utility – Page 79 – Communicable Diseases Research

High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms

고위험군 분리가 두개내 동맥류에 걸리기 쉬운 저주파 변이를 나타냅니다

Research Article

Published on 2014-01-302022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Aneurysm arteries Artery association Author balloon bleeding bottleneck events Brain Case-control cause compared complex complex diseases contribute Control controls develop different disease effect size effect sizes European population events explain explained Families Finn Finnish Finns FIVE fraction frequencies Frequency genetic background Genetic variant Genetic variation genotype imputation GWAS hemorrhage heritability identify incidence Inconclusive Intracranial intracranial aneurysms isolate isolates knowledge lead life-threatening loci locus low frequency MAF matched controls Netherland Netherlands Patient Population populations rare variant Rare variants related replicated rupture saccular stroke Study design Subarachnoid subarachnoid hemorrhage susceptibility tested utility variant variants
[DOI] 10.1371/journal.pgen.1004134 PMC 바로가기 [Article Type] Research Article

Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes

기능적 변이에 대한 유전적 편협성과 개인 게놈의 해석

Research Article

Published on 2013-08-222022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Author caused Characteristics defined develop developmental disorder developmental disorders different disease disease causing disorder disorder classe disorder classes effort ESP example excess Exome Exome Sequencing Project expected facilitate found functional functional genetic variation functional variant functional variation Gene genetic disease Genetic variation Genome genome-wide scoring healthy individuals human disease human disease network human gene human genes human population Immunological disorders in healthy individual intolerance intolerance score intolerance scoring less Mendelian disease Mendelian diseases Mutation mutations Neutral NHLBI nucleotide occur opposite pathogenic mutations quantitative assessment responsible sequence significantly more Single nucleotide variant standing genetic variation utility variants Variation
[DOI] 10.1371/journal.pgen.1003709 PMC 바로가기 [Article Type] Research Article

A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses

Research Article

Published on 2013-07-252022-10-28
Journal: PLoS ONE
[Category] Coronavirus,

Approaching the Functional Annotation of Fungal Virulence Factors Using Cross-Species Genetic Interaction Profiling

종간 유전적 상호작용 프로파일링을 사용하여 진균 독성 인자의 기능적 주석 접근

Research Article

Published on 2012-12-272022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] accurate AIDS analyzed annotation approach Author C. neoforman C. neoformans C. neoformans gene C. neoformans genes calculation Cancer Cell cell surface Chemotherapy compared conserved correlated correlation correlations Cryptococcus neoforman Cryptococcus neoformans death deletion mutant deletion mutants demonstrated develop disease enhancement expressed expression Factor found function functional functional annotation fungal fungal pathogens fungi Gene gene deletion gene function Genetic genetic interaction genetic interactions Golgi Golgi apparatus growth HIV/AIDS HIV/AIDS patients human pathogen identify immunostimulatory individuals Infection inhibiting Interaction interactions lack mannose molecular mutant Organ transplant organism Organisms ortholog pathogen pathogenicity pathogenicity protein Pathogens patients phagocytosis predict predicted profile profiles Profiling promote quantification Quantitative recipient required S. cerevisiae Saccharomyces cerevisiae sequence supported suppression susceptible tested the cell understanding utility validation virulence virulence gene yeast
[DOI] 10.1371/journal.pgen.1003168 PMC 바로가기 [Article Type] Research Article

Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function

SNP 및 SNP-by-Smoking 상호 작용의 게놈 전체 공동 메타 분석은 폐 기능에 대한 새로운 유전자좌를 식별합니다

Research Article

Published on 2012-12-202022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Affect analysis applied association Author Autoimmune cigarette smoking compared complex conducted demonstrated differential expression DNER DQB1 Effect Effects European evaluated Evidence evidence of expiratory expressed FEV forced expiratory volume forced vital capacity found function Gene gene region Genetic genetic loci genetic risk factor Genome-wide association studies Genome-wide association study highlight HLA region HLA-DQA2 HLA-DQB1 Human airway epithelium human lung tissue identify implicated Interaction involved joint KCNJ2 loci lung Lung disease measure meta-analysis Meta-analysis meta-analysis model novel nucleotide Phenotypes polymorphism progression pulmonary Pulmonary function Region regions related shown single nucleotide Single nucleotide polymorphism smoker Smokers smoking SNP SNPs SOX9 study participant trait utility vital capacity Volume
[DOI] 10.1371/journal.pgen.1003098 PMC 바로가기 [Article Type] Research Article

The Adjuvanticity of an O. volvulus -Derived r Ov -ASP-1 Protein in Mice Using Sequential Vaccinations and in Non-Human Primates

Research Article

Published on 2012-05-172022-10-28
Journal: PLoS ONE
[Category] Coronavirus,

[키워드] Activation adjuvant adjuvanticity administration anti-RBD antibody Antibody Response antigens bystander Course DC different Effectiveness Efficacy element first vaccination functional host response IFN-γ IgG2a IL-2 IL-6 immunized induce Influenza virus maturation mice naïve NHPs non-human primate not affect Onchocerca volvulus primate promote promoted Protective protective immune response Protein provided RBD reported retained SARS-CoV spike protein sera subsequent Th1 Th1 cytokines Th2 response the receptor-binding domain titre TNF-α upregulated utility vaccination Vaccine vaccine antigen virus strains was used
[DOI] 10.1371/journal.pone.0037019 PMC 바로가기 [Article Type] Research Article

Plaque assay for human coronavirus NL63 using human colon carcinoma cells

Methodology

Published on 2008-11-122022-10-28
Journal: Virology Journal
[Category] Coronavirus,