Neuro-Axonal Damage and Alteration of Blood-Brain Barrier Integrity in COVID-19 PatientsCOVID-19 환자의 신경-축삭 손상 및 혈액-뇌 장벽 무결성의 변경Article Published on 2022-08-102022-09-11 Journal: Cells [Category] SARS, 치료기술, [키워드] absence alteration ARDS ARDS patient ARDS patients barrier Biomarker Blood blood-brain barrier CNS COVID-19 COVID-19 patient COVID-19 patients CSF damage ddPCR detectable discharge disease severity enzyme healthy donor healthy donors Hospitalization integrity involved light chain long-COVID matrix matrix metalloproteinases metalloproteinase MMPs neuro-COVID neurofilament neurofilament light chain Neurological symptom Neurological symptoms NfL Patient plasma plasma samples SARS-CoV-2 RNA SARS-CoV-2 RNA detection Zinc zymography zymography. [DOI] 10.3390/cells11162480 PMC 바로가기 [Article Type] Article
Risk factors for COVID-19 case fatality rate in people with type 1 and type 2 diabetes mellitus: A nationwide retrospective cohort study of 235,248 patients in the Russian FederationObservational Study Published on 2022-08-092022-10-05 Journal: Frontiers in Endocrinology [Category] 임상, [키워드] 95% confidence interval absence age agonist anti-COVID-19 vaccination association atherosclerotic BMI body mass index cardiovascular disease Case fatality rate CFR Chronic kidney disease CKD clinical information Combination COVID-19 COVID-19 case database death diabete Diabetes Mellitus Dipeptidyl peptidase-4 disease Factor fatality Fatality rate Federation Glucose-lowering drug glucose-lowering therapy. group Increased inhibitor inhibitors insulin Laboratory male Observational cohort study Odds ratio Older age outcome Patient patients positive receptor Registered retrospective cohort study risk risk factor risk of death therapy type 2 diabete vaccination Vaccine was performed were used [DOI] 10.3389/fendo.2022.909874 PMC 바로가기 [Article Type] Observational Study
USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STINGUSP22는 STING의 활성화를 통해 III형 인터페론 신호 전달 및 SARS-CoV-2 감염을 제어합니다Article Published on 2022-08-062022-09-11 Journal: Cell Death & Disease [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral basal causative agent Control COVID-19 pandemic de novo Defense enzyme epithelial cells exogenous IFN expression function Host identify IFN IFN signaling IFN-stimulated gene IFN-stimulated genes IFN-λ IFNs implication interferons interferons (IFNs interferons (IFNs) intestinal epithelial cell involved ISG ISGs long-lasting Particles pattern Pattern recognition Pattern recognition receptors PRRs receptor reversed SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections secretion Signaling STAT Stat1 STING tumorigenesis Type Type III IFN Type III IFNs type III interferon USP22 viral infection viral replication [DOI] 10.1038/s41419-022-05124-w PMC 바로가기 [Article Type] Article
Intranasal administration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing antibody levels and protects from experimental challenge infection in hamstersSARS-CoV-2 스파이크 단백질을 발현하는 약독화된 재조합 뉴캐슬병 바이러스의 비강내 투여는 높은 중화 항체 수준을 유도하고 햄스터의 실험적 공격 감염으로부터 보호합니다Article Published on 2022-08-052022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence activity administration affected booster vaccines candidate Complete COVID-19 COVID-19 pandemic COVID-19 vaccine demonstrated disease expressing full-length hamster histological induce Infection infection with SARS-CoV-2 injection intranasal Lower respiratory tract lung lesions NDV neutralizing antibody neutralizing antibody responses newcastle disease virus outbreak pre-fusion PROTECT Protein provided public health SARS-CoV-2 spike Spike protein suppressed the SARS-CoV-2 upper respiratory tract vaccination Vaccine Viral load virus Wuhan isolate [DOI] 10.1016/j.vaccine.2022.07.005 PMC 바로가기 [Article Type] Article
The Performance of SARS-CoV-2 Serology Testing in the Diagnosis of COVID-19Original Article Published on 2022-08-052022-10-29 Journal: Iranian Journal of Pathology [Category] COVID-19, [키워드] absence antibody blood sample collected COVID-19 cross-sectional determine diagnosing Diagnosis diagnosis of COVID-19 disease evaluate examined gold standard IgG IgM IgM and IgG Imam individual Iran pandemic Patient performance positive Prevalence proportion reference test replaced respiratory tract specimen RT-PCR RT-PCR test SARS-CoV-2 Sensitivity and specificity serology serology test specimen Symptoms Tehran Testing upper upper respiratory tract with COVID-19 [DOI] 10.30699/ijp.2021.526032.25971 PMC 바로가기 [Article Type] Original Article
Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1현재 순환 중인 Omicron SARS-CoV-2 하위 변이체 BA.2 및 BA.1.1에 대한 인간 ACE2의 더 높은 결합 친화도의 구조적 기초Article Published on 2022-08-042022-09-11 Journal: Cell [Category] COVID19(2023년), SARS, 변종, [키워드] absence Affect alteration angiotensin binding affinity binding pattern circulating complex structure complex structures contribute hACE2 highest human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Interaction Mutation mutations omicron RBD RBDs receptor-binding domains SARS-CoV-2 SARS-CoV-2 strains strain the receptor-binding domain the SARS-CoV-2 variants [DOI] 10.1016/j.cell.2022.06.023 PMC 바로가기 [Article Type] Article
Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry액체 크로마토그래피-탠덤 질량분석기를 이용한 SARS-CoV-2를 포함한 8종의 인간 호흡기 바이러스 동시 모니터링Article Published on 2022-08-042022-09-11 Journal: Scientific Reports [Category] SARS, 신종인플루엔자, 진단, 치료기술, 치료제, [키워드] 229E absence acute infection acute respiratory syndrome coronavirus applied Chain Reaction characterisation clinical sample clinical samples conditions coronavirus 2 Coverage Culture Diagnosis eight H1N1 H3N2 human respiratory virus Infection Influenza Influenza A/H1N1 influenza B information liquid Liquid chromatography mass spectrometry moderate not used nucleoprotein OC43 Orf9b peptide peptides polymerase chain polymerase chain reaction positive presence or absence Protein proteomics provide Replication respiratory respiratory virus respiratory viruses reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 ORF9b serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simultaneous specimens Tandem mass spectrometry the SARS-CoV-2 transcriptase viral infection Viral load Viral protein Viral proteins Viral RNA virus virus replication [DOI] 10.1038/s41598-022-16250-y PMC 바로가기 [Article Type] Article
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanismsSARS-CoV-2 RNA 의존성 RNA 중합효소의 돌연변이는 별개의 메커니즘으로 렘데시비르에 대한 내성을 부여합니다Article Published on 2022-08-032022-09-11 Journal: Science Translational Medicine [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Antiviral betacoronaviruses biochemical analysis biochemical pathway clinical settings Concentration consensus sequence consensus sequences coronavirus Critical defined demonstrated drug Drug administration Factor food Genetic greater GS-441524 half-maximal effective concentration Hepatitis homologous Increases increases in infections Lineage mechanism motif murine hepatitis virus Mutation nonstructural protein 12 nonsynonymous mutation Nonsynonymous mutations Nsp12 nucleoside overcome parent nucleoside passages phenotypic Prevent promote RdRP RDV Remdesivir Replication RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp Sequence analysis Ser severe acute respiratory syndrome Coronavirus Substitution substitutions substrate the SARS-CoV-2 to define Treatment triphosphate uridine triphosphate viral lineage [DOI] 10.1126/scitranslmed.abo0718 PMC 바로가기 [Article Type] Article
Therapeutic ultrasound versus injection of local anesthetic in the treatment of women with chronic pelvic pain secondary to abdominal myofascial syndrome: a randomized clinical trialRandomized Controlled Trial Published on 2022-08-022022-10-05 Journal: BMC Women's Health [Category] 임상, [키워드] abdomen abdominal pain absence analyzed cause characterized chronic clinical clinical trial Comorbidity conducted continuous pain Controlled clinical trial COVID-19 CPP defined dysfunction effective Efficacy evaluate evaluated Evidence exclusion groups IMPROVE injection Local Local anesthesia material Musculoskeletal Myofascial Myofascial pain syndrome no significant difference Pain Patient Pelvic Pelvic pain placebo group Quality of life questionnaire randomized clinical trial reducing Registered registry scale Study participants syndrome Tertiary therapeutic Therapeutic ultrasound Treatment Ultrasonic therapy Ultrasonic therapy. university variable Visual women [DOI] 10.1186/s12905-022-01910-y PMC 바로가기 [Article Type] Randomized Controlled Trial
COVID-19 in the absence of eosinophils: The outcome of confirmed SARS-CoV-2 infection whilst on treatment with benralizumab호산구가 없는 코로나19: 벤랄리주맙 치료 중 SARS-CoV-2 감염 확인 결과Article Published on 2022-08-012022-09-12 Journal: Allergy [Category] COVID19(2023년), SARS, 진단, [키워드] absence COVID-19 outcome SARS-COV-2 infection Treatment [DOI] 10.1111/all.15334 PMC 바로가기 [Article Type] Article