Recurrent SARS-CoV-2 Serology Testing and Pandemic Anxiety: A Study of Pediatric Healthcare Workers재발성 SARS-CoV-2 혈청 검사 및 유행성 불안: 소아 의료 종사자에 대한 연구Article Published on 2022-08-032022-09-12 Journal: International Journal of Environmental Research an [Category] SARS, 진단, [키워드] analyses Analysis antibody Antibody testing Anxiety asked baseline calculated change changes in clinically conducted COVID-19 decrease demographics Department Emergency examined female HCW HCWs healthcare worker indicated less Limited Logistic regression longitudinal cohort study male Nurse participant pediatric pediatrics performed positive test result Recurrent repeated repeated measure repeated measures reported routine SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody testing SARS-CoV-2 testing serology testing significantly higher Testing the disease worker [DOI] 10.3390/ijerph19159562 PMC 바로가기 [Article Type] Article
Neutralizing antibody activity against 21 SARS-CoV-2 variants in older adults vaccinated with BNT162b2BNT162b2 백신을 접종한 노인의 21개 SARS-CoV-2 변이체에 대한 항체 활성 중화Article Published on 2022-08-012022-09-11 Journal: Nature Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] Adults analysed antibody Antibody responses antigenic Antiviral B.1.1.529 B.1.351 B.1.617.2 Beta BNT162b2 Booster vaccine booster vaccines change clinically Cohort COVID-19 disease cross-protection Delta detectable disease domain dose Effectiveness elicit enzyme enzyme-linked immunosorbent assays examined group individual individuals median mitigate neutralization Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses neutralizing antibody titre neutralizing antibody titres of BNT162b2 Older Older adults omicron Pfizer-BioNTech pseudotype RBD responsible SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants sera serious COVID-19 Spike protein Spike proteins spike variants titre Vaccine vaccine dose variant variants wildtype [DOI] 10.1038/s41564-022-01163-3 PMC 바로가기 [Article Type] Article
Effect of Molnupiravir on Biomarkers, Respiratory Interventions, and Medical Services in COVID-19 : A Randomized, Placebo-Controlled Trial코로나19의 바이오마커, 호흡기 중재 및 의료 서비스에 대한 몰누피라비르의 효과 : 무작위, 위약 대조 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] 95% CI Analysis assigned baseline benefit C-reactive protein C-reactive protein (CRP Care change clinical benefit clinically Concentration COVID-19 CRP death discharge discharged double-blind Effect evaluated faster Hospitalization Hospitalized identify immunized improvement Improvements Inc Invasive mechanical ventilation less LLC median medical service medical services Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 molnupiravir Older oxygen oxygen saturation participant performed Phase 3 Placebo placebo-controlled placebo-treated participant placebo-treated participants potential clinical benefit progression randomization Randomized Randomly receiving reduction in Relative risk respiratory respiratory intervention respiratory interventions risk risk factor Risk factors risk reduction SARS-CoV-2 secondary service severe disease Sharp subsidiary therapy Trial [DOI] 10.7326/M22-0729 PMC 바로가기 [Article Type] Randomized Controlled Trial
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patientsAPOE는 ACE2와 상호작용하여 COVID-19 환자에서 SARS-CoV-2 세포 진입 및 염증을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] ACE2 addition Affect allele ApoE APOE4 Apolipoprotein Apolipoprotein e assays binding binding affinity cardiovascular diseases carrier carriers cells cellular entry chemokine cholesterol cholesterol metabolism clinically comparable Concentration COVID-19 infection COVID-19 patient COVID-19 patients disease severity docking domain elevated explain genetic risk factor Infection Inflammation Inflammatory factor inhibit inhibiting interact Interaction isoform Lipid mechanism metabolism Protein receptor reduce Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein serum serum concentrations spike Spike protein susceptibility the SARS-CoV-2 transmission electron microscopy viral entry viruses Zinc [DOI] 10.1038/s41392-022-01118-4 PMC 바로가기 [Article Type] Article
Pulmonary embolism severity index predicts adverse events in hospitalized COVID-19 patients: A retrospective observational study: PESI/sPESI and COVID-19 StudyResearch article Published on 2022-08-012022-10-05 Journal: Journal of cardiothoracic and vascular anesthesia [Category] 진단, 치료기술, [키워드] 95% confidence interval acute respiratory distress Admission adverse event adverse events age Analysis can be used cause clinically clinically suspected COVID-19 death evaluated hospital hospitalized COVID-19 hospitalized COVID-19 patient in-hospital mortality in-hospital mortality rate incidence independent risk factor intensive care invasive investigated measurement mechanical ventilation multivariate logistic regression noninvasive objective Odds ratio participant patients with COVID-19 polymerase chain positive predict Pulmonary embolism pulmonary embolism severity index (PESI) Respiratory distress syndrome Result retrospective scoring system sensitivity setting severity simplified PESI (sPESI) specificity study population syndrome the median Thromboembolic event venous Venous Thromboembolism women [DOI] 10.1053/j.jvca.2022.08.009 [Article Type] Research article
