The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus InfectionResearch Article Published on 2016-12-132022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] abrogate acute respiratory syndrome ADP-ribose ADP-ribosylation antiviral property Cell culture changes in conserved coronavirus Coronavirus infection CoVs disease domain elicited enzyme epithelial cell line help highly pathogenic human CoV IFN Impact in viral in vitro Inclusion Infection Innate innate immune response Innate immunity interferon interferon-stimulated gene ISG lethal disease macrodomain mechanism mice Modification mutant virus Mutation mutations nonstructural protein 3 Nsp3 Pathogenesis positive-sense Proinflammatory cytokine promote PROTECT Protein protein targets Proteins reduced reducing reduction regulate Regulation Replication respiratory response RNA viruses SARS-CoV SARS-CoV infection strain suppressed target therapy understanding Viral load virulence virus virus attenuation [DOI] 10.1128/mBio.01721-16 PMC 바로가기 [Article Type] Research Article
Allelic Variation in CXCL16 Determines CD3 + T Lymphocyte Susceptibility to Equine Arteritis Virus Infection and Establishment of Long-Term Carrier State in the StallionCXCL16의 대립형질 변이는 말 동맥염 바이러스 감염에 대한 CD3 + T 림프구 감수성과 종마의 장기 보균자 상태 확립을 결정합니다Research Article Published on 2016-12-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acute infection allele allelic variant Amino acid amino acid change arteritis association carrier carrier state carriers causative agent CD3 cellular receptor cellular receptors chromosome 11 correlated correlated strongly CXCL16 demonstrated determine disease dominant equine ExoN exon 1 exposure to Genetic Genome Genome wide association study GWAS higher risk Ile Illumina implicated in vitro In vitro infection infect Infection inheritance Laboratory lack less life lymphocyte Lymphocytes maintenance male MOST Mutation natural infection Non-synonymous nucleotide nucleotide substitution nucleotide substitutions orthologue outcome persistence phenotype Phenotypes phenotypic phenotypic trait Previous studies previous study Probability proportion Protein protein isoform Proteins receptor reported reproductive required respiratory responsible risk scavenger receptor Semen shown significantly higher significantly lower Stallion susceptibility susceptible T lymphocyte T lymphocytes Two alleles Viral viral persistence virus virus carriers were used [DOI] 10.1371/journal.pgen.1006467 PMC 바로가기 [Article Type] Research Article
Distinct Prion Domain Sequences Ensure Efficient Amyloid Propagation by Promoting Chaperone Binding or Processing In Vivo고유한 프리온 도메인 서열은 생체 내 샤페론 결합 또는 처리를 촉진하여 효율적인 아밀로이드 증식을 보장합니다Research Article Published on 2016-11-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting aggregate Alter Amino acid amyloid assembly binding change chaperone chaperones complementary composed conformation conformational conformational flexibility contribute creating efficient element elements Ensure functional in vitro in vivo inheritance Interaction maintain mechanism molecular observation occur open persistence physical physical properties predict prion processing promote Promoting Propagation Protein Protein misfolding Proteins proximal PSI question Regulation required resulting sequence Spectrum stability Transmission yeast [DOI] 10.1371/journal.pgen.1006417 PMC 바로가기 [Article Type] Research Article
Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome네오센트로미어는 칸디다 알비칸스 염색체를 따라 여러 유전자좌에 염색체 분리 정확도 및 중심체 클러스터링을 제공합니다Research Article Published on 2016-09-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy adaptation addition approach assembly benefit Cancer cancer cell Cancer cells cancers Candida Candida albican Candida albicans caused Cell cell division centromere change Chemotherapy chromosome chromosome 5 chromosome segregation chromosomes Cluster Clustering complexes consequence Contact copy number de novo defined disease DNA DNA sequence drug resistance error rate exhibit function functional functions Gene Expression Genes Genome greater independent independent of instance kinetochore leads Like loci maintain mechanisms Multiple nuclear nucleus observation occur organism protein complex Proteins provide recent reduced Region reorganization required segregation speciation stability Support the cells three-dimensional structure Transcription yeast [DOI] 10.1371/journal.pgen.1006317 PMC 바로가기 [Article Type] Research Article
Human Management of a Wild Plant Modulates the Evolutionary Dynamics of a Gene Determining Recessive Resistance to Virus Infection야생 식물의 인간 관리는 바이러스 감염에 대한 열성 내성을 결정하는 유전자의 진화 역학을 조절합니다Research Article Published on 2016-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allele alleles analysed Analysis assays Capsicum coding sequence cultivation Defense Determining Diseases Diversity Dynamics Effect electrostatic Evidence evidence of Evolution full-length functional gene encode Genetic variation genetics host-pathogen interaction host-pathogen interactions Human impairing Infection infection assay infection assays initiation factor Interaction involved loci management mapping Mutation Neutral no evidence of pathogen phenotypic Phylogeny physical plant plant virus plants Population populations Positive selection Potyvirus Proteins R genes recessive recognize resistance resistance gene resistance mutations Result resulting severity supported susceptibility translation initiation triggering Variation variety Viral viruses [DOI] 10.1371/journal.pgen.1006214 PMC 바로가기 [Article Type] Research Article
