Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study영국 런던의 신종 SARS-CoV-2 B.1.1.7 계통의 게놈 특성 및 임상 효과: 전체 게놈 시퀀싱 및 병원 기반 코호트 연구Article Published on 2021-09-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] SARS, 변종, 치료기술, [키워드] adjusted age analysed Analysis association B.1.1.7 B.1.1.7 variant Characteristics Clinical effect Clinical severity Cohort cohort study collected college Comorbidities Council Cycle threshold value death defined emergence Engineering epitope Epitopes Ethnicity Evidence evidence of genomic genomic read hospital hospitalised identify Immunocompromised patient Immunocompromised patients inclusion criteria Infection Lineage London mass vaccination monoclonal antibodies Mutation mutations NHS NIHR no evidence of Ordinal Scale Patient patients PCR PCR cycle Poisson regression model Poisson regression models positive Positive test Prevalence raise Remdesivir SARS-CoV-2 SARS-CoV-2 B.1.1.7 Science sequenced Sequencing severe disease Sex specific mutation specific mutations Spike protein Symptom the spike protein the WHO threshold value Transmissibility Trust university vaccination variant variants Viral load Virological virus load VoC WHO ordinal scale whole-genome sequencing [DOI] 10.1016/S1473-3099(21)00170-5 PMC 바로가기 [Article Type] Article
Analysis of SARS-CoV-2 reverse transcription-quantitative polymerase chain reaction cycle threshold values vis-à-vis anti-SARS-CoV-2 antibodies from a high incidence regionSARS-CoV-2 역전사-정량적 중합효소연쇄반응 주기 역치, 고발생 지역의 항 SARS-CoV-2 항체에 대한 분석Article Published on 2021-09-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 유전자 메커니즘, [키워드] Admission anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody Response antibody status association Chain Reaction Clinical course comparability contribute correlated Course COVID-19 COVID-19 patients Ct value Ct values cycle threshold Cycle threshold value diagnostic Elimination examined immune response incidence independent independent of Inpatients onset of symptom onset of symptoms outcome polymerase chain polymerase chain reaction positive patient positively correlated Prognostic value qPCR quantitative polymerase chain reaction quantitative value quantitative values reverse transcription RT-qPCR SARS-CoV-2 significant difference significant differences significantly higher survivor target gene Target genes the antibody response the disease therapeutic Viral load virus [DOI] 10.1016/j.ijid.2021.07.014 PMC 바로가기 [Article Type] Article
Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individualsSARS-CoV-2 게놈 및 COVID-19 개인의 서브게놈 단편의 올리고뉴클레오티드 캡처 시퀀싱Research Article Published on 2021-08-252022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] allelic approach capture capture sequencing cause CDC clinical sample clinical samples Complete coronavirus disease Coronavirus disease 2019 COVID-19 Cycle threshold value effective facilitate Frequency full-length genome functional generate Genome genomic hybridization individual infected patients junction methodology mixture offer oligonucleotide oligonucleotide probe Open reading frame ORF1ab gene ORFs Patient qPCR assay Region representing RNA SARS-CoV-2 sequence Sequencing subpopulation suggested the SARS-CoV-2 genome transcriptional activity Transcriptome Viral load viral RNA species viral RNA specy [DOI] 10.1371/journal.pone.0244468 PMC 바로가기 [Article Type] Research Article
Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies급성 SARS-COV-2 감염의 바이러스 역학 및 진단 및 공중 보건 전략에 대한 적용Research Article Published on 2021-07-122022-09-10 Journal: PLoS Biology [Category] SARS, 진단, 치료기술, [키워드] 95% CI acute infections acute SARS-CoV-2 infection asymptomatic individual Asymptomatic individuals average certainty characterized clearance clinical care Concentration credible interval Cycle threshold value Decline diagnostic early stage early stages effective sensitivity followed by help identify IMPROVE individual Infection infectious initial Intervention mathematical mathematical model measure PCR testing peaked positive PCR test public health Quantitative remained reverse transcription PCR SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 viral stages Surveillance symptomatic individual symptomatic individuals Symptoms test turnaround time trajectory Viral viral clearance viral dynamics viral proliferation Viral RNA Viral RNA shedding [DOI] 10.1371/journal.pbio.3001333 PMC 바로가기 [Article Type] Research Article
Dexamethasone may improve severe COVID-19 via ameliorating endothelial injury and inflammation: A preliminary pilot study덱사메타손은 내피 손상 및 염증을 개선함으로써 심각한 코비드 -19를 향상시킬 수 있습니다 : 예비 파일럿 연구Comparative Study Published on 2021-07-022022-09-10 Journal: PLoS ONE [Category] SARS, 바이오마커, [키워드] analyzed angiopoietin baseline benefit Biomarker Biomarkers both groups C-reactive protein change characterized clinical parameter Clinical parameters clinically Concentration controls coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patients Cycle threshold value decrease decreases Dexamethasone disease severity endocan endothelial injury evaluate exhibited group High-flow nasal cannula ICAM-1 immunological profile IMPROVE increase in Inflammation Injury intercellular intercellular adhesion molecule interleukin-6 less lung lung epithelial mechanical ventilation nasal nasal cannula oxygen Patient pilot study plasma biomarker Protein provide radiologic receive receptor relative severe COVID-19 significant decrease significantly significantly higher supplemental oxygen syndecan Viral viral clearance von Willebrand factor [DOI] 10.1371/journal.pone.0254167 PMC 바로가기 [Article Type] Comparative Study