Clozapine and COVID-19 Vaccination: Effects on blood levels and leukocytes. An observational cohort studyObservational Study Published on 2022-08-012022-10-05 Journal: Acta psychiatrica Scandinavica [Category] 임상, [키워드] baseline Blood level C-reactive protein (CRP change changes in clinical implications clinically clozapine Concentration conducted COVID-19 COVID-19 vaccination COVID-19 vaccine Effect first dose had no haematological parameters help increase increase in increases in Inflammation leukocytes limit lymphocytopenia Mild moderate multicentre Observational cohort study occurred outcome Patient patients plasma plasma concentration Prevent Psychoeducation Safe Safety second dose second vaccination secondary significantly Symptom therapeutic vaccination WBC were measured White blood cell [DOI] 10.1111/acps.13428 PMC 바로가기 [Article Type] Observational Study
Nanoformulated Remdesivir with Extremely Low Content of Poly(2-oxazoline)-Based Stabilizer for Aerosol Treatment of COVID-19COVID-19의 에어로졸 치료를 위한 폴리(2-옥사졸린) 기반 안정제 함량이 매우 낮은 나노제형 렘데시비르Article Published on 2022-08-012022-09-11 Journal: Macromolecular bioscience [Category] COVID19(2023년), SARS, 치료제, [키워드] 2-Oxazoline aerosol antiviral efficacy antiviral therapy approved can be used cause Characteristics clinically Concentration content COVID-19 Diseases dose global pandemic IMPROVE Infection nanocrystal outcome pandemic physician poly(2-oxazoline) Polymer reagent Remdesivir SARS-CoV2 Stabilizer Suspension target the disease therapeutic treat treatment for COVID-19 virus [DOI] 10.1002/mabi.202200056 PMC 바로가기 [Article Type] Article
Autoantibodies in COVID-19 correlate with antiviral humoral responses and distinct immune signaturesCOVID-19의 자가항체는 항바이러스 체액 반응 및 뚜렷한 면역 신호와 상관관계가 있습니다Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] acute COVID-19 acute disease acute SARS-CoV-2 infection alteration antibody Antibody titer Antibody titers antineutrophil cytoplasmic antibodies antinuclear antibodies Antiviral association autoantibodies autoantibody Autoimmune autoimmune pathology B-cell breadth clinically Cohort Comorbidities comparable controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cross-reactive cytoplasmic demonstrated detect disease disease course exhibited feature healthy controls humoral immune response Humoral response humoral responses immune immune responses immune signature Immunity immunofluorescence assay implication indirect immunofluorescence individual Infection Inflammatory occur other coronavirus other coronaviruses Paired analysis Patient patients performed Prevalence proteomics SARS-CoV-2 screened serological serum severe COVID-19 severity of COVID-19 subgroup of patient trajectory vaccinated individuals VirScan [DOI] 10.1111/all.15302 PMC 바로가기 [Article Type] Article
Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodiesArticle Published on 2022-08-012022-11-15 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] affected analyzed auto-antibody autoantibodies benefit Biomarker circulating Clinical outcome clinical parameter clinically Cohort COVID-19 COVID-19 patient Critical Critically ill critically ill patients defined detectable disease Effect ELISA evaluated FIVE hospital Hospital admission hospitalized COVID-19 patient identification IFN-α interferon male Neutralization assay Neutralizing Neutralizing activity Oxygen requirement Patient post-symptom onset Prevalence probability of survival Rapid reduced SARS-CoV-2 SARS-CoV-2 antibody sera severe COVID-19 specificity subsequent survival Therapeutic plasma exchange Therapies TPE Type type I interferon undetectable uninfected control WHO [DOI] 10.1007/s10875-022-01252-2 PMC 바로가기
The ongoing effects of the COVID-19 pandemic on perceived physical activity, physical function and mood of older adults in the U.K: A follow-up study (March 2020-June 2021)COVID-19 대유행이 영국 노인의 인지된 신체 활동, 신체 기능 및 기분에 미치는 지속적인 영향: 후속 연구(2020년 3월-2021년 6월)Observational Study Published on 2022-08-012022-09-11 Journal: Experimental gerontology [Category] 변종, 임상, [키워드] Bayesian analysis calculation clinically conducted COVID-19 COVID-19 pandemic decrease Effect effort female Follow-up follow-up study impacted intensity interval knowledge male margin MONITOR mood observational study Older older adult Older adults participant pattern physical physical activity physical activity level physical activity levels Probability reflected Spread United Kingdom variants wild-type virus Wuhan Wuhan, China [DOI] 10.1016/j.exger.2022.111838 PMC 바로가기 [Article Type] Observational Study