SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans
Research Article
[키워드] acute respiratory syndrome
Analysis
Antiviral
bat
bat coronaviruses
cofactor
Comprehensive
conserved
coronavirus
coronavirus disease
COVID-19
CpG
CpG suppression
defined
dinucleotide
effective
effector
Efficiency
Environment
evaluated
Evidence
Evolution
experiment
expressed
expression
expression levels
finger
genomic
greater
Host
Human
human coronaviruses
human lung cells
humans
I, II
IFN
IFN-α
IFN-γ
IFNs
immune
in viral
inhibit SARS-CoV-2
inhibited
innate response
interferon
isoform
KHNYN
lowest
orthologue
orthologues
pandemic
pathogen
promote
Protein
recent
reduced
restrict
Restricted
RNA sequences
SARS-CoV-2
SARS-CoV-2 replication
SARS-CoV-2 RNA
sequence
significantly
suppressed
target
the SARS-CoV-2 genome
therapy
Treatment
TRIM25
Type
viral pathogen
ZAP
Zinc
zoonosis
[DOI] 10.1128/mBio.01930-20 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/mBio.01930-20 PMC 바로가기 [Article Type] Research Article