The impact of viremia on organ failure, biomarkers and mortality in a Swedish cohort of critically ill COVID-19 patients심각한 COVID-19 환자의 스웨덴 코호트에서 장기 부전, 바이오마커 및 사망률에 대한 바이러스혈증의 영향Observational Study Published on 2021-03-302022-09-10 Journal: Scientific Reports [Category] 바이오마커, 임상, 치료기술, 치료법, [키워드] Acute inflammation admitted to ICU age association Biomarker blood stream Cohort Consent contribute coronavirus disease Coronavirus disease 2019 Corticosteroid corticosteroid treatment COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients death defined had more hypertension ICU admission ICU patient ICU Patients independent Inflammation Innate immunity Mortality Organ failure Patient PCR plasma renal replacement therapy replacement therapy RNA copies RNA copy SARS-CoV-2 SARS-CoV-2 RNA copies SARS-CoV-2 RNA copy SARS-CoV2 Spread suggested Swedish Trial registration Ventilated viral infection Viremia virus with COVID-19 [DOI] 10.1038/s41598-021-86500-y PMC 바로가기 [Article Type] Observational Study
Nature and climate change effects on economic growth: an LSTM experiment on renewable energy resourcesResearch Article Published on 2021-03-292022-10-31 Journal: Environmental science and pollution research inter [Category] Coronavirus, MERS, SARS, [키워드] Brazil changes economic growth Effect experiment GDP impacts increase increase in LSTM Nature outbreak positive producing Promoting Renewable energy resources resource robust SARS-CoV2 sustainability variables [DOI] 10.1007/s11356-021-13337-3 PMC 바로가기 [Article Type] Research Article
Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airwayArticle Published on 2021-03-292022-10-04 Journal: Scientific Reports [Category] SARS, 신약개발, 임상, 치료제, [키워드] absence Activation airway approach Blood carried Cell clearance Comprehensive comprehensive analysis Computational biology and bioinformatics contribute coronavirus COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patients disease pathogenesis driven by drugs Gene Expression gene expression profile host response identify Infection Inflammation Inflammatory Inflammatory mediators Innate immune cells lung myeloid cell pathogenesis of COVID-19 patients Population potential therapeutic target SARS-CoV2 therapy transcriptional transcriptomic transcriptomic analysis viral infection virus [DOI] 10.1038/s41598-021-86002-x PMC 바로가기 [Article Type] Article
Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2Article Published on 2021-03-282023-07-02 Journal: Life sciences [Category] SARS, [키워드] COVID-19 cytokine Nanocurcumin Regulatory T cell SARS-CoV2 transcription factor [DOI] 10.1016/j.lfs.2021.119437 PMC 바로가기 [Article Type] Article
The Role of Mucosal Immunity and Recombinant Probiotics in SARS-CoV2 Vaccine DevelopmentReview Published on 2021-03-262023-06-15 Journal: Probiotics and antimicrobial proteins [Category] MERS, SARS, [키워드] bioengineering COVID-19 Lactic acid bacteria (LAB) Live mucosal vaccine Probiotics SARS-CoV2 [DOI] 10.1007/s12602-021-09773-9 PMC 바로가기 [Article Type] Review
Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatmentResearch Published on 2021-03-252022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] Affect Analysis animal animal model attenuate bioinformatic analysis cause conserved COVID-19 demonstrated disease Drosophila Effect effective Express expression Genes highly pathogenic Host human protein identify in vivo inhibit inhibiting mechanism muscle organism pathogenic pathogenicity phenotype Protein reduced Result resulting SARS-CoV-2 SARS-CoV-2 genes SARS-CoV-2 protein SARS-CoV2 selinexor supplementary material tested tissue tissues Toxicity transgenic Treatment various tissues viability viral gene Virus-host interaction XPO1 [DOI] 10.1186/s13578-021-00567-8 PMC 바로가기 [Article Type] Research
COVID-19 at War: The Joint Forces Operation in UkraineCommentary Published on 2021-03-252022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome aggression Alliance black caused Community confirmed case coronavirus coronavirus disease country COVID-19 COVID-19 pandemic described effective Europe fatality force global pandemic globe Health Health security health-care health-care system hospital identify Immunity impacted incidence incidence rate Infectious disease lab lack manifested mechanisms mitigate Mortality NATO North America North Atlantic Treaty Novel coronavirus operation outbreak pandemic peaks and trough positive post infection prevalence of COVID-19 preventative measures promote public health Region regions responses risk robust Russia SARS-CoV2 spreads state Structure Surveillance the disease therapeutic treat Treatment Ukraine Vaccine virus variant war in Ukraine WHO World Health Organization Wuhan, China zone [DOI] 10.1017/dmp.2021.88 PMC 바로가기 [Article Type] Commentary
Efficacy and safety of Levamisole treatment in clinical presentations of non-hospitalized patients with COVID-19: a double-blind, randomized, controlled trialRandomized Controlled Trial Published on 2021-03-242022-10-04 Journal: BMC Infectious Diseases [Category] 임상, [키워드] assigned clinical benefit clinical presentation clinical status Combination Controlled clinical trial cough Course COVID-19 COVID-19 patient distribution double-blind Dyspnea Efficacy enrolled evaluate Fever Follow-up Hydroxychloroquine immunomodulatory effect IMPROVE in both group interval Levamisole management men Mild Moderate COVID-19 MOST no significant difference oxygen Patient patients with COVID-19 Placebo Randomized randomized, controlled trial Randomly receive receiving Registered Result SARS-CoV2 shown significant difference significantly Standard of care study participant the disease the placebo group Treatment Trial two group was performed [DOI] 10.1186/s12879-021-05983-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Susceptibility and Severity of Viral Infections in Obesity: Lessons from Influenza to COVID-19. Does Leptin Play a Role?Review Published on 2021-03-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] adaptive immune system adipose approach association blunt Cell chronic complications Concentration concerning contribute Control COVID-19 determinant dysregulation Effect Effectiveness energy balance energy metabolism ER stress expressed Factors immune immune response immune system impair impairment Infection Infectious disease Inflammation inflammatory state Influenza influenza epidemic Interaction Leptin leptin resistance lesson mechanism metabolic microenvironment Multiple obesity outcome overcome pandemic Physical inactivity pleiotropic produced receptor reduced Regulatory Research responsible SARS-CoV2 severity Signaling Surveillance susceptibility tissue Vaccine vaccine-induced immune responses viral infection viral infections [DOI] 10.3390/ijms22063183 PMC 바로가기 [Article Type] Review
Human endogenous retrovirus-enveloped baculoviral DNA vaccines against MERS-CoV and SARS-CoV2Article Published on 2021-03-192022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome animal models baculovirus Cell-mediated immunity Complete Coronavirus-2 COVID19 DNA DNA vaccine DNA vaccines domain envelope gene expressing feasibility gene delivery Genome Human human cells humoral immunized induce MERS-CoV Middle East NTD pandemic spread provided RBD respiratory syndrome coronavirus retrovirus S1 subunit SARS-CoV-2 SARS-CoV2 SARS-CoV2 RBD Support Vaccine Vaccines viral infections [DOI] 10.1038/s41541-021-00303-w PMC 바로가기 [Article Type] Article