immune responses – Page 79 – Communicable Diseases Research

Transcriptional and Non-Transcriptional Activation, Posttranslational Modifications, and Antiviral Functions of Interferon Regulatory Factor 3 and Viral Antagonism by the SARS-Coronavirus

SARS-Coronavirus에 의한 Interferon Regulatory Factor 3과 Viral Antagonism의 전사 및 비전사 활성화, 번역 후 변형, 항바이러스 기능

Review

Published on 2021-03-292022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

Immunogenicity and Neutralizing Activity Comparison of SARS-CoV-2 Spike Full-Length and Subunit Domain Proteins in Young Adult and Old-Aged Mice

Article

Published on 2021-03-292022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] activity acute respiratory syndrome adjuvant aged mice antibodies approved B cell cellular immunity coronavirus domain ectodomain Effect effective Efficacy Emergency use full-length globe High dose humans IgG antibody IgG1 IgG2a immune responses immunogenic immunogenicity information inhibiting interferon-γ isotypes low dose mice Neutralizing Neutralizing activity pandemic disease RBD-hACE2 inhibition Receptor binding domain Result S1 and S2 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike-specific SARS-CoV-2 vaccine secreting spike subunit T cell the S1 subunit vaccination Vaccine vaccine antigen vaccine candidate vaccine dose
[DOI] 10.3390/vaccines9040316 PMC 바로가기 [Article Type] Article

An Overview of Current Knowledge of Deadly CoVs and Their Interface with Innate Immunity

Review

Published on 2021-03-262022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] acute respiratory distress Administered Anti-viral ARDS China common cold-like symptoms convalescent plasma coronavirus Coronaviruses CoV COVID-19 vaccine current death deaths develop disease effective Epidemiology evade Guangdong Host human coronavirus Hydroxychloroquine immune response immune responses Immunosuppressive treatment individual infecting Infection Innate Innate immunity interface MERS-CoV Middle East Mild modulate mortality rate MOST Pathogenesis Phylogeny pro-inflammatory produced Remdesivir Research respiratory respiratory tract RNA viruses SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Saudi Arabia severity spread to syndrome target therapeutic intervention therapy Transmission Treatment type I interferon viral life cycle viral structure viruses zoonotic
[DOI] 10.3390/v13040560 PMC 바로가기 [Article Type] Review

Inactivated rabies virus vectored SARS-CoV-2 vaccine prevents disease in a Syrian hamster model

비활성화된 광견병 바이러스 벡터 SARS-CoV-2 백신은 시리아 햄스터 모델에서 질병을 예방합니다

Research Article

Published on 2021-03-252022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, SARS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus animal model anticipated Asymptomatic asymptomatic infection asymptomatic infections best caused children coronavirus COVID-19 death develop disease evaluated events generate hamster hamsters highlight Human human disease illness immune response immune responses immunogenic inactivated indicated lung Lung disease Lung pathology Lungs MPLA nasal nasal turbinate nasal turbinates Neutralizing antibodies neutralizing antibody platform Pneumonia pregnant women Prevent prevented rabies Rabies virus Raby reduction in respiratory Respiratory failure robust Safe SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 vaccine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread Transmission trials Vaccine Vaccines vectored vaccine Viral viral replication virus weight loss worldwide pandemic
[DOI] 10.1371/journal.ppat.1009383 PMC 바로가기 [Article Type] Research Article

Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms

Cardiovascular Medicine

Published on 2021-03-252022-10-31
Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19,

[키워드] activated bleeding Blood cardiovascular system cascade cause cellular phenotypes circulating Coagulation coagulation cascade Coagulopathies complex composed connective tissue coronavirus COVID-19 pandemic Critical determinant disease Effect Endothelial cell fibrinolysis fibrinolytic fire Firestorm functions group immune cell responses immune cells immune response immune responses Infection Inflammation Inflammatory responses inhibitor Injury Interaction microthrombi modulate morbidity and mortality Pathogenesis pathway Platelet protease Protein Regulatory regulatory pathway representing resulting SARS-CoV-2 serine protease serpin surface receptor Thrombolysis thrombotic tissue injury Treatment Vascular virus
[DOI] 10.3389/fcvm.2021.648947 PMC 바로가기 [Article Type] Cardiovascular Medicine

SARS-CoV-2 Proteome-Wide Analysis Revealed Significant Epitope Signatures in COVID-19 Patients

SARS-CoV-2 Proteome-Wide Analysis, COVID-19 환자에서 중요한 에피토프 서명 밝혀

Clinical Trial

Published on 2021-03-232022-08-13
Journal: Frontiers in Immunology [Category] SARS, 임상, 진단,

