SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cellsSARS-CoV-2 Omicron 변이체는 TMPRSS2 발현 세포에서 Delta 변이체와 비교할 때 복제 및 융합 활성이 덜 효율적입니다.Comparative Study Published on 2022-01-192022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] Affect Antiviral effect B.1.1.529 bafilomycin Calu3 CaLu3 cells camostat Cell cell line cells Characteristics Chloroquine clinical manifestation clinical manifestations competition Delta delta variant Delta variants disease severity Endocytic pathway entry pathway Immune escape Infection inhibit inhibited inhibiting less mutations not enhanced omicron Omicron variant replicated Replication robust SARS-CoV-2 Serine TMPRSS2 TMPRSS2 expression TMPRSS2 pathway transmembrane serine protease transmembrane serine protease 2 Transmissibility variant variants viral replication Virological [DOI] 10.1080/22221751.2021.2023329 PMC 바로가기 [Article Type] Comparative Study
Experience of Rwanda on COVID-19 Case Management: From Uncertainties to the Era of Neutralizing Monoclonal AntibodiesCOVID-19 사례 관리에 대한 르완다의 경험: 불확실성에서 단일 클론 항체 중화 시대까지Article Published on 2022-01-182022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 진단, 치료기술, [키워드] Anti-inflammatory drugs Antibiotic therapy anticoagulation Antiviral effect approach Asymptomatic bamlanivimab broad-spectrum antibiotic Care Case fatality rate Clinical management COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 therapeutics COVID-19 vaccine eligible patient Eligible patients experience Fatality rate Favipiravir guidelines Healthcare system hyperglycemia index case Intervention interventions management management guidelines measure Mild monoclonal antibodies neutralizing monoclonal antibodies neutralizing monoclonal antibody outcomes Patient provided receiving remained Rwanda therapeutic Therapeutic approach Therapeutics treated treatment for COVID-19 Uncertainty Viral viral clearance [DOI] 10.3390/ijerph19031023 PMC 바로가기 [Article Type] Article
Moxidectin and Ivermectin Inhibit SARS-CoV-2 Replication in Vero E6 Cells but Not in Human Primary Bronchial Epithelial Cells목시덱틴과 이버멕틴은 Vero E6 세포에서 SARS-CoV-2 복제를 억제하지만 인간의 1차 기관지 상피 세포에서는 억제하지 않습니다Article Published on 2022-01-182022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, 치료제, [키워드] ALI alleviate anti-parasitic Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral effect antiviral therapies bronchial caution Cell cell entry Concentration COVID-19 disease COVID-19 patient COVID-19 patients drug epithelial cells Evidence exhibited experiment following head Head-to-head comparison Health Organization High-dose Human humans in vitro in vitro model in vitro result in vivo Infection inhibit SARS-CoV-2 Interpretation Ivermectin limit Moxidectin moxidectin. performed regimen respiratory epithelial cells SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease shown switching therapy these compound these compounds treat Treatment triggered unlikely Vero Cell Vero cells Vero E6 VERO E6 cells virus World Health Organization [DOI] 10.1128/AAC.01543-21 PMC 바로가기 [Article Type] Article
Photodynamic Inactivation of Human CoronavirusesArticle Published on 2022-01-082022-10-28 Journal: Viruses [Category] COVID-19, [키워드] absence Antiviral antiviral activity Antiviral effect antiviral property assays Betacoronavirus concentrations coronavirus CoVs cultured cell damaged demonstrated digestion dose-dependent manner doses emodin expand experiments HCoV-229E HCoV-OC43 herpes simplex Human human cells human coronavirus inactivation inhibited lentivirus Local microorganisms natural product oxygen PDI photodynamic inactivation photosensitizer PhytoQuin prevented Protein pseudotyped reactive oxygen specy Replication RNase ROS S protein SARS-CoV-2 spike susceptible the SARS-CoV-2 Viral RNA virus viruses [DOI] 10.3390/v14010110 PMC 바로가기 [Article Type] Article
Antiviral activity of 5-aminolevulinic acid against variants of severe acute respiratory syndrome coronavirus 2Research Published on 2022-01-072022-10-28 Journal: Tropical Medicine and Health [Category] COVID-19, [키워드] 5-Ala accelerated activities acute respiratory syndrome Amino acid Anti-inflammatory anti-viral drug Antiviral antiviral activity antiviral drug Antiviral effect antiviral therapeutics Beta Cell clinical evaluation coronavirus coronavirus disease COVID-19 COVID-19 vaccines cytotoxicity Delta delta variant demonstrated effective exhibited Gamma in vitro infected with SARS-CoV-2 inhibit inhibited pandemic Patient quantified real time Result RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 Wuhan strain SFC sodium Strains Treatment variant variants VERO-E6 virus inhibition was determined Wuhan [DOI] 10.1186/s41182-021-00397-x PMC 바로가기 [Article Type] Research
