High SARS-CoV-2 load in the nasopharynx of patients with a mild form of COVID-19 is associated with clinical deterioration regardless of the hydroxychloroquine administration경미한 형태의 COVID-19 환자의 비인두에서 높은 SARS-CoV-2 로드는 하이드록시클로로퀸 투여와 상관없이 임상 악화와 관련이 있습니다Research Article Published on 2021-01-292022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] Anti-SARS-CoV-2 Activity Antiviral approved Arterial hypertension Clinical data Clinical deterioration clinically control group country COVID-19 COVID-19 infection COVID-19 infections deaths Deterioration disease dose drug evaluated Federation framework HCQ HCQ therapy Hydroxychloroquine hydroxychloroquine administration hypertension in vitro in vivo infected patient infected patients Medical conditions Mild Ministry of Health nasopharynx non-randomized observational study Pathologies Patient people with COVID-19 per day pharmacological Prophylaxis receiving reduced risk factor RNA Russia SARS-CoV-2 SARS-CoV-2 RNA shown statistically significant Support Swab Symptom the SARS-CoV-2 therapy treatment instructions Treatment protocol treatment protocols Viral viral RNA load viral shedding virus RNA while [DOI] 10.1371/journal.pone.0246396 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 genomic characterization and clinical manifestation of the COVID-19 outbreak in Uruguay우루과이에서 발생한 COVID-19 발병의 SARS-CoV-2 게놈 특성 및 임상 징후Coronaviruses Published on 2021-01-152022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Arterial hypertension association caused clade clinical correlations clinical parameter Cohort contribute coronavirus correlated correlation COVID-19 COVID-19 outbreak D614G D614G mutation disease dominance FIVE full genome amplicon sequencing Genetic genomic global public health global public health emergency Health Organization Healthcare system hypertension ICU admission independent Inpatients kidney Kidney failure Latin America Local make up minimum Mutation non-structural protein outbreak outcome outpatients and inpatient pandemic partial lockdown performed phylodynamic phylogeographic analysis phylogeographic BEAST analysis respiratory Respiratory illness resulting SARS-CoV-2 SARS-COV-2 infection sequence sequenced sequences severe acute respiratory syndrome Coronavirus significantly South South America spike D614G genetic mutation the SARS-CoV-2 Transmission transmission clusters transmissions Uruguay Viral viral genome viral genomes viral strain viral strains virus World Health Organization [DOI] 10.1080/22221751.2020.1863747 PMC 바로가기 [Article Type] Coronaviruses
COVID-19 e Injúria Miocárdica em UTI Brasileira: Alta Incidência e Maior Risco de Mortalidade Intra-HospitalarObservational Study Published on 2021-01-132022-10-04 Journal: Arquivos Brasileiros de Cardiologia [Category] MERS, 임상, [키워드] age Arterial hypertension Betacoronavírus, SARS – CoV-2 Betacoronavirus BMI body mass index Bra Brazil chi-square test conducted Coronaviírus coronavirus COVID-19 cut-off determine Hospitalização Hospitalization ICU identify in-hospital mortality incidence independent indicated Infarto do Miocárdio Infecção Infection Injury intensive care Kaplan-Meier Male sex Mann-Whitney Mann-Whitney U test massa Miocardite Morbidade morbidity Multivariate analysis Myocardial infarction myocardial injury myocarditis objective Occurrence pacientes com COVID-19 Patient patients patients with COVID-19 predict predictor predictors prognostic Result risk ROC ROC Curve SARS-CoV-2 severe COVID-19 student Student t test survival function systemic the Kaplan-Meier method troponin I UTI variable variables was determined was performed was used [DOI] 10.36660/abc.20200671 PMC 바로가기 [Article Type] Observational Study
Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomized, parallel-group, open-label, multi-center pilot trial (PROTECT-COVID-19)입원한 COVID-19 환자의 중증 SARS-CoV-2 감염 예방을 위한 재조합 인간 C1 에스테라제 억제제(conestat alfa): 무작위, 병렬 그룹, 공개 라벨, 다중 센터에 대한 연구 프로토콜의 구조화된 요약 파일럿 시험(PROTECT-COVID-19)Letter Published on 2021-01-042022-09-10 Journal: Trials [Category] 임상, [키워드] 24 hour 24 hours Activation activities acute lung injury addition adjusted Administered administration allergy Antibiotics anticipated anticoagulation arterial Arterial hypertension Basel Blinding BMI Brazil Breast Breast feeding breathing ambient air C-reactive protein C1 esterase inhibitor cardiovascular disease Caregivers changes in Chest Child-Pugh score chronic chronic pulmonary disease chronic renal disease cirrhosis class clinical Clinical improvement clinical trial comparator comparator Patients complement complement system completion conducted Conestat alfa Contact contact activation system contraindication control group Corticosteroids COVID-19 COVID-19 patient CT scan death defined discharge disease disease severity dissemination drug Duration Efficacy and safety element eligibility enrolment evidence of experimental arm family members FIVE followed by history hospital Hospitalization hospitalized patient hypertension ICU IL-6 inhibitor IL-6R improvement Incapacity include inclusion criteria individual Infection inflammatory cascade inflammatory cascades inflammatory proteins inhibitor Interactive Web Response System interim analysis Intravenous injection invasive invasive or non-invasive ventilation investigator-initiated investigators kallikrein kinin system laboratory parameter Liver cirrhosis Local Lung injury mechanical ventilation non-invasive ventilation not blinded number obesity objective Open-label open-label trial Ordinal Scale outcome outcome assessor outcome assessors oxygen oxygen saturation pandemic PaO parallel-group participant Participants Participation Patient performed Pregnancy primary endpoint progression proportion protocol pulmonary disease pulmonary involvement randomised randomization Randomized randomized trial receive recombinant recruited recruitment Registered Remdesivir renal renal disease required risk factor Sample size SARS-COV-2 infection SARS-CoV-2 pandemic scale screened secondary Secondary outcomes severe COVID-19 severe SARS-CoV-2 Standard of care status Study protocol subject supplemental oxygen supplementary material suspicion Switzerland Symptom the SARS-CoV-2 the WHO their family members Tocilizumab Treatment treatment arm Trial Two interim analyses Two interim analysis virological clearance website WHO WHO ordinal scale with COVID-19 X-ray [DOI] 10.1186/s13063-020-04976-x PMC 바로가기 [Article Type] Letter
Clinical Characteristics and Outcomes of Patients with COVID-19 Infection: The Results of the SARS-RAS Study of the Italian Society of HypertensionPractice Guideline Published on 2021-01-012022-10-05 Journal: High blood pressure & cardiovascular prevention : [Category] 임상, [키워드] Analysis Anti-hypertensive therapy Arterial hypertension clinical Comorbidities contributed COVID-19 infection epidemiological frailty help Infection Interaction Italian knowledge management morbidity Mortality multicentre National pandemic renin-angiotensin system Result SARS-CoV2 second wave Sex-differences significantly Society Spread the disease with COVID-19 [DOI] 10.1007/s40292-020-00429-3 PMC 바로가기 [Article Type] Practice Guideline
COVID-19 in people living with HIV: A multicenter case-series studyObservational Study Published on 2021-01-012022-10-05 Journal: International Journal of Infectious Diseases [Category] 임상, [키워드] Affect age analyzed Antiretroviral therapy Arterial hypertension ARV association Comorbidities conducted cough COVID-19 COVID-19 patients determinant Diabetes Mellitus Dyspnea Factor Fever global mortality HIV HIV infection HIV patient HIV-negative hospital Hospitalization ICU admission infected patients Infection lower mortality median median age men mortality rate multicenter outcome Patient patients patients with HIV PLHIV Prognostic factor prospective cohort Public Hospital SARS-CoV-2 severe disease severity severity of COVID-19 Symptom Treatment with COVID-19 with HIV [DOI] 10.1016/j.ijid.2020.10.060 PMC 바로가기 [Article Type] Observational Study