[키워드] acute respiratory disease acute respiratory distress Antibody Response approach asymptomatic infection B cells causative agent China clinically coronavirus COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients death diagnostic disease epitope epitope identification exposure to high-density Host immune response humoral immune response Humoral response humoral responses IgG immune responses International Intervention leads Longevity marker Mild outcome peptide peptide microarray Predictive prognostic proteome public health emergency respiratory distress respiratory tract infection Revealed SARS-CoV-2 screened sera severe disease severe pneumonia signature Significant understanding Viral viral infection viral infections WHO
[DOI] 10.3389/fimmu.2021.629185 PMC 바로가기 [Article Type] Clinical Trial

One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection

MVA 벡터 백신을 1~2회 주사하면 SARS-CoV-2 상부 및 하부 호흡기 감염으로부터 hACE2 형질전환 마우스를 보호할 수 있습니다

423

Published on 2021-03-232022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-RBD antibodies antibody Cancer Cell chemokine clinical study Combination coronavirus coronavirus vaccine COVID-19 cytokine Deletion detection Diseases eight Express expressing form full-length S furin hACE2 hACE2 receptor human clinical trials IFNγ immune response immune responses Immunity immunized immunogenic in vitro indicated infected cells Infection infection with SARS-CoV-2 Infectious disease Infectious diseases inhibited injection Intramuscular injection intranasal lethal infection Lower respiratory tract lung Lungs mice modifications modified vaccinia virus modified vaccinia virus Ankara morbidity mRNAs Mutation nasal turbinate nasal turbinates neutralized neutralizing antibody nucleic acids occurred other infectious diseases pandemic passive transfer peptide Prevent prevented proline proline substitutions Protein Proteins provided pseudovirus purified RBD question RBD Receptor binding domain recombinant reduced Replication required respiratory S protein Safe SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 S protein severe acute respiratory syndrome Coronavirus severe disease shown signal peptide Significance single vaccination smallpox vaccine Spread stimulate subgenomic mRNA subgenomic mRNAs subgenomic viral mRNA subgenomic viral mRNAs T cells the S protein the SARS-CoV-2 the signal peptide transfer transgenic mice Transgenic mouse transgenic mouse model transmembrane domain transmembrane domains upper and lower respiratory tracts vaccination Vaccine vaccinia virus Ankara vector vectors Viral virus Virus vector weight loss
[DOI] 10.1073/pnas.2026785118 PMC 바로가기 [Article Type] 423

Insights into coronavirus immunity taught by the murine coronavirus

Article

Published on 2021-03-222023-07-01
Journal: European Journal of Immunology [Category] SARS,

[키워드] animal models Host/pathogen interaction immune responses mouse hepatitis virus SARS‐CoV‐2
[DOI] 10.1002/eji.202048984 PMC 바로가기

Dietary and Protective Factors to Halt or Mitigate Progression of Autoimmunity, COVID-19 and Its Associated Metabolic Diseases

Review

Published on 2021-03-192022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

[키워드] abnormal immune response activate Anti-inflammatory antioxidant Antiviral approach Autoimmune disease Combination complications of COVID-19 COVID-19 Critical dietary Disease progression evidence of Factor fatty acids feasible form H1N1 virus hypercoagulability immune responses impairment increasingly Infection inhibit lactoferrin melatonin metabolic metabolic disease Metabolic diseases metabolic effect mitigate natural supplements omega-3 outbreak pandemic Pathways patients with SARS-CoV-2 Polyunsaturated protocol quercetin risk factor SARS-COV-2 infection severe COVID-19 stimulated subject suggested T1D the cytokine storm therapeutic therapy Treatment Type vaccination Vitamin C
[DOI] 10.3390/ijms22063134 PMC 바로가기 [Article Type] Review

Immunity to SARS-CoV-2: Lessons Learned

SARS-CoV-2에 대한 면역: 교훈

Review

Published on 2021-03-192022-09-11
Journal: Frontiers in Immunology [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen approaches breadth Cellular immune response children clinical trials coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses Coverage COVID-19 domain duration of protection Efficacy elicited Emergency use authorization etiology immune correlate immune correlates immune response immune responses Immunity infected individual Infection knowledge lesson molecular pandemic Phase 3 populations Preexisting immunity pregnant women Receptor-binding domain reported Research respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants serology severe acute respiratory syndrome Coronavirus Special populations Spike protein systems serology the spike protein trajectory vaccination Vaccine Vaccine development virus
[DOI] 10.3389/fimmu.2021.654165 PMC 바로가기 [Article Type] Review