Evaluation of the Panbio COVID-19 Antigen Rapid Diagnostic Test in Subjects Infected with Omicron Using Different Specimens다양한 표본을 사용하여 오미크론에 감염된 피험자에서 Panbio COVID-19 항원 신속 진단 검사 평가Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ag-RDT amplification Antigen B.1.1.529 Concordance coronavirus COVID-19 COVID-19 diagnosis COVID19 demonstrated Diagnosis diagnostic test Infection mutated nasal nasal swab nasal swabs nasopharyngeal sample Nasopharyngeal samples omicron Omicron variant oral oral swab oral swabs PanBio pandemic Patient PCR positive sample primary site Quantitative quantitative reverse transcription-PCR raised Rapid Rapid antigen tests Rapid diagnostic test Rapid test Replication reverse transcription-PCR RT-qPCR sample collection SARS-CoV-2 SARS-CoV-2 positivity sensitivity severe acute respiratory syndrome Coronavirus specimen symptomatic individuals Test tested Transmission variant VoC was performed was used [DOI] 10.1128/spectrum.01250-22 PMC 바로가기 [Article Type] Article
Protective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2SARS-CoV-2에 대한 보호 프로토타입-베타 및 델타-오미크론 키메라 RBD-이량체 백신Article Published on 2022-06-232022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단, [키워드] approach Beta breakthrough infections chimeric circulating COVID19 COVID19 vaccine Delta delta variant develop dimeric domain elicited forms immunogen structure immunogens Infection macaques mice multivalent vaccine neutralization omicron Omicron variant pandemic prevalent protein subunit vaccine prototype RBD RBD-dimer Receptor-binding domain SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera Subunit vaccine supported Vaccine vaccine protection variant variant of concern variants VoC ZF2001 [DOI] 10.1016/j.cell.2022.04.029 PMC 바로가기 [Article Type] Article
Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment증례 보고: SARS-CoV-2 감염이 오래 지속된 APDS 환자 1명에서 단일클론항체로 성공적인 치료Case Reports Published on 2022-06-212022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] activated activated PI3K delta syndrome (APDS) administration affected APDS clearance COVID19 described Efficacy first positive genotyping IEI Infection LINE long-lasting long-lasting infection monoclonal monoclonal antibodies monoclonal antibody multiple therapeutic agent multiple therapeutic agents neutralizing monoclonal antibodies other treatments Patient pauci-symptomatic PI3K Prolonged reducing Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Swab syndrome tested the SARS-CoV-2 virus therapeutic agents Tolerability treated Viral viral shedding virus wild type [DOI] 10.3389/fimmu.2022.891274 PMC 바로가기 [Article Type] Case Reports
Small-molecule metabolome identifies potential therapeutic targets against COVID-19소분자 대사체는 COVID-19에 대한 잠재적인 치료 표적을 식별합니다Article Published on 2022-06-152022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] Accuracy biochemical change characterized composed Concentration controls COVID-19 COVID-19 infected individual COVID19 COVID19 patient disease severity evaluate host cell identify Infection metabolome metabolomic signature microbes nasal nasal mucosa nasopharyngeal Patient potential therapeutic target potential therapeutic targets primer produced qRT-PCR R 2 respiratory respiratory syncytial virus RSV SARS-CoV-2 significantly significantly increased small molecule tested transmitted unique viral infection Viral load virus [DOI] 10.1038/s41598-022-14050-y PMC 바로가기 [Article Type] Article
Risk Factors for Weak Antibody Response of SARS-CoV-2 Vaccine in Adult Solid Organ Transplant Recipients: A Systemic Review and Meta-AnalysisMeta-Analysis Published on 2022-06-142023-07-09 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Antibody Response COVID19 Meta-analysis organ transplantation Risk factors SARS-CoV-2 vaccine [DOI] 10.3389/fimmu.2022.888385 PMC 바로가기 [Article Type] Meta-Analysis
