miR-142-5p Disrupts Neuronal Morphogenesis Underlying Porcine Hemagglutinating Encephalomyelitis Virus Infection by Targeting Ulk1Microbiology Published on 2017-05-032022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] Coronavirus, MERS, [키워드] cause caused Central nervous system CNS Control cortical demonstrated dendritic disease disrupting dysfunction Encephalomyelitis functional Host increased survival Infection inhibitor Injury mice microenvironment microRNA miR-142-5p morphogenesis mRNA neurodegeneration neurodegenerative neurological Neuron neuronal neuronal morphogenesis neurotropic virus PHE phenotype porcine hemagglutinating encephalomyelitis virus provided regulate Relieving significantly spatiotemporal targeting Ulk1 viral replication virus [DOI] 10.3389/fcimb.2017.00155 PMC 바로가기 [Article Type] Microbiology
Disrupting the cortical actin cytoskeleton points to two distinct mechanisms of yeast [ PSI + ] prion formation피질의 액틴 세포골격을 교란하는 것은 효모 [PSI + ] 프리온 형성의 두 가지 뚜렷한 메커니즘을 나타냅니다.Research Article Published on 2017-04-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogate abrogated Actin affected Affinity purification aggregate aggregates aggregation Analysis antioxidant component composed conditions cortical Deletion disease disrupt examined form forms fragmentation Frequency fungal identify implicated increase infectious agent infectious agents insoluble protein mass spectrometry mechanism misfolded protein misfolded proteins molecular MOST mutant mutants neurodegenerative occur overexpression oxidative oxidative damage oxidative stress oxidized Prevent Previous studies previous study prion Probability Protein Protein misfolding Proteins PSI reduced required thought transition translation Trigger undergo yeast yeast cell yeast cells [DOI] 10.1371/journal.pgen.1006708 PMC 바로가기 [Article Type] Research Article
Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes인간 희귀 뼈 질환의 세 가지 개 모델의 분자 특성: 카페, 반 덴 엔데 굽타 및 레인 증후군Research Article Published on 2016-05-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affected approaches associations bone candidate gene canine Cell characterization characterized children clinical feature Clinical features complementary condition conditions cortical craniomandibular osteopathy developmental developmental disorder developmental disorders disease disorders enhancer experiments expressed facilitated FAM20C feature Genes genetic cause genome-wide association Glucose homeostasis Hospital admission Hospital admissions Human hyperostosis identity include infantile cortical hyperostosis Lineage Macrophage mechanism missense variant Model molecular molecular mechanism molecular mechanisms Mortality Mutation next generation sequencing Pathogenesis pathogenic variant pathology pediatric performed phosphate provide rare disease rare diseases Research SCARF2 Sequencing skeletal SLC37A2 syndrome therapeutic therapeutic trials Therapeutics therapy tissues Treatment trials variant [DOI] 10.1371/journal.pgen.1006037 PMC 바로가기 [Article Type] Research Article
Myosins 1 and 6, myosin light chain kinase, actin and microtubules cooperate during antibody-mediated internalisation and trafficking of membrane-expressed viral antigens in feline infectious peritonitis virus infected monocytesResearch Published on 2014-02-122022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] accumulated Actin antibodies Antigen association binding can be used cell lysis complexes coronavirus cortical cytoskeletal experiment Express filaments found Infected infectious inhibiting Intracellular investigated kinase monocyte myosin overcome pathway plasma membranes Protein subsequent Transport transported Treatment Vesicle Viral antigen Viral protein virus [DOI] 10.1186/1297-9716-45-17 PMC 바로가기 [Article Type] Research