cross-reactivity – Page 8 – Communicable Diseases Research

Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine

BNT162b2 SARS-CoV-2 RNA 백신에 대한 항원 특이적 반응의 단일 세포 프로파일링

Article

Published on 2022-06-162022-09-11
Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 진단,

Fcγ-Receptor-Based Enzyme-Linked Immunosorbent Assays for Sensitive, Specific, and Persistent Detection of Anti-SARS-CoV-2 Nucleocapsid Protein IgG Antibodies in Human Sera

인간 혈청에서 항-SARS-CoV-2 뉴클레오캡시드 단백질 IgG 항체의 민감하고, 특이적이고, 지속적인 검출을 위한 Fcγ-수용체 기반 효소 연결 면역흡착 분석법

Article

Published on 2022-06-152022-09-11
Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,

[키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African analytical sensitivity anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody antibody antibody waning Antigen antigen-antibody complexes Asia binding complexes Concentration convalescence convalescent phase coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cross-reactivity detection diagnostic diagnostic sensitivities dilutions ELISA ELISAs enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epidemiological studies Epidemiological study Europe FcγR Human IgG IgG antibody Immune complexes immunoassay immunofluorescence immunoglobulins immunological indirect immunofluorescence Infection Infectious disease Laboratory laboratory methods and tools longitudinal samples mandatory morbidity morbidity and mortality mortality rates nucleocapsid protein Pathogens persistent platform Population Postinfection Prevalence prozone receptor Region respiratory SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibody sensitive sensitivity serological test Serological tests serum serum sample serum samples severe acute respiratory syndrome Coronavirus significantly significantly higher solution South America Specific Specificities specificity titer Vaccine validation Viral Viral diseases was performed while
[DOI] 10.1128/jcm.00075-22 PMC 바로가기 [Article Type] Article

Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles

널리 알려진 교차 반응성 SARS-CoV-2 CD4 T 세포 에피토프는 인간 코로나바이러스 전반에 걸쳐 고도로 보존되어 있으며 일반적인 HLA 대립유전자에 의해 제시됩니다

Article

Published on 2022-06-142022-09-12
Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] Affect animal coronavirus binding CD4 CD4 T cell CD4 T cells common-cold conserved Contact convalescent COVID-19 CP: Immunology CP: Microbiology cross-reactive cross-reactivity Donor donors driven by epitope explained fusion peptide Heterologous heterologous immunity highlight HLA allele homology human coronavirus human populations Infection major histocompatibility complex memory response MHC class mRNA vaccine overlapping preference Protein proximal raise recipients residue SARS-CoV-2 SARS-CoV-2 sequence seasonal coronavirus spike fusion peptide proximal region. Substitution T cell T cell epitope T cell receptor T cell receptor repertoire T cell response TCR TCR sequencing TCRs uninfected
[DOI] 10.1016/j.celrep.2022.110952 PMC 바로가기 [Article Type] Article

Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19

COVID-19에 대한 비강내 예방으로서 광범위한 변이 활성을 갖는 계란 유래 항-SARS-CoV-2 면역글로불린 Y(IgY)

Clinical Trial

Published on 2022-06-012022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단,

[키워드] 2019 novel coronavirus 2019-nCoV activity Administered Against Alpha anti-SARS-CoV-2 Antiviral approval approvals B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta binding capture chicken immunoglobulin clinical clinical trial clinical trial body Clinical use contagiousness Convalescent patients COVID-19 cross-reactivity Delta demonstrated develop Diseases distribution double-blind effective Emergency use authorization enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Evidence evidence of greater healthy human tissue human tissues IgY Immunity immunized Immunoglobulin immunoglobulin Y index Infectious diseases intranasal intranasally multiple dose multiple doses nasal drop nasal drops nasal mucosa neutralization titer no evidence of Novel coronavirus omicron Phase 1 phase 1 study Placebo placebo-controlled Prevalence Prophylaxis raised Randomized RATs RBD Receptor-binding domain reduce reduced risk Safe safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral sensitivity sera Spike protein the receptor-binding domain the SARS-CoV-2 Tolerability Transmission Trial Vaccine Vaccine hesitancy variants variants of concern variety Viral virus
[DOI] 10.3389/fimmu.2022.899617 PMC 바로가기 [Article Type] Clinical Trial

IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes

뚜렷한 계절성 코로나바이러스-보존 SARS-CoV-2 스파이크 하위 도메인을 표적으로 하는 IgG는 차별적인 COVID-19 질병 결과와 상관관계가 있습니다

Article

Published on 2022-05-312022-09-11
Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제,

[키워드] Activation ADE amplification anti-Spike IgG anti-spike IgG levels anti-spike IgG response Anti-spike IgG responses antibody antibody-mediated effector responses Betacoronavirus betacoronaviruses caused conserved convalescent individual coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 severity CoVs CP: Immunology CP: Microbiology cross-reactivity Deleterious disease disease severity Early detection epitope Epitopes Fc-gamma receptor activation FcγR fusion protein fusion protein region greater heptad repeat heptad repeat region human betacoronavirus human betacoronavirus. humoral IgG IgG responses immunodominant epitope immunology lowest memory response Microbiology observé OC43 offer outcome predict profile Protective recall receptor responses SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS1 seasonal coronaviruses severe COVID-19 patient severe COVID-19 patients severe disease significantly Spectrum Spike protein the SARS-CoV-2 virus β-CoVs
[DOI] 10.1016/j.celrep.2022.110904 PMC 바로가기 [Article Type] Article

