Synthesis and structure-activity relationship study of saponin-based membrane fusion inhibitors against SARS-CoV-2SARS-CoV-2에 대한 사포닌계 막융합 억제제의 합성 및 구조-활성 관계 연구Article Published on 2022-10-012022-09-11 Journal: Bioorganic chemistry [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral agent Antiviral agents antiviral efficacy Cell cell entry Cell fusion Complex molecule Complex molecules synthesis component Compound coronavirus coronavirus variants COVID-19 Critical derivative develop Effectiveness endosomal experiment fusion Glucose host cell host cell membranes inhibit inhibited inhibitor inhibitors membrane fusion protease Saponin saponins SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 variant SARS-CoV-2 variants Serine sugar synthesis the SARS-CoV-2 transmembrane [DOI] 10.1016/j.bioorg.2022.105985 PMC 바로가기 [Article Type] Article
Computational and experimental insights on the interaction of artemisinin, dihydroartemisinin and chloroquine with SARS-CoV-2 spike protein receptor-binding domain (RBD)Article Published on 2022-10-012022-11-15 Journal: Natural Product Research [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antimalarial Antiviral agents Artemisinin bind bio-layer interferometry Chloroquine complexes Compound computational tool Coronavirus disease-19 Coronavirus-2 COVID-19 demonstrated derivative docking study domain drug candidate host cell in vitro Interaction interfere Invasion investigated mechanism mechanisms metabolite molecular molecular dynamics predicted Protein RBD SARS-CoV-2 SARS-CoV-2 spike protein small molecule Spike protein stability treat [DOI] 10.1080/14786419.2021.1925894 PMC 바로가기
Non-Inferior Efficacy of Tenofovir Disoproxil to Tenofovir Disoproxil Fumarate in Virologically Suppressed Chronic Hepatitis B PatientsClinical Trial Published on 2022-09-232023-06-13 Journal: Drug design, development and therapy [Category] B형 간염, [키워드] Antiviral agents bone density viral DNA Viral suppression [DOI] 10.2147/DDDT.S376821 PMC 바로가기 [Article Type] Clinical Trial
Issues regarding COVID-19 in kidney transplantation in the ERA of the Omicron variant: a commentary by the ERA Descartes Working GroupArticle Published on 2022-09-222022-11-15 Journal: Nephrology, dialysis, transplantation : official p [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome ambulatory patients Antiviral Antiviral agents antiviral drug Breakthrough infection Clinical practice concerning coronavirus coronavirus disease COVID-19 criteria Deceased depleting Developing dominant donors drug-to-drug interactions education Efficacy European group immunization Immunosuppression implementation Infection issue kidney kidney donation kidney transplant recipient kidney transplant recipients Kidney transplantation management omicron Prophylactic question raised recommendation risk SARS-CoV-2 Science severe disease shielding T cell transplantation Treatment treatment strategy vaccination variant widespread with COVID-19 working [DOI] 10.1093/ndt/gfac203 PMC 바로가기
Discovery of 2-thiobenzimidazoles as noncovalent inhibitors of SARS-CoV-2 main proteaseSARS-CoV-2 주요 프로테아제의 비공유 억제제로서의 2-티오벤즈이미다졸의 발견Article Published on 2022-09-152022-09-11 Journal: Bioorganic & medicinal chemistry letters [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis antiviral agent Antiviral agents catalytic site conserved coronavirus antivirals COVID-19 pandemic docking effort in silico inhibitor inhibitors of SARS-CoV-2 inhibitory activity M pro Outbreaks predict predicted protease proteolytic protocol representing SARS-CoV-2 strain structures subset survival synthesis unique Virtual screening Zinc [DOI] 10.1016/j.bmcl.2022.128867 PMC 바로가기 [Article Type] Article
Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, MalawiArticle Published on 2022-09-132023-06-10 Journal: The Journal of Infectious Diseases [Category] B형 간염, Fulltext, [키워드] Africa Antiviral agents Epidemiology hepatitis B Malawi public health south of the Sahara vaccination [DOI] 10.1093/infdis/jiab562 PMC 바로가기
Important roles of transporters in the pharmacokinetics of anti-viral nucleoside/nucleotide analogsArticle Published on 2022-09-132024-09-04 Journal: Expert opinion on drug metabolism & toxicology [Category] 대상포진, [키워드] Antiviral agents drug transporter drug-drug interaction Genetic polymorphism nucleoside/nucleotide analogs pharmacokinetics [DOI] 10.1080/17425255.2022.2112175 PMC 바로가기 [Article Type] Article
The Antiviral Effects of 2-Deoxy-D-glucose (2-DG), a Dual D-Glucose and D-Mannose Mimetic, against SARS-CoV-2 and Other Highly Pathogenic VirusesArticle Published on 2022-09-122022-11-15 Journal: Molecules [Category] SARS, 유전자 메커니즘, 진단, 치료제, [키워드] 2-deoxy-D-glucose 2-DG Activation Antiviral agents antiviral drug cause Cell change changes changes in coronavirus D-Mannose Effect Glucose Glycolysis glycosylation host cell infected cell Infection Influenza virus inhibitors limit mechanism metabolic shift Mimetic noroviruses novel analogs Other pathway pharmacokinetic reduce respond rhinoviruses SARS-CoV-2 target Therapeutic approach upregulated viral infections Zika virus [DOI] 10.3390/molecules27185928 PMC 바로가기
Antiviral Activity of N1,N3-Disubstituted Uracil Derivatives against SARS-CoV-2 Variants of ConcernArticle Published on 2022-09-052022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 치료제, [키워드] activity addition antibody-based therapy Antiviral Antiviral agents antiviral drug Antiviral effect circulating circulating SARS-CoV-2 variants circulation Compound concern COVID-19 COVID-19 vaccines derivative effective Effectiveness infected with SARS-CoV-2 inhibit inhibitor non-nucleoside inhibitor. omicron Patient raise RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp significant decrease these compound Treatment uracil Variability variants of concern Vero E6 cell VoC VOCs widespread [DOI] 10.3390/ijms231710171 PMC 바로가기
A robust high-throughput fluorescence polarization assay for rapid screening of SARS-CoV-2 papain-like protease inhibitorsSARS-CoV-2 파파인 유사 프로테아제 억제제의 신속한 스크리닝을 위한 강력한 고처리량 형광 편광 분석Article Published on 2022-09-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 치료제, [키워드] Anacardic acid antiviral agent Antiviral agents cleavage competitive inhibitor COVID-19 develop disease effective therapy Fluorescence Fluorescence polarization functional High-throughput screening immune evasion in vitro inhibitor inhibitors lifecycle Papain Papain-like protease Papain-like protease inhibitors pathogen PLPro polyprotein protease protease inhibitors public health responsible robust SARS-CoV-2 Vaccines [DOI] 10.1016/j.virol.2022.07.006 PMC 바로가기 [Article Type] Article