Detection of SARS-CoV-2 in Fecal Samples From Patients With Asymptomatic and Mild COVID-19 in Korea한국의 무증상 및 경증 COVID-19 환자의 대변 샘플에서 SARS-CoV-2 검출Article Published on 2021-07-012022-09-11 Journal: Clinical gastroenterology and hepatology : the off [Category] SARS, 치료기술, [키워드] abdominal pain Analysis appear Asymptomatic Chain Reaction characterized collected collected data coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis Cycle threshold value detect detection diarrhea disease dyspepsia fecal Fecal sample fecal samples feces Fever followed by Gastrointestinal Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract investigated manifestation median age median interval men Mild mild symptoms nasopharyngeal nausea oropharyngeal swabs Patient patients patients with asymptomatic patients with COVID-19 Pneumonia polymerase chain polymerase chain reaction quarantine respiratory respiratory shedding respiratory specimen respiratory specimens respiratory symptoms RNA route Sample SARS-CoV-2 Severe acute respiratory syndrome shedding specimen specimens sputum Stool test negative transmission of SARS-CoV-2 upper respiratory Viral load virus virus RNA [DOI] 10.1016/j.cgh.2020.06.005 PMC 바로가기 [Article Type] Article
Evaluation of sample treatments in a safe and straightforward procedure for the detection of SARS-CoV-2 in saliva타액 내 SARS-CoV-2 검출을 위한 안전하고 간단한 절차로 시료 처리 평가Article Published on 2021-07-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] Analysis assay Chain Reaction contribute COVID-19 Cycle threshold value detect dithiothreitol ethylenediaminetetraacetic acid evaluate evaluated flexible Heating highlight individual infected individual infected individuals isothermal amplification LAMP limit of detection Loop-mediated isothermal amplification Nasopharyngeal swab Patient phosphate phosphate buffer point-of-care polymerase chain polymerase chain reaction proteinase Proteinase K ranged reverse-transcriptase polymerase chain reaction RT-LAMP Safe Saliva saliva sample saliva samples SARS-CoV-2 sensitivity the disease Treatment viral particle Viral particles [DOI] 10.1016/j.ijid.2021.05.053 PMC 바로가기 [Article Type] Article
Diagnostic accuracy of Panbio rapid antigen tests on oropharyngeal swabs for detection of SARS-CoV-2SARS-COV-2의 검출을위한 인두 면봉에 대한 Panbio 신속 항원 검사의 진단 정확도Clinical Trial Published on 2021-06-242022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] (Abbott Abbott Ag-RDT Ag-RDTs clinical sensitivity clinical specificity conducted COVID-19 COVID-19 pandemic criteria cut-off Cycle threshold value Cycle threshold values diagnostic Diagnostic accuracy diagnostic tests enrolled False positive in some incidence individuals Infectious virus nasopharyngeal nasopharyngeal swabs NPs offer Oropharyngeal oropharyngeal swab oropharyngeal swabs Outpatient PanBio pandemic patients positive Prospective Study qPCR quantitative PCR Rapid rapid antigen test Rapid diagnostic test Rapid test RDT RDTs required Result RT-qPCR RT-qPCR test SARS-CoV-2 SARS-CoV-2 genome sensitivity specificity specimen Swab Switzerland symptomatic individuals Test the WHO was obtained [DOI] 10.1371/journal.pone.0253321 PMC 바로가기 [Article Type] Clinical Trial
Comparative performance and cycle threshold values of 10 nucleic acid amplification tests for SARS-CoV-2 on clinical samplesResearch Article Published on 2021-06-232022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] Accuracy amplifying approved assays Clinical practice clinical sample clinical settings Clinical use Comparative cycle threshold Cycle threshold value Diagnosis diagnostic difference Diseases E-gene eight Emergency use authorization false-positive result Genetic gold standard include increasingly Japan marker NAAT nine nucleic acid amplification positive result positive sample ranged reagent reagents receiving Research Result SARS-CoV-2 sensitivity Significant specificity while [DOI] 10.1371/journal.pone.0252757 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome비 인두 면봉에서 SARS-COV-2 바이러스 부하는 불리한 결과의 독립적 인 예측자가 아닙니다.Observational Study Published on 2021-06-212022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 진단, [키워드] Admission Analysis C-reactive protein calculate can not Clinical outcome Composite conducted COVID-19 Cycle threshold value death disease severity Endpoint Final hospital ICU ICU admission Illness severity independent intensive care intensive care unit Lactate lactate dehydrogenase log Logistic regression analysis Mild moderate multivariable analysis multivariable logistic regression nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Neutrophils on admission outcome outcomes Patient patients with COVID-19 performed predict predictor primary endpoint prospective cohort study quartile Risk factors RT-PCR SARS-CoV-2 RNA SARS-CoV-2 viral load severity synthetic Viral viral infection Viral load were used [DOI] 10.1038/s41598-021-92400-y PMC 바로가기 [Article Type] Observational Study