AST – Page 8 – Communicable Diseases Research

Clinical laboratory evaluation of COVID-19

COVID-19의 임상 실험실 평가

Review

Published on 2021-08-012022-09-11
Journal: Clinica chimica acta; international journal of cli [Category] SARS, 바이오마커, 치료기술,

Correlation of Viral Load With the Clinical and Biochemical Profiles of COVID-19 Patients

Infectious Disease

Published on 2021-07-272022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] acute respiratory syndrome Alanine albumin ALP ALT analyzed Aspartate aminotransferase AST Bilirubin biochemical biochemical parameter Biochemical parameters calculated caused chi-square test clinical clinical parameter Clinical severity coronavirus correlated correlation COVID 19 COVID-19 COVID-19 patients cross-sectional CRP cycle threshold D-dimer disease Disease progression disease severity ferritin group IBM Infectious disease lactate dehydrogenase LDH leucocyte load lymphocyte Mild moderate Patient PCT profile Protein Result retrospective RT-PCR SARS-CoV-2 severity shown single-center study SPSS statistically statistically significant the disease three group variations Viral load was done was used with COVID-19
[DOI] 10.7759/cureus.16655 PMC 바로가기 [Article Type] Infectious Disease

Single-cell analysis reveals cell communication triggered by macrophages associated with the reduction and exhaustion of CD8 + T cells in COVID-19

단일 세포 분석은 COVID-19에서 CD8 + T 세포의 감소 및 고갈과 관련된 대식세포에 의해 촉발된 세포 통신을 보여줍니다

Observational Study

Published on 2021-07-082022-09-12
Journal: Cell Communication and Signaling : CCS [Category] 임상, 진단,

[키워드] activity acute respiratory syndrome Algorithm Analysis analyzed AST AUROC Bronchoalveolar lavage fluid calculate caused CD4 CD8 Cell cell types cellular clinical collected composed condition contributed coronavirus coronavirus disease COVID-19 COVID-19 pathogenesis COVID-19 patients CXCL10 cytokine D-dimer demonstrated described driving Efficacy enrolled Flow cytometry analysis functional heterogeneity hospitalized patient hypoxia IGF1 IL10 IL1β IL6 Immune cell IMPROVE independent risk factor Infection Inflammatory information Interaction interactions Laboratory tests Logistic regression analysis Macrophage Measures microenvironment moderate disease molecular mechanism multivariate offer outbreak outcome pandemic parameters pathway Patient Predictive ranged reduction respiratory immune Result retrospective reveal risk SARS-CoV-2 scRNA-seq data selective serum cytokine severe disease severity of COVID-19 significantly lower Single cell RNA-sequencing single-cell single-cell analysis subtype supplementary material T cell T cell subset T cells target therapy TNFα Trial registration triggered understanding Vaccines was used WBC Weighting were measured
[DOI] 10.1186/s12964-021-00754-7 PMC 바로가기 [Article Type] Observational Study

Effect of curcumin-pipeine supplementation on clinical status, mortality rate, oxidative stress, and inflammatory markers in critically ill ICU patients with COVID-19: a structured summary of a study protocol for a randomized controlled trial

COVID-19가 있는 중환자 중환자실 환자의 임상 상태, 사망률, 산화 스트레스 및 염증 지표에 대한 커큐민-피페인 보충제의 효과: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-07-062022-09-10
Journal: Trials [Category] SARS, 임상,

[키워드] 1:1 addition Administered All participants allocation sequence ALT anticipated Anticoagulant assigned AST baseline Blinding Blood oxygen saturation C-reactive protein Capsule clinical clinical status Clinical symptoms clinical trial clinical trials CLOCK collected color conducted congenital disorders control group coronavirus COVID-19 creatinine Critically ill CRP Curcumin definitive diagnosis Diseases disorders dissemination double-blind drug Effect Efficacy element eligible patient enteral feeding erythrocyte sedimentation erythrocyte sedimentation rate ESR exclusion criteria Factors female Fever File Hepatic insufficiency hospital ICU ICU patient ICU Patients immune include inclusion criteria independent Inflammatory marker intensive care intensive care unit Intervention intervention group investigators Iran kidney function marker kidney function markers labeling LDH liver male maltodextrin marker matching placebo Medical Sciences Mortality mortality rate normalization number Nurses objective odor outcome oxidative stress oxygen Pancreatitis parameter parenteral nutrition participant Participants Patient PCR test performed physician Physicians piperine Placebo placebo group placebo-controlled Primary outcome protocol provided random randomised randomised controlled trial Randomized Randomized controlled trial Randomly receive recruited Registered registration date registration number registry renal respiratory rate Sample size sealed secondary outcome Secondary outcomes sedimentation rate sensitivity sequence Seven Sex shape status Stratification stratified block randomization study participant Study participants Study protocol supplementary material Support Tablet Taste temperature the placebo group title Trial Trial registration turmeric underlying disease underlying diseases university ventilator Version Warfarin website weight
[DOI] 10.1186/s13063-021-05372-9 PMC 바로가기 [Article Type] Letter

Abnormal Liver Biochemistry Tests and Acute Liver Injury in COVID-19 Patients: Current Evidence and Potential Pathogenesis