Exploration of SARS-CoV-2 3CL pro Inhibitors by Virtual Screening Methods, FRET Detection, and CPE Assay가상 스크리닝 방법, FRET 감지 및 CPE 분석에 의한 SARS-CoV-2 3CL pro 억제제 탐색Article Published on 2021-12-272022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 치료기술, 치료제, [키워드] 3CL pro Algorithm Analysis Antiviral effect Bayesian binding mechanism biological activity caused CDOCKER component Compound compounds coronavirus COVID-19 CPE cross Cytopathic effect database detection determined by drugs eight energy transfer exploration half-maximal inhibitory concentration indicated information inhibiting inhibitor machine learning algorithm Machine learning algorithms machine learning model molecular naïve Novel coronavirus predicted protease Replication SARS-CoV-2 Screening scutellarein selected trihydroxyflavone two-dimensional was determined [DOI] 10.1021/acs.jcim.1c01089 PMC 바로가기 [Article Type] Article
Cysteamine with In Vitro Antiviral Activity and Immunomodulatory Effects Has the Potential to Be a Repurposing Drug Candidate for COVID-19 Therapy시험 관내 항 바이러스 활성 및 면역 조절 효과를 갖는 시스 티민은 COVID-19 요법에 대한 용도의 약물 후보가 될 가능성이있다.Article Published on 2021-12-242022-08-31 Journal: Cells [Category] SARS, 신약개발, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-inflammatory effect Antiviral antiviral action Antiviral effect antiviral effects applied assays Bacteria blood sample Blood samples calu-3 cells candidate caused coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patients COVID-19 therapy CPE cystamine cysteamine Cytopathic effect cytopathic effects decrease demonstrated determine Disulfide drug Drug repurposing Effect IFN-γ immune response immunomodulatory effects in vitro independent independent of investigated modulate Oxidation pandemic parasites Potential repurposing respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus significantly the SARS-CoV-2 therapy for COVID-19 these compound these compounds Treatment Vero E6 VERO E6 cells Viral viruses [DOI] 10.3390/cells11010052 PMC 바로가기 [Article Type] Article
Virucidal effect of povidone-iodine against SARS-CoV-2 in vitroArticle Published on 2021-12-162023-07-02 Journal: The Journal of international medical research [Category] SARS, [키워드] Antiviral effect povidone-iodine Prophylaxis public health SARS-CoV-2 [DOI] 10.1177/03000605211063695 PMC 바로가기
Polyethylene Films Containing Plant Extracts in the Polymer Matrix as Antibacterial and Antiviral MaterialsArticle Published on 2021-12-142022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] Φ6 phage active against active films active foils addition affected Analysis Antibacterial antibacterial properties antiviral activity Antiviral effect antiviral properties Bacillus subtilis Bacterial CO2 extracts Containing determine Escherichia coli exhibited Extract Features film functional Gram-negative bacteria growth indicated inhibit inhibited initial material matrix not affect offer parameter Particles PE films physicochemical plant plant extracts plants polyethylene Polymer polymer matrix pomegranate seeds Pseudomona Radiation raspberry seeds Research rosemary SARS-Co-V2 SARS-CoV-2 particles selected significantly Staphylococcus aureus strain [DOI] 10.3390/ijms222413438 PMC 바로가기 [Article Type] Article
Iota-Carrageenan Inhibits Replication of SARS-CoV-2 and the Respective Variants of Concern Alpha, Beta, Gamma and DeltaIota-Carrageenan은 SARS-CoV-2 및 우려되는 알파, 베타, 감마 및 델타의 각 변종 복제를 억제합니다Article Published on 2021-12-082022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 치료제, [키워드] age Alpha antiviral activity Antiviral effect Beta Calu Calu-3 can not carrageenan carrageenan types Carrageenans comparable concern contribute coronavirus COVID-19 COVID-19 pandemic Defense Delta effective exhibit Gamma human lung cell human lung cells independent independent of infect Infection inhibit investigated Iota iota-carrageenan kappa-carrageenan lack Lambda lambda-carrageenan lentivirus nasal Particle Prophylaxis pseudotyped pseudotyping public health threat reduce SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike Spread SSPL sulfated polymer sulfated polysaccharide sulfated polysaccharides supply the SARS-CoV-2 TMPRSS2 transgenic transmission of SARS-CoV-2 transmitted Treatment vaccination Vaccine Vaccine-induced immunity variants variants of concern Viral Viral transmission virulent virus variants VoC VOCs Wuhan [DOI] 10.3390/ijms222413202 PMC 바로가기 [Article Type] Article