Creating symptom-based criteria for diagnostic testing: a case study based on a multivariate analysis of data collected during the first wave of the COVID-19 pandemic in New ZealandResearch Published on 2021-10-302022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] age Ageusia Algorithm Algorithms analysed Analysis Anosmia approach automated Bayesian class clinical collected conditions correspondence COVID-19 COVID-19 pandemic criteria decision demographic data Demographic variables determine diagnostic diagnostic testing Epidemiology explained Fever First wave forest headache Health services individual individuals Infection joint Latent machine learning Machine learning algorithms Multiple New outcomes Pain PCR PCR-confirmed presenting proportion provided public health reduced resource respiratory symptom Result sensitivity Sensitivity and specificity Sex Shortness of breath sore throat specificity supplementary material Symptom symptomatic Symptoms tested Travel tree Triaging weakness worsening cough [DOI] 10.1186/s12879-021-06810-4 PMC 바로가기 [Article Type] Research
Subtypes of nurses’ mental workload and interaction patterns with fatigue and work engagement during coronavirus disease 2019 (COVID-19) outbreak: A latent class analysisResearch Article Published on 2021-10-222022-10-28 Journal: BMC Nursing [Category] COVID-19, [키워드] Analysis analyzed ANCOVA Care class cognitive Comparisons complex conducted contributed coronavirus disease COVID-19 COVID-19 outbreak Critical cross-sectional Demographic variables Diseases Engagement Epidemic fatigue group Health index indicated interaction pattern latent class latent class analysis load Logistic medium Mental Mental workload Multivariate analysis NASA Nurse Nurses Older Patient performed physical public health questionnaire raise response Result risk scale significantly higher subgroup subgroups subtype were used work Work engagement [DOI] 10.1186/s12912-021-00726-9 PMC 바로가기 [Article Type] Research Article
Potential Novel Thioether-Amide or Guanidine-Linker Class of SARS-CoV-2 Virus RNA-Dependent RNA Polymerase Inhibitors Identified by High-Throughput Virtual Screening Coupled to Free-Energy CalculationsArticle Published on 2021-10-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] absence acute respiratory syndrome antiviral drugs binding free energy binding site identification calculated calculation caused class Compound Coronaviridae coronavirus COVID-19 COVID-19 disease database docking drug target effective energy Ensemble docking free-energy calculations global pandemic Identified in silico in silico drug design in vitro inhibitor molecular dynamics Molecular dynamics simulation non-covalent inhibitors novel pathogen performed Potential RdRP RdRp inhibitor representing Research RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 virus Screening the SARS-CoV-2 therapeutic target unique Viral protein Virtual screening [DOI] 10.3390/ijms222011143 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development자연 발생 파이토케미칼로 코로나19의 SARS-CoV-2 스파이크 단백질 표적화: 약물 개발을 위한 in silico 연구Article Published on 2021-10-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] ACE2 ACE2 receptor ACE2 receptors addition ADME Analysis angiotensin Angiotensin-converting enzyme anti-SARS-CoV-2 approved attachment binding binding free energy cascade cell surface receptor class class I fusion protein complex Compound COVID-19 disease drug-likeness engage enzyme FDA Fisetin flavonoids flavonoids and non-flavonoids free energy fusion fusion protein glycoprotein hACE2 HCQ Host host cell host cell surface host cells Hydroxychloroquine in silico indication Infection internalization membrane fusion molecular molecular docking molecular docking studies Molecular docking study molecular dynamics performed phytochemicals pre-fusion provided quercetin receptor Recognition SARS-CoV-2 SARS-CoV-2 spike protein spike spike glycoprotein Spike protein suggested targeting the SARS-CoV-2 tissue tropism transition Trigger viral envelope viral infection virus [DOI] 10.1080/07391102.2020.1796811 PMC 바로가기 [Article Type] Article
Targeting intra-viral conserved nucleocapsid (N) proteins as novel vaccines against SARS-CoVsSARS-COV에 대한 새로운 백신으로서 바이러스 내 보존 된 뉴 클레오 캡시드 (N) 단백질을 표적으로Virology Published on 2021-09-302022-09-01 Journal: Bioscience Reports [Category] SARS, 변종, 진단, 치료법, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus against SARS-CoV anti-N antibodies anti-N antibody antibody B-cell caused CCL5 class conserved conserved regions coronavirus coronavirus disease Coronaviruses CoV COVID-19 CoVs cytokine Cytokines disease effort elevated ELISA assay epitope Evolution exhibited global pandemic host immune system humanized IFN-γ IgG IgG1 IgG2a IgM immune Immunity memory T cell memory T cells mice mouse monoclonal antibody multiple mutation multiple mutations mutant strain Mutant strains mutated virus N-protein nucleocapsid nucleocapsid protein Patient peptide peptides Protein Region respiratory response robust S protein SARS-CoV SARS-CoV-2 sera severe acute respiratory syndrome coronavirus 2 spike Spread stimulate stimulated strain T cells targeting treat vaccination Vaccine vaccine candidate [DOI] 10.1042/BSR20211491 PMC 바로가기 [Article Type] Virology
