Middle East respiratory syndrome (MERS): Emergence of a pathogenic human CoronavirusArticle Published on 2017-02-082023-05-31 Journal: Annual review of medicine [Category] MERS, 조류인플루엔자, [키워드] animal models antiviral therapies Camels host-virus interactions immune response outbreak [DOI] 10.1146/annurev-med-051215-031152 PMC 바로가기 [Article Type] Article
Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion CompetenceReview Published on 2012-04-122022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activate angiotensin converting enzyme 2 antiviral therapies Carcinoembryonic antigen cathepsin cofactor competence coronavirus Coronavirus infection endocytosis Endosomes fusion highlight Interaction interactions membrane fusion other protease protease Proteins receptor response S protein S proteins spike Spike protein transmembrane protease transmembrane serine protease triggers TTSPs viral pathogenesis viral spike virus virus entry virus-cell membrane fusion [DOI] 10.3390/v4040557 PMC 바로가기 [Article Type] Review
Identification of NCAM that interacts with the PHE-CoV spike proteinResearch Published on 2010-09-242022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] adhesion antibody antiviral therapies association binding blocked cDNA library Cell cells cellular cellular molecule coronavirus Critical double-stranded found identification Infection inhibited interact Interaction molecule Neural Protein required Result S glycoproteins S protein screened siRNA Spike protein T7 target target cells viral life cycle virus infection [DOI] 10.1186/1743-422X-7-254 PMC 바로가기 [Article Type] Research
MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoVResearch Article Published on 2008-12-122022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] 2003 absence adapter addition animal model antiviral therapies Atypical Author BALB/c mice C57BL/6 caused Cell characterized chemokine Chemokine receptor chest X-ray China circulating Clinical course compared contribute coronavirus coronavirus correlated Course CoV death disease disease pathogenesis early response exhibited expression Factor function Genetic greater Host host gene Host immune response humans identify immune immune system Infection Inflammatory Inflammatory response innate immune intranasal Laboratory lethal Lower respiratory tract lung Lung inflammation lung tissue Lungs mice monocyte monocytes/macrophage Mortality mouse-adapted SARS-CoV Pneumonia Post-infection Proinflammatory cytokine protection Protein provide Pulmonary pathology receptor recruitment Replication required respiratory virus respond SARS-CoV SARS-CoV infection severe lung pathology Signaling significantly higher Spread susceptible TLR Travel Viral load viral loads viral replication virus virus wild-type [DOI] 10.1371/journal.ppat.1000240 PMC 바로가기 [Article Type] Research Article
Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoproteinResearch Published on 2005-07-182023-08-29 Journal: Virology Journal [Category] E형 간염, [키워드] antiviral therapies envelope glycoprotein fusion Hendra virus Infection inhibition Nipah virus paramyxovirus [DOI] 10.1186/1743-422X-2-57 PMC 바로가기 [Article Type] Research