The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic ApproachesArticle Published on 2022-09-132022-11-16 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Adapted CAMP Cancer cardiovascular diseases cascade cellular cGMP complex complexity contribute COVID-19 cyclic cyclic nucleotide phosphodiesterase (PDE) Depression diabetes disease drug design dysregulation emesis Evolution Fatty liver increases in Inflammation inhibitor Interaction interactome knowledge maintain malignancies multiplicity New nucleotide obesity organ Osteoporosis overcome pathologic Pathologies phosphodiesterase Phosphorylation physiological state problems receptors Regulation Research selective selective PDE4 inhibitor (PDE4-I). Signaling Specific subcellular Therapeutic approach tissue ulcerative colitis variant various tissue [DOI] 10.3390/ijms231810616 PMC 바로가기
Association between Vitamin D Status and Risk of Developing Severe COVID-19 Infection: A Meta-Analysis of Observational StudiesArticle Published on 2022-09-012022-11-15 Journal: Journal of the American Nutrition Association [Category] 바이오마커, [키워드] 25-hydroxyvitamin D3 95% CI age analyzed association Biomarkers C-reactive protein cardiovascular diseases Concentration conducted Controlled trial COVID-19 COVID-19 infection COVID-19 patient COVID-19 severity death deaths defined Developing Effect elevated eligibility Evidence examined greater higher risk Hospital stay hypertension IMPROVE increased risk independent Inflammatory interleukin-6 Invasive mechanical ventilation investigator male marker mechanism Meta-analysis observational study outcome outcomes participant pathway Patient peak D-dimer Prevalence Research risk serum serum troponin severe COVID-19 Severe COVID-19 Infection Severe COVID-19 pneumonia severity statistically status the patient Vitamin D vitamin D insufficiency vitamin D level vitamin D levels Vitamin D status [DOI] 10.1080/07315724.2021.1951891 PMC 바로가기
The sex and gender dimensions of COVID-19: A narrative review of the potential underlying factorsReview article Published on 2022-09-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE-2 ACE-2 receptor addition airway alcohol Biological difference cardiovascular diseases cells complex interplay coronavirus disease COVID-19 diabetes dimension discrepancy disorders downregulating Estrogen Evidence exhibited expression Factor Factors female females Gender Gender disparities health regulations Hormones immune response increase Infection involved kidney lung male Male sex males men men and women Mortality Multiple outcome outcomes progesterone protective role reduced risk risk factor Risk factors robust severe disease severity of COVID-19 Sex smoking Sociocultural effects statistically the SARS-CoV-2 viral infections virus with COVID-19 women [DOI] 10.1016/j.meegid.2022.105338 [Article Type] Review article
COVID-19 mortality surveillance in Lebanon Research Published on 2022-08-272022-10-05 Journal: Scientific Reports [Category] 치료기술, [키워드] Analysis Cancer cardiovascular disease cardiovascular diseases case fatality ratio CFR Characteristics Comorbidity confirmed case contribute COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19-related death CRF cumulative mortality death deaths described Descriptive analysis diabete diabetes dialysis distribution epidemiological epidemiological surveillance Health hospital hypertension implementation Improving Kidney disease Kidney diseases liver diseases Lung disease Lung diseases male Mortality mortality data mortality rate occurred Public re-emerging disease reported resource retrospective Surveillance this system was performed [DOI] 10.1038/s41598-022-18715-6 [Article Type] Research
Smart Diagnostics: Combining Artificial Intelligence and In Vitro DiagnosticsArticle Published on 2022-08-242022-11-15 Journal: Sensors (Basel, Switzerland) [Category] 진단, [키워드] artificial artificial intelligence biochemical analysis Biomarker bladder Cancer cancers cardiovascular diseases Care cartridge clinical decision clinical decision support tool clinical study clinically COVID-19 cross-reactive cytology diagnostic diagnostics disease disease detection disease severity Effect essential element Health healthcare identify Image analysis immunoassay IMPROVE in vitro in vitro diagnostics intelligence lab lab on a chip lung management multiplex oncology outcome Patient care Perspective platform point of care reported score SmaRT Support the patient trajectory Universal utility [DOI] 10.3390/s22176355 PMC 바로가기