Feasibility of a surveillance programme based on gargle samples and pool testing to prevent SARS-CoV-2 outbreaks in schools학교에서 SARS-COV-2 발병을 방지하기위한 양수 샘플 및 수영장 테스트를 기반으로 한 감시 프로그램의 타당성Article Published on 2021-09-302022-09-10 Journal: Scientific Reports [Category] 치료기술, [키워드] acceptance Algorithm Asymptomatic children class detect Disease prevention extracted RNA feasibility feasible FIVE gargle Germany implementation indicated Infection lead likelihood logistics Mental MONITOR open outbreak participant participated Participation physical Policy and public health in microbiology positive positive response Prevent pupil Pupils questionnaire Research respiratory respiratory tract infection response response rate SARS-CoV-2 SARS-COV-2 infection School Schools secondary school selected Support Surveillance Viral transmission [DOI] 10.1038/s41598-021-98849-1 PMC 바로가기 [Article Type] Article
Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodiesCOVID-19 기증자 유래 중화 항체의 하위 집합에 의해 나타나는 사베코바이러스 전반에 걸친 광범위한 교차 반응성Article Published on 2021-09-282022-09-11 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-RBD antibodies Anti-RBD antibody anti-SARS-CoV-2 antibody avidity binding site breadth CDRH3 changes class coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity crosslinking cryo cryo-EM Donor epitope Epitopes exhibited facilitate H-bond interaction neutralization Neutralizing Neutralizing antibodies neutralizing antibody occlude potent RBD RBD-binding antibody RBDs Receptor-binding domain recognize reducing respiratory reveal sarbecovirus SARS-CoV-2 SARS-CoV-2 variants sensitivity spike spike trimer Spike trimer: structural biology structural biology Structure subset trimer Vaccine design variants Viral viral spike Virology virology: X-ray crystallography. X-ray crystallography Zoonotic coronavirus zoonotic coronaviruses zoonotic sarbecovirus [DOI] 10.1016/j.celrep.2021.109760 PMC 바로가기 [Article Type] Article
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence: Navigating the absence of a gold standard심한 급성 호흡기 증후군 코로나 바이러스 2 (SARS-COV-2) 혈청 유병률 : 금 표준의 부재를 탐색Research Article Published on 2021-09-232022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Abbott absence acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 assays Bayesian Blood donors can be used Canada Characteristics class conducted coronavirus COVID-19 pandemic credible interval CrI cross-sectional cross-sectional study diagnostic First wave gold gold standard healthy blood donor highest house IgG IgG antibody IgG ELISA immunoassay Latent Model nucleocapsid pandemic plasma sample plasma samples positive predicted Receptor binding domain reference standard Reference standards respiratory Result SARS-CoV-2 sensitivity Seroprevalence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike spike glycoprotein unique waned was tested while [DOI] 10.1371/journal.pone.0257743 PMC 바로가기 [Article Type] Research Article
Good Cholesterol Gone Bad? HDL and COVID-19Review Published on 2021-09-222022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 appear bind binding caused cholesterol class complex concentrations conditions coronavirus COVID-19 COVID-19 disease dependent on disease ENhance expression facilitate Good HDL high-density host cells increased risk Infection inverse correlation metabolism multiple study Other outbreak outcomes Particle receptor reported Respiratory disease resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle scavenger severity of COVID-19 shown Spike protein SR-B1 suppress suppressed target cells virus infection Wuhan, China [DOI] 10.3390/ijms221910182 PMC 바로가기 [Article Type] Review
A Role of Variance in Interferon Genes to Disease Severity in COVID-19 PatientsGenetics Published on 2021-09-172022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] ABO Affect Analysis Blood class consequence COVID-19 COVID-19 severity develop differential activity disease severity Factor group Host immune response individual interferon interferons involved magnitude marker novel coronavirus disease outcome Pathogens pathway Patient predict risk factor risk of infection role SARS-CoV-2 Scientific community severe COVID-19 severity shown Signaling the interferon type I interferon variance variant viral infection virus with COVID-19 [DOI] 10.3389/fgene.2021.709388 PMC 바로가기 [Article Type] Genetics