COVID-19 patient COVID-19 patients Critically ill cytokine-release syndrome Cytokines Expanded access expressed IFN-γ IL-6 immune cells immune system Inflammation Inflammatory Inflammatory cytokine itolizumab moderate moderate to severe monoclonal antibody morbidity and mortality outcome Patient patients pro-inflammatory cytokine pro-inflammatory cytokines progression Protein protocol psoriasis radiological improvement recognize reduce reduction respiratory Safe SARS-CoV-2 shown T cells the disease TNF-α treated Treatment [DOI] 10.2217/imt-2020-0235 PMC 바로가기 [Article Type] Case Reports
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection경도 높은 처리량 TCR 레퍼토리 프로파일링은 가벼운 COVID-19 감염 후 T 세포 기억 형성의 역학을 보여줍니다Short Report Published on 2021-01-052022-09-10 Journal: eLife [Category] 치료기술, [키워드] adaptive antibodies antiviral immune response caused CD4 CD8 changes in characteristic clonal expansion clone coronavirus COVID-19 COVID-19 infection COVID-19 patients cross-reactive cross-reactivity dataset Diversity donors fraction global pandemic Human immune memory immune response infected cell infected cells Infection killing longitudinal majority memory memory formation memory T memory T cell memory T cells Mild mild case motif Occurrence Participation Phenotypes RepSeq resulting reveal SARS-CoV-2 SARS-CoV-2 coronavirus Sequencing T cell T cells T-cell T-cell receptor T-cell Response TCR TCR sequence TCR sequences the SARS-CoV-2 virus-specific antibodies [DOI] 10.7554/eLife.63502 PMC 바로가기 [Article Type] Short Report
Immunological alternation in COVID-19 patients with cancer and its implications on mortalityObservational Study Published on 2021-01-042022-10-05 Journal: Oncoimmunology [Category] 임상, [키워드] Analysis B cells Cancer CD4 CD8 cells Chinese clinical Cohort cohorts conducted COVID-19 COVID-19 infection COVID-19 patient Cox regression cytokine dysregulated immune response elevated evaluate the effect greater had more High-sensitivity C-reactive protein IL-6 IL-8 immune Immune cell immune dysregulation immune response immune system immunological immunological characteristics implication increased mortality independent risk factor Inflammatory factor investigated Logistic regression malignancy Mortality mortality rate mortality risk NK cells Patient patients patients hospitalized poor prognosis procalcitonin Prognosis receptor Registered registry regressions remained retrospective cohort study risk of COVID-19 SARS-CoV-2 significantly significantly higher Stratification susceptible T cells those without cancer with COVID-19 [DOI] 10.1080/2162402X.2020.1854424 PMC 바로가기 [Article Type] Observational Study
The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients with Type 2 Diabetes Mellitus사이토카인 프로필과 면역 반응은 제2형 당뇨병을 가진 COVID-19 환자에서 증가합니다Comparative Study Published on 2021-01-022022-09-10 Journal: Journal of Diabetes Research [Category] 바이오마커, [키워드] adjusted average BMI CD4 CD8 COVID-19 COVID-19 patient COVID-19 patients Critical cytokine cytokine profile Cytokine storm diabetes Diabetes Mellitus elevated fasting glucose Glucose glucose metabolism Hospitalization IL-10 IL-2 IL-4 IL-6 immune response Increased Inflammation inflammatory state Inpatient Inpatients metabolism NDM Patient profile promoted response Serum level serum levels significant difference significantly higher significantly shorter T cell T cells TNF- α Type upregulated with COVID-19 [DOI] 10.1155/2021/9526701 PMC 바로가기 [Article Type] Comparative Study
Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19종단 임상 및 방사선 사진 평가에서 코로나19의 지속적인 폐 손상의 지표로 인터루킨-6이 밝혀졌습니다.Research Paper Published on 2021-01-012022-09-10 Journal: International Journal of Medical Sciences [Category] MERS, 바이오마커, [키워드] Admission Analysis analyzed association B cell B cells CD19 CD4 CD8 change Chest computed tomography Chest CT Clinical management collected Computed tomography coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patients cross-sectional analysis disease course elevated evaluate expression favor feature Features follow-up period IL-6 immunological increase in independent interleukin interleukin-6 Intervention laboratory-confirmed lesion lesions longitudinal Lung injury lymphocyte Lymphocytes Mild moderate Multivariate analysis neutrophil Neutrophils outcome Patient patients Peripheral blood Peripheral blood sample peripheral blood samples Previous studies previous study Prolonged pulmonary injury pulmonary lesion pulmonary lesions Radiographic rationale reveal scored semi-quantification sequential monitoring Severe patient severe patients significantly sustained T cells the disease [DOI] 10.7150/ijms.49728 PMC 바로가기 [Article Type] Research Paper
How could we forget immunometabolism in SARS-CoV2 infection or COVID-19?Review Published on 2021-01-012023-07-12 Journal: International reviews of immunology [Category] SARS, [키워드] B cells COVID-19 Immunity immunometabolism. SARS-CoV2 T cells [DOI] 10.1080/08830185.2020.1840567 [Article Type] Review