Early dexamethasone use as a protective measure in non-mechanically ventilated critically ill patients with COVID-19: a multicenter, cohort study Research Published on 2022-06-132022-10-05 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] 1:1 24 hour benefit cohort study consequence COVID-19 COVID19 Critically ill patient debatable Dexamethasone higher odd hospital ICU admission ICUs in-hospital mortality initiated intensive care unit LOS mechanical ventilation Mortality multicenter multicenter cohort study outcome Patient patients with COVID-19 Prevent primary endpoint Propensity score Protective required Respiratory failure SOFA score statistically significant the timing Tocilizumab two group Ventilated ventilated patients was used with COVID-19 [DOI] 10.1038/s41598-022-13239-5 [Article Type] Research
Early outcomes in adults hospitalized with severe SARS-CoV-2 infection receiving tocilizumab중증 SARS-CoV-2 감염으로 입원하여 토실리주맙을 투여받은 성인의 조기 결과Article Published on 2022-06-102022-09-12 Journal: Medicina clínica [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI Administered administration Admission adults hospitalized age ARDS Barcelona baseline Charlson index cohort study consecutive patient COVID-19 COVID19 Critical disease dose Endpoint English hazard hazard ratio Hebron IL6 Immonomodulation immune system Infection Inmunomodulación intensive care IQR Lung injury male media Mortality Neumonía viral New coronavirus outcome oxygen supplementation Patient patients patients with COVID-19 Pneumonia Preliminary data Prevent primary endpoint receiving respiratory SARS-CoV-2 SARS-COV-2 infection secondary severe SARS-CoV-2 Spain Spanish symptom onset the median Tocilizumab tocilizumab administration treated treatment with tocilizumab university Viral pneumonia [DOI] 10.1016/j.medcli.2021.06.012 PMC 바로가기 [Article Type] Article
Serological study of CoronaVac vaccine and booster doses in Chile: immunogenicity and persistence of anti-SARS-CoV-2 spike antibodies칠레의 코로나백 백신 및 부스터 용량에 대한 혈청학적 연구: 항-SARS-CoV-2 스파이크 항체의 면역원성과 지속성Article Published on 2022-06-092022-09-12 Journal: BMC Medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activating affected age anti-SARS-CoV-2 antibodies antibody antibody production Antibody Response Antibody titer BNT162b2 BNT162b2 vaccine booster booster dose ChAdOx1 ChAdOx1 vaccines collected Combination CoronaVac country Course COVID-19 COVID19 Decline dose elicited ELISA assay generate Heterologous homologous homologous or heterologous humoral Humoral response immunological Immunological memory implementation individual induce interquartile range IQR less magnitude median median age outbreak persistence Prevent remained response SARS-CoV-2 Spike protein the antibody response the disease the SARS-CoV-2 vaccinate vaccination vaccination schedule Vaccine [DOI] 10.1186/s12916-022-02406-0 PMC 바로가기 [Article Type] Article
Probiotics for Reduction of Examination Stress in Students (PRESS) study: A randomized, double-blind, placebo-controlled trial of the probiotic Lacticaseibacillus rhamnosus HN001Randomized Controlled Trial Published on 2022-06-082022-10-05 Journal: PLoS ONE [Category] 임상, [키워드] Anxiety baseline benefit Compound COVID19 determine double-blind Evidence examination Factor groups highlight human population IMPROVE Intervention measure no significant difference outcomes pandemic Placebo placebo-controlled study placebo-controlled trial post-intervention Probiotics Psychological psychological health Psychological outcome Randomized reduced Stress student supplemented group trajectory Trial [DOI] 10.1371/journal.pone.0267778 PMC 바로가기 [Article Type] Randomized Controlled Trial
Baricitinib in hospitalised patients with COVID-19: A meta-analysis of randomised controlled trialsResearch article Published on 2022-06-032022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 28-day mortality 95% CI Analysis Anti-inflammatory Anti-viral Baricitinib COVID COVID19 database death Dexamethasone discharge disease duration of hospitalisation ECMO Efficacy finding funding hospitalised patient improved mortality IMV inhibitor Invasive mechanical ventilation Jak Janus kinase Janus kinase inhibitors Meta-analysis outcome patients patients with COVID-19 performed positive pressure ventilation progression PROSPERO database random-effects model randomised controlled trial RCT reduce mortality reduced Registered Respiratory failure searched severe disease shown Standard of care Standard therapy statistically significant statistically significant reduction Tocilizumab Treatment with COVID-19 [DOI] 10.1016/j.eclinm.2022.101489 [Article Type] Research article