Trigger factor assisted soluble expression of recombinant spike protein of porcine epidemic diarrhea virus in Escherichia coliResearch Article Published on 2016-05-042022-10-27 Journal: BMC Biotechnology [Category] Coronavirus, [키워드] antigens chaperone Chaperone co-expression system cloned co-expression condition contagious develop elicited ELISA epidemic diarrhea Escherichia coli expressed expression expression vectors immune immunization immunogenic Inclusion inclusion bodies mAb mice neutralizing antibody pathogen PEDV produced Protein protein antigen Proteins purified reactivity Recombinant protein recombinant proteins Recombinant spike protein Result S protein sera serum IgG Serum neutralizing antibody spike glycoprotein Strains subunit Subunit vaccine supplementary material tested Trigger Trigger factor Vaccine variety virus western blot [DOI] 10.1186/s12896-016-0268-7 PMC 바로가기 [Article Type] Research Article
The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and HistonesCaenorhabditis elegans 단백질 FIC-1은 Heat-Shock 70 계열 단백질, 번역 연장 인자 및 히스톤을 공유적으로 수정하는 AMPylase입니다Research Article Published on 2016-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] approach ATP bacterial pathogen biochemical Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans connection consequence conserved core histone domain elegan elegans elongation elongation factors Endoplasmic reticulum Factor Factors family family members functional Heat shock heat shock protein heat-shock protein histone identify in vitro in vivo innate immune response Innate immunity modify novel nuclear ortholog P . aeruginosa pathogen phenotype post-translational modification Previous studies previous study Protein Proteins Pseudomonas aeruginosa sequence identity substrate susceptibility target protein target proteins three-dimensional structure translation unfolded protein response UPR [DOI] 10.1371/journal.pgen.1006023 PMC 바로가기 [Article Type] Research Article
Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila트랜스포존 조절 장애는 초파리에서 생식선 줄기 세포 분화를 제어하기 위해 dWnt4 신호를 조절합니다Research Article Published on 2016-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acts aging Cancer cancers Cell cell fate cell population cell types chromatin Control degenerative degenerative diseases differentiation differentiation defects disease downregulated Drosophila element elements encapsulation expression facilitate female Genetic Genome germline GSC independent insight lead Ligand Loss maintain mammary marker mechanism methyltransferase modulate multicellular multicellular organism mutants oogenesis organism Perspective progression promote Proteins regulate regulated repress required Signaling somatic cells STEM stem cell stem cells sustained therapeutic tissue tissues transposable elements transposon transposons upregulation virus while Wnt Wnt4 [DOI] 10.1371/journal.pgen.1005918 PMC 바로가기 [Article Type] Research Article
Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis PneumoniaHIV-1 질병 진행 및 기포자폐렴에서 APOBEC3F 유전자 변이의 역할Research Article Published on 2016-03-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI acquisition Affect AIDS allele Americans antiviral activity APOBEC3 cytidine deaminase APOBEC3F APOBEC3G association cohorts collaboration cytidine cytidine deaminases Degradation degrade demonstrated disease Disease progression ENCODE epidemiological European Evidence Factor Frequency gene family Genetic genetic association Genetic variant genetic variants Genomics Haplotype hazard HIV HIV disease HIV-1 host susceptibility Human in vitro in vitro experiments in vivo intrinsic modify modulate Pathogenesis pathway performed Pneumonia progression Protein Proteins provide reduced relative resistance factors resolved role significantly lower SNP validation study variant Viral viral infectivity Viral load [DOI] 10.1371/journal.pgen.1005921 PMC 바로가기 [Article Type] Research Article
Arterivirus nsp12 versus the coronavirus nsp16 2′- O -methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteinsStandard Published on 2015-09-012022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, [키워드] acting analysed Analysis aromatic residue arteritis arterivirus assumed biochemical assay Bioinformatics analysis C-terminal cleavage conserved coronavirus detect domain ENCODE enzyme equine family Coronaviridae genetics implicated knowledge Methylation mRNA mRNAs Nidovirale nidovirus Nsp12 ORF1b phenotype polyprotein pp1ab Protein Proteins Replication similarity statistically significant Substitution subunit transcripts tyrosine virus yielding β-strands [DOI] 10.1099/vir.0.000209 PMC 바로가기 [Article Type] Standard