COVID-19 and Acute Kidney Injury: A Systematic Review and Meta-AnalysisReview Published on 2020-12-152022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] 95% CI Acute kidney injury adopted age AKI analyses Arterial hypertension calculated caused clinical study coronavirus disease COVID-19 COVID-19 patient COVID-19 positive patient death Deceased dialysis Egger’s test evaluate Frequency greater heterogeneity Hospitalization hospitalized COVID-19 incidence Kidney injury mechanism Meta-analysis meta-regression morbidity and mortality Mortality occurred Occurrence Odds ratio outcomes pandemic Patient patients patients with COVID-19 performed positive patients preliminary evidence random-effects model renal replacement therapy retrieved review risk RRT SARS-CoV-2 severe COVID-19 severe disease Significant stratified Survivors systematic review unique [DOI] 10.3390/pathogens9121052 PMC 바로가기 [Article Type] Review
Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 PathologyReview Article Published on 2020-12-042022-10-29 Journal: International Journal of Hypertension [Category] COVID-19, [키워드] ACE2 ACE2 gene Admission angiotensin-converting enzyme 2 arterial Arterial hypertension blood pressure caused Clinical data Complication contribute Coronavirus disease 2019 Course COVID-19 COVID-19 infection COVID-19 patients current Cytokine storm dysregulation global public health hypertensive patient ICU immune system intensive care mechanism MONITOR Novel coronavirus outcome pathophysiology polymorphism poor prognosis question receive resulting risk SARS-CoV-2 SARS-COV-2 infection Subtypes T helper cell with COVID-19 [DOI] 10.1155/2020/8019360 PMC 바로가기 [Article Type] Review Article
A Survey-based Estimate of COVID-19 Incidence and Outcomes among Patients with Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension and Impact on the Process of Care폐동맥 고혈압 또는 만성 혈전 색전성 폐 고혈압 환자의 COVID-19 발병률 및 결과 및 치료 과정에 대한 영향에 대한 설문 조사 기반 추정Article Published on 2020-12-012022-09-11 Journal: Annals of the American Thoracic Society [Category] MERS, 진단, 치료제, [키워드] appear arterial Arterial hypertension chronic clinic operations Clinic visits clinical evaluation coronavirus coronavirus disease COVID-19 cumulative cumulative incidence Descriptive analyses Descriptive analysis diagnosed with COVID-19 diagnostic diagnostic testing died estimate evaluate General population Hospitalized hypertension Impact incidence incidence of COVID-19 individual Linear regression majority management MOST outcome outcomes PAH pandemic Patient patients Process pulmonary pulmonary arterial hypertension pulmonary hypertension rationale telehealth therapy thromboembolic Treatment undergo vascular disease were used [DOI] 10.1513/AnnalsATS.202005-521OC PMC 바로가기 [Article Type] Article
Guidance for the Management of Patients with Vascular Disease or Cardiovascular Risk Factors and COVID-19: Position Paper from VAS-European Independent Foundation in Angiology/Vascular Medicine혈관 질환 또는 심혈관 위험 인자 및 COVID-19가 있는 환자의 관리를 위한 지침: VAS-European Independent Foundation in Angiology/Vascular Medicine의 입장 보고서Review Published on 2020-12-012022-09-12 Journal: Thrombosis and haemostasis [Category] MERS, SARS, 진단, [키워드] advanced age Antithrombotic Antiviral Arterial hypertension cardiovascular cardiovascular disease cardiovascular risk factor Care Community COVID-19 D-dimer Diabetes Mellitus disease disease symptoms eHealth technology Epidemic Factor Follow-up foundation Health high risk hospital discharge Hospitalization hospitalized patient hypercoagulability intermediate dose intravascular coagulation LMWH Male sex management manifested Medicine obesity oral anticoagulant paper Patient physical position progression receive risk risk factor severe COVID-19 Social distancing measure Thromboprophylaxis thrombosis Treatment treatment for COVID-19 unfractionated heparin Vascular vascular disease Venous Thromboembolism VTE VTE risk worsening [DOI] 10.1055/s-0040-1715798 PMC 바로가기 [Article Type] Review