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individualsarticle Published on 2022-08-092024-09-02 Journal: Nature Communications [Category] 대상포진, [키워드] cardiovascular diseases Medical genetics Predictive medicine [DOI] 10.1038/s41467-022-32095-5 PMC 바로가기 [Article Type] article
Gene Variants Related to Cardiovascular and Pulmonary Diseases May Correlate with Severe Outcome of COVID-19심혈관 및 폐 질환과 관련된 유전자 변이가 COVID-19의 심각한 결과와 관련될 수 있음Article Published on 2022-08-042022-09-11 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Analysis association cardiovascular cardiovascular diseases Cohort collected correlated COVID-19 COVID-19 patients CVD DRC1 Genetic Genetic variant genetic variants GWAS HADHA identified variant INDEL individual introns nucleotide outcome Poland polymorphism Protective pulmonary pulmonary disease pulmonary diseases risk Risk factors single nucleotide Single nucleotide polymorphism SNP SNPs subset variant variants was performed was used WGS whole-genome sequencing [DOI] 10.3390/ijms23158696 PMC 바로가기 [Article Type] Article
Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics Reviews Published on 2022-08-022022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 치료제, [키워드] atherosclerotic atherosclerotic lesion benefit Cancer cancers cardiovascular disease cardiovascular diseases cardiovascular event cardiovascular system Cell cholesterol cholesterol homeostasis cholesteryl esters clinics Critical CVD diabetes disease Diseases Disturbed endothelial events Health inhibiting Intervention Lipid Low-Density Lipoprotein cholesterol maintaining mechanism molecular neurodegenerative nonalcoholic fatty liver obesity Osteoporosis pathway preclinical study Prevent PROTECT Regulation regulatory pathways Research shown target Transport Treatment virus infection [DOI] 10.1038/s41392-022-01125-5 [Article Type] Reviews
Hypocalcemia: A key biomarker in hospitalized COVID-19 patientsResearch article Published on 2022-08-012022-10-05 Journal: Biomedical journal [Category] SARS, 바이오마커, [키워드] addition Admission adult subject Arterial hypertension association Biochemical biomarkers Biomarker blood biochemical calcium calcium concentration Cancer cardiovascular diseases China Chronic diseases Chronic kidney disease chronic obstructive CKD clinical complication Cohort collected Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CVD diabetes effective enrolled evaluated hospital hospitalizations hospitalized COVID-19 patient Hypocalcemia identify indicated ionized calcium mandatory material mechanical ventilation obesity outcome parameter Pathologies pathology patients poor prognosis positive correlation presence of comorbidity Previous studies profile Prognosis prognostic biomarker pulmonary disease Result SARS-CoV2 serum severity syndrome the disease [DOI] 10.1016/j.bj.2022.08.005 [Article Type] Research article
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patientsAPOE는 ACE2와 상호작용하여 COVID-19 환자에서 SARS-CoV-2 세포 진입 및 염증을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] ACE2 addition Affect allele ApoE APOE4 Apolipoprotein Apolipoprotein e assays binding binding affinity cardiovascular diseases carrier carriers cells cellular entry chemokine cholesterol cholesterol metabolism clinically comparable Concentration COVID-19 infection COVID-19 patient COVID-19 patients disease severity docking domain elevated explain genetic risk factor Infection Inflammation Inflammatory factor inhibit inhibiting interact Interaction isoform Lipid mechanism metabolism Protein receptor reduce Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein serum serum concentrations spike Spike protein susceptibility the SARS-CoV-2 transmission electron microscopy viral entry viruses Zinc [DOI] 10.1038/s41392-022-01118-4 PMC 바로가기 [Article Type] Article