Improved Analysis of COVID-19 Influenced Pneumonia from the Chest X-Rays Using Fine-Tuned Residual Networks미세 조정된 잔류 네트워크를 사용하여 흉부 X선에서 코로나19 영향 폐렴에 대한 향상된 분석Article Published on 2022-06-162022-09-11 Journal: Computational Intelligence and Neuroscience [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy addressed Analysis Antigen approach Chest chest X-ray Chest X-ray images chest X-rays CNN contagious Convolutional neural network COVID COVID-19 Critical CXR dataset demonstrated Diagnosis effective Epidemic examined Genetic highest IMPROVE Improved indicated individual instance network occurred outcome past positive positive individuals Prevent reached reduction in cases remained residual resulting RT-PCR screened time-consuming virus weakness X-ray [DOI] 10.1155/2022/9414567 PMC 바로가기 [Article Type] Article
SperoPredictor: An Integrated Machine Learning and Molecular Docking-Based Drug Repurposing Framework With Use Case of COVID-19SPEROPDICTOR : COVID-19의 사용 사례와 함께 통합 된 기계 학습 및 분자 도킹 기반 약물 재검사 프레임 워크Article Published on 2022-06-162022-08-31 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] Accuracy association candidate clinically collected contagious contagious disease coronavirus costly COVID-19 data analytics database databases dataset de novo death disease drug drug candidate Drug discovery Drug repurposing effective effort Extensive FDA approval FDA-approved drug FDA-approved drugs feature Features followed by forest framework generic drug Gradient Host host proteomes human host indicated inefficient machine learning molecular docking pandemic Pandemics platform predicted proteome Random forest rapid response reduce repurposing Research resulting SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 Spread spread of COVID-19 systematic review Threats Traditional tree trees variant [DOI] 10.3389/fpubh.2022.902123 PMC 바로가기 [Article Type] Article
The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL ProteasePolygonum cuspidatum 뿌리 및 뿌리 줄기 추출물은 S-단백질 및 3CL 프로테아제의 억제를 통해 SARS-CoV-2 야생형 및 오미크론 의사형 바이러스의 진입을 차단합니다Article Published on 2022-06-132022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL ACE2 angiotensin Angiotensin-converting enzyme Anti-viral block blocked caused Chinese Compound contagious COVID-19 develop disease effective Efficacy Ethanol Extract fibroblast fibroblasts gallic acid herbal medicine Infection inhibit inhibition Interaction omicron Omicron variant pandemic pharmacological treatment phytochemical Polygoni Cuspidati Rhizoma et Radix Polygonum Protease activity Pseudotyped virus pseudovirus pseudovirus entry Radix receptor responsible resulting rhizome root S-protein SARS-CoV-2 SARS-CoV-2 pseudotyped virus SARS-CoV-2 virus shown Spike protein tested the SARS-CoV-2 the SARS-CoV-2 virus the spike protein Traditional Chinese medicine Treatment Vaccines water wild-type zebrafish zebrafish larvae. [DOI] 10.3390/molecules27123806 PMC 바로가기 [Article Type] Article
Artificial intelligence against the first wave of COVID-19: evidence from ChinaCOVID-19의 첫 번째 물결에 맞서는 인공 지능: 중국의 증거Article Published on 2022-06-102022-09-11 Journal: BMC health services research [Category] COVID19(2023년), SARS, 치료기술, [키워드] added artificial artificial intelligence Case fatality rate China confirmed cases contagious control variable control variables COVID-19 COVID-19 pandemic cumulative dependent variable dependent variables detect Diagnosis dimension disease Effectiveness evaluate Evidence Evolution Fatality rate feature First wave first-wave high risk Infection prevention interaction term Local mechanism OLS pandemic Poisson powerful tool prevention Prevention and control severe cases significant effect suggested the disease the epidemic Treatment variety widespread [DOI] 10.1186/s12913-022-08146-4 PMC 바로가기 [Article Type] Article
Mutation induced infection waves in diseases like COVID-19COVID-19와 같은 질병에서 돌연변이 유발 감염 파동Article Published on 2022-06-102022-09-11 Journal: Scientific Reports [Category] Coronavirus, 변종, 치료법, [키워드] caused competing contagious COVID-19 COVID-19 disease death decrease disease Diseases Evolution example Giant grain growth increasingly induce Infection Infectious disease Infectious diseases majority measure Mutation mutations occur outcomes positive feedback positive feedback loop predict reduce risk statistical statistical mechanics Strains tested vaccination wave train wave trains [DOI] 10.1038/s41598-022-13137-w PMC 바로가기 [Article Type] Article
The Prevalence and Pathophysiology of Chemical Sense Disorder Caused by the Novel Coronavirus신종 코로나바이러스로 인한 화학적 감각 장애의 유병률 및 병태생리학Review Published on 2022-06-062022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] ACE-2 acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme Angiotensin-converting enzyme 2 receptor angiotensin-converting enzyme 2 receptor (ACE-2) article Chemical Chemical Sense chemical senses contagious coronavirus 2 coronavirus disease coronavirus variants COVID-19 described disorder dysfunction Effect enzyme global public health management mechanism morbidity novel Novel coronavirus novel coronavirus disease novel coronavirus disease (COVID-19) olfactory olfactory dysfunction pathogenic pathophysiologic pathophysiology Patient Prevalence receptor reported respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sense severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effects taste dysfunction viral infection viral infections [DOI] 10.3389/fpubh.2022.839182 PMC 바로가기 [Article Type] Review