Vaccination with BNT162b2 and ChAdOx1 nCoV-19 Induces Cross-Reactive Anti-RBD IgG against SARS-CoV-2 Variants including Omicron

BNT162b2 및 ChAdOx1 nCoV-19 백신 접종은 Omicron을 포함한 SARS-CoV-2 변이체에 대한 교차 반응성 항-RBD IgG를 유도합니다

Article

Published on 2022-05-282022-09-11
Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법,

[키워드] adaptive Adaptive immunity age Alpha Alpha variant anti-RBD BNT162b2 booster vaccinations Breakthrough infection breakthrough infections caused ChAdOx1 ChAdOx1 nCoV-19 Cohort contribute Course COVID-19 cross-reactive cross-reactive antibodies cross-reactivity Delta delta variant domain ELISA explain Gamma health-care IgG IgG ELISA IgG level IgG levels Immunity independent independent of individual Infection infection rate lethality magnitude morbidity nucleocapsid nucleocapsid IgG omicron Omicron variants RBD RBD IgG reactivity Receptor-binding domain Receptor-binding domain (RBD) recipient SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variants sera Sex significant increase significantly higher significantly lower Spike protein Spread tested the spike protein university vaccination vaccination rate Vaccine variants variants of concern Vienna VoC VOCs was increased while
[DOI] 10.3390/v14061181 PMC 바로가기 [Article Type] Article

CMV seropositivity is a potential novel risk factor for severe COVID-19 in non-geriatric patients

CMV 혈청 양성은 비노인 환자에서 심각한 COVID-19에 대한 잠재적인 새로운 위험 요소입니다

Article

Published on 2022-05-252022-09-11
Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] absence advanced age affected Analysis Biomarker CMV co-morbidities Cohort cohorts Comorbidities confirmation COVID-19 Critical cross-reactivity cytomegalovirus deaths detectable disease disease severity distribution finding herpes simplex herpes simplex virus higher risk Hypothesis ICU IgG individual individuals intensive care investigated Mild Mild disease moderate morbidities occur older patients Patient performed prediction Prevalence representing risk factor SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serology Seropositivity serostatus severe COVID-19 severe disease statistical Support T cell T cells were used with mild disease
[DOI] 10.1371/journal.pone.0268530 PMC 바로가기 [Article Type] Article

Antigenic Cross-Reactivity Between SARS-CoV-2 S1-RBD and Its Receptor ACE2

SARS-CoV-2 S1-RBD와 수용체 ACE2 간의 항원 교차 반응성

Article

Published on 2022-05-042022-09-12
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] ACE2 acute respiratory syndrome addition amino acid residue Analysis analyzed angiotensin converting enzyme 2 angiotensin-converting enzyme 2 anti-ACE2 antibody antibody Antibody binding antigenic autoantibody bind binding Control coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Critical cross-react cross-reactivity denatured disease severity docking domain enzyme epitope higher affinity human cell increase in indicated mAb measurement mechanism mice molecular molecular mimicry monoclonal antibody overlapping patients with COVID-19 peptide positive correlation protein-protein interaction receptor receptor ACE2 recognize responsible SARS-CoV-2 SARS-COV-2 infection sera Serum level significantly significantly higher the binding affinity the S1 subunit the spike protein transmission electron microscopy virus western blotting
[DOI] 10.3389/fimmu.2022.868724 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Cross-Reactivity in Prepandemic Serum from Rural Malaria-Infected Persons, Cambodia

캄보디아 농촌 말라리아 감염자의 전염병 전 혈청에서 SARS-CoV-2 교차 반응성

Article

Published on 2022-05-012022-09-12
Journal: Emerging Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 말라리아, 진단,

Seroreactivity of the Severe Acute Respiratory Syndrome Coronavirus 2 Recombinant S Protein, Receptor-Binding Domain, and Its Receptor-Binding Motif in COVID-19 Patients and Their Cross-Reactivity With Pre-COVID-19 Samples From Malaria-Endemic Areas

COVID-19 환자에서 중증 급성 호흡기 증후군 코로나바이러스 2 재조합 S 단백질, 수용체 결합 도메인 및 이의 수용체 결합 모티브의 혈청반응성과 말라리아 발병 지역의 코로나19 이전 샘플과의 교차 반응성

Article

Published on 2022-04-272022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 말라리아, 진단, 치료기술,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition age anti-S antibody antibody Antibody Response Antibody responses Antigen antigens Area Asthma blood sample Blood samples Community Comorbidities conducted coronavirus coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 samples cross-reactive antibody cross-reactivity determine diabete diabetes disease Donor ELISA full-length Gender hospital IgG antibodies IgG antibody individual malaria malaria endemic-area participant Patient Plasmodium falciparum Plasmodium falciparum infection Pre-COVID-19 samples Protein RBD RBM Receptor-binding domain receptor-binding motif Recognition Recombinant S regions respiratory response responses S protein Sample SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 S SARS-CoV-2 S protein sera seroreactivity severe acute respiratory syndrome Coronavirus Study participants tested the receptor-binding domain the SARS-CoV-2 Treatment triggered weakened West while
[DOI] 10.3389/fimmu.2022.856033 PMC 바로가기 [Article Type] Article