Review

Published on 2021-07-012022-11-01
Journal: Diseases [Category] COVID-19,

[키워드] Acute acute respiratory syndrome alanine aminotransferase alkaline phosphatase ALP ALT Aspartate aminotransferase AST Biochemistry Cancer Care cause Cell chronic disease cirrhosis Clinical outcome conducted coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients current develop disease disease severity drugs function Health care system Hepatitis hepatocellular Hepatocellular carcinoma hepatocytes hypoxia impacted incidence individual Infection Injury involved liver Liver injury Mortality Pathogenesis pathogenic mechanism Potential Prognostic marker resulting SARS-CoV-2 serum severity Significant systematic review systemic inflammatory response Test tests the disease therapeutic total bilirubin
[DOI] 10.3390/diseases9030050 PMC 바로가기 [Article Type] Review

Intravenous administration of anakinra in children with macrophage activation syndrome

Short Report

Published on 2021-06-292022-10-29
Journal: Pediatric Rheumatology Online Journal [Category] Coronavirus, MERS, SARS,

Abnormal Coagulation Function of Patients With COVID-19 Is Significantly Related to Hypocalcemia and Severe Inflammation

Medicine

Published on 2021-06-162022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] Admission AST Blood Blood coagulation C-reactive protein calcitonin Chest CT image China CK-MB Clinical characteristics coagulation dysfunction coagulation function compared and analyzed Concentration correlated COVID 19 COVID-19 COVID-19 infected patient COVID-19 patient CRP D-dimer Decreased Degradation detect Diagnosis Electrolytes enrolled erythrocyte sedimentation rate ESR exhibited Fever function functions Ground glass opacity Hypocalcemia IL-6 increase in infected patients Infection Inflammation Inflammatory factor inflammatory factors information Jin Kidney function Laboratory test LDH liver lung metabolic disorder metabolic dysfunction Mild mild cases mild infection MOST myocardial enzymes New coronavirus Older patchy Patient PCT Pneumonia positively correlated procalcitonin routine blood tests serum calcium Severe case severe cases Severe COVID-19 Infection severe COVID-19 infections Severe infection significant decrease significant increase significantly systemic inflammation Treatment Trial Wuhan Wuhan, China X-ray
[DOI] 10.3389/fmed.2021.638194 PMC 바로가기 [Article Type] Medicine

Differential Diagnosis of COVID-19 Pneumonia From Influenza A (H1N1) Pneumonia Using a Model Based on Clinicoradiologic Features

Medicine

Published on 2021-06-152022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] Accuracy Admission age Aspartate aminotransferase AST AUC Chest CT clinical feature Cohort Computed tomography consolidation contagious diseases coronavirus disease Coronavirus disease 2019 COVID-19 develop differential diagnosis distribution eight elevated enrolled facilitate feature Fever generate H1N1 hospitals influenza A influenza A (H1N1) initial Logistic regression Logistic regression analysis Model Multivariate analysis Older age operator Patient patients with COVID-19 Pneumonia Randomly receiver operating characteristic ROC sensitivity specificity validation cohort validation cohorts with COVID-19
[DOI] 10.3389/fmed.2021.651556 PMC 바로가기 [Article Type] Medicine

Abnormal Liver Function Tests Were Associated With Adverse Clinical Outcomes: An Observational Cohort Study of 2,912 Patients With COVID-19

Medicine

Published on 2021-06-092022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] 95%CI abnormality adjusted Admission Adverse adverse outcomes alanine aminotransferase albumin alkaline phosphatase ALP ALT Aspartate aminotransferase association AST baseline China clinical Clinical outcome collected data confounders consecutive patient coronavirus disease coronavirus disease-2019 COVID-19 Cox regression models died function homogeneous hospital Hospitalization hospitalized patient ICU ICU admission increased risk Infection intensive care large cohort Liver function liver function test abnormality mechanical ventilation median Mortality outcome outcomes parameter Patient patients required severe acute respiratory syndrome coronavirus 2 severity of COVID-19 significantly Test total bilirubin was measured with COVID-19
[DOI] 10.3389/fmed.2021.639855 PMC 바로가기 [Article Type] Medicine

Cytokine/Chemokine Expression Is Closely Associated Disease Severity of Human Adenovirus Infections in Immunocompetent Adults and Predicts Disease Progression

Immunology

Published on 2021-06-072022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, 신종인플루엔자,

[키워드] “cytokine storm” acute respiratory disease acute respiratory distress alanine aminotransferase ALT analyses analyzed ARDS Aspartate aminotransferase AST AUC AUC value Bacteria Biomarker caused characteristic characterized Combination coronavirus Cytokine storm cytokine/chemokine expression disease Disease progression disease severity expression H1N1 healthy controls hepatocyte growth factor HGF highest Human human adenoviruses IFN-γ IL-10 IL-1α IL-1β IL-6 immunocompetent adults Increasing Infection infections interferon M-CSF MIG occurred outcome oxygen pandemic PaO Patient patients patients with ARDS plasma sample predict prediction Prevalence profile progression reached reported ROC SARS-CoV-2 significantly significantly higher syndrome Viremia were measured
[DOI] 10.3389/fimmu.2021.691879 PMC 바로가기 [Article Type] Immunology