Molecular diagnostics of SARS-CoV-2: Findings of an international surveySARS-CoV-2의 분자 진단: 국제 조사 결과Article Published on 2022-06-012022-09-11 Journal: Clinica chimica acta; international journal of cli [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] array Chain Reaction Chemistry clinical clinical chemistry Committee concerning Contact tracing contagious Containment country COVID COVID 19 COVID-19 pandemic Diagnosis diagnostic Diagnostic method diagnostic testing diagnostics Federation finding Genetic identify individual initiated International Laboratory laboratory procedures majority Medicine molecular molecular diagnostics NAAT participated Participation performed polymerase chain polymerase chain reaction processing Quality assurance quarantine question raise reported Reporting response reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 testing Sequencing Standardization survey the disease transcriptase Transmission variant variants [DOI] 10.1016/j.cca.2022.04.007 PMC 바로가기 [Article Type] Article
Structure-based virtual screening, in silico docking, ADME properties prediction and molecular dynamics studies for the identification of potential inhibitors against SARS-CoV-2 M proSARS-CoV-2 M pro에 대한 잠재적 억제제 식별을 위한 구조 기반 가상 스크리닝, 인실리코 도킹, ADME 특성 예측 및 분자 역학 연구Article Published on 2022-06-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] ADME affected Amino acid amino acid residue Asinex library ASN binding CADD carried caused complex Compound compounds computer Computer aided drug design conformational contagious COVID-19 COVID-19 patients docked docking drug drug candidate drug design druggability enzyme evaluated GLU Health Organization hydrogen Hydrogen bond hydrogen bond interactions identify in silico include Infection inhibitor interactions knocking down Ligand M pro maturation molecular molecular dynamics Molecular dynamics simulation Mortality Mpro protein Mutation optimization pandemic participated pharmacological PHE Protein protein-ligand protein-ligand interaction protein-ligand interactions Replication responsible RMSD RMSF SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 Mpro SARS-CoV-2 Mpro protein Schrodinger software stability strain therapeutic option these compound these compounds TRP Virtual screening virulent was used World Health Organization [DOI] 10.1007/s11030-021-10298-0 PMC 바로가기 [Article Type] Article
Design and various in silico studies of the novel curcumin derivatives as potential candidates against COVID-19 -associated main enzymesCOVID-19 관련 주요 효소에 대한 잠재적 후보로서 새로운 커큐민 유도체의 설계 및 다양한 in silico 연구Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro acute respiratory syndrome ADME Analysis Anti-inflammatory antioxidant Antiviral antiviral drug antiviral drugs Area binding binding score candidate caused Combination contagious contagious disease coronavirus coronavirus disease Coronaviruses COVID-19 Curcumin derivative disease docking drug drug design drugs Effectiveness enzyme Enzymes expected in silico inhibitor inhibitors Ligand MD simulation MD simulations Mechanics MM-PBSA molecular molecular docking studies Molecular dynamic Molecular mechanics Novel coronavirus novel coronavirus disease Nsp15 Nsp7 patients performed pharmacokinetic PLPro Protein protein complex residue Safe SARS-CoV-2 SARS-CoV-2 virus Severe acute respiratory syndrome shown Simulation spike surface surface area the SARS-CoV-2 virus therapeutic Toxicity was determined [DOI] 10.1016/j.compbiolchem.2022.107657 PMC 바로가기 [Article Type] Article
Quantitative analysis of favipiravir and hydroxychloroquine as FDA-approved drugs for treatment of COVID-19 using synchronous spectrofluorimetry: application to pharmaceutical formulations and biological fluids동시 분광형광법을 사용한 COVID-19 치료를 위한 FDA 승인 약물인 favipiravir 및 hydroxychloroquine의 정량 분석: 제약 제제 및 생물학적 유체에 적용Article Published on 2022-06-012022-09-11 Journal: Luminescence : the journal of biological and chemi [Category] COVID19(2023년), SARS, 치료기술, [키워드] Acetate acute respiratory syndrome Analysis applied approach biological fluid biological fluids buffer cause caused condition contagious coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 country COVID-19 Detection limit diluent drug Drug administration Ethanol exhibited Favipiravir FDA-approved drug fluorescence intensity food harmonization Healthcare systems human plasma sample human plasma samples Hydroxychloroquine identify information Interference International Conference investigated limit limits medications Pharmaceutical Preparation pharmaceutical preparations quantitation SARS-CoV-2 sensitivity Severe acute respiratory syndrome synchronous synchronous fluorimetry. Treatment United State United States United States Food and Drug Administration viral infection were measured [DOI] 10.1002/bio.4240 PMC 바로가기 [Article Type] Article