Variable Induction of Pro-Inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In VivoArticle Published on 2021-07-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE2 activity acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody binding blockade blocked clinical outcomes commensal bacteria coronavirus correlated COVID-19 cytokine cytokine expression cytokine production endotoxin exhibited host cell immune responses Impact in vitro induce inducer induction Infection inflammatory cytokine production inhibited inhibitor Interaction Like LPS mechanism MERS Middle East modeling mononuclear cell mucosal tissue Neutralizing pathogenic pathway PBMC Peripheral blood Potential Proinflammatory cytokine promote reagent reagents reported respiratory SARS CoV-2 soluble ACE2 spike Spike protein variable [DOI] 10.3390/ijms22147540 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammationRIG-I 및 MDA5에 의한 SARS-CoV-2 감지는 상피 감염을 대식세포 염증과 연결합니다Article Published on 2021-07-022022-09-10 Journal: The EMBO Journal [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation airway airway epithelial cell airway epithelial cells cause Cell cellular activation COVID‐19 cytokine cytokine production cytoplasmic develop disease downstream effective ENhance epithelial epithelial cell epithelial cells exacerbate exacerbated human macrophage immunology immunopathological induce Infection Inflammation Inflammatory inflammatory mediator Inflammatory mediators inflammatory state inflammatory stimuli inhibiting innate immune pathway innate immune pathways innate immune response Local lung epithelial cell Lung epithelial cells lung epithelium Macrophage macrophage activation macrophages MDA5 mechanism mediators Microbiology, Virology & Host Pathogen Interaction mitigate Pathways produced replicate required RNA RNA sensing robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 stimulate triggering [DOI] 10.15252/embj.2021107826 PMC 바로가기 [Article Type] Article
Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis염증성 사이토카인 폭풍의 심각성은 COVID-19 바이러스 SARS-CoV-2와 같은 RNA 바이러스와 소핵의 상호 작용에 의해 촉진될 수 있습니다. 가설Review Published on 2021-07-012022-09-11 Journal: Mutation research. Reviews in mutation research [Category] SARS, 변종, 유전자 메커니즘, [키워드] affected Aneuploidy Cell cGAS cGAS-STING. chromosomal instability COVID-19 COVID-19 virus cyclic GMP cytokine production Cytokine storm Effect elevated Evidence Factor Frequency high risk Hypothesis immune response immunologically increase individual induce Infection Inflammation Inflammatory cytokine inflammatory cytokine production Interaction interferon leakage lymphocyte mechanism Micronuclei moderate observation pro-inflammatory cytokine pro-inflammatory response reduction RNA RNA virus RNA viruses SARS-CoV-2 SASP secretory senescence Senescence Associated Secretory Phenotype severity stimulator STING susceptible threshold tissue damage virus infection viruses weakened [DOI] 10.1016/j.mrrev.2021.108395 PMC 바로가기 [Article Type] Review
Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19Review Article Published on 2021-06-302022-10-04 Journal: NPJ Regenerative Medicine [Category] 임상, 치료제, [키워드] acute respiratory distress acute respiratory syndrome Adaptive immune response alleviate ARDS caused clinical clinical study clinical trial clinics coronavirus coronavirus disease COVID-19 COVID-19 patient cytokine production Cytokine storm death decrease develop effective Efficacy enrolled evaluate fraction hypoxia immunomodulatory IMPROVE infected patient Inflammatory cytokine lack majority Mesenchymal stem cells Mild-to-moderate mortality rate MSC MSCs multiple organ failure outcome pandemic Patient patients performed placebo-controlled reduce regenerative potential Safe SARS-CoV-2 severe COVID-19 patients severe COVID-19 symptoms severe symptoms Standard of care statistically stem cell Support survival Symptoms syndrome therapeutic therapeutic potential Treatment uncontrolled viral infection [DOI] 10.1038/s41536-021-00147-x PMC 바로가기 [Article Type] Review Article
Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients시스템 면역학 분석, 중증 COVID-19 환자의 면역병인 발생에 대한 폐 및 폐외 조직의 기여도 밝혀Immunology Published on 2021-06-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] activated addition Analysis APOA4 applied ASS1 B-cell B-cells BCL3 caused CBM CCL11 CD34 characterized CHI3L1 chronic inflammation complex contribute COVID-19 COVID-19 pandemic COVID-19 patient COVID19 CXCL1 cytokine cytokine production Cytokine storm Cytokines Cytokines storm DCLRE1C death dendritic cells dramatic increase dysregulated dysregulation eosinophil exacerbated Extrapulmonary extrapulmonary tissue extrapulmonary tissues Health heart heart tissue HLX HSP90AB1 IL2RA IL6 immune response immune responses immunology immunomodulatory effect Immunopathogenesis Inflammation inhibitor investigation ISG20 kidney LILRA5 liver lung lung tissue lung; modulate Monocytes MUC16 MUC17 MUC3A MUC4 MUC5B mucin multi-organ dysfunction NF-κB NF-κB signaling NFASC overexpression PARP14 potential mechanism potential mechanisms PTPN1 pulmonary resulting S100A12 SARS-CoV-2 SARS-COV-2 infection System T-cell T-cells the cytokine storm tissue tissues triggered upregulated WIPF3 [DOI] 10.3389/fimmu.2021.595150 PMC 바로가기 [Article Type] Immunology
Oxidative Stress and Inflammation in SARS-CoV-2- and Chlamydia pneumoniae -Associated Cardiovascular DiseasesReview Published on 2021-06-242022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] acute respiratory syndrome antioxidant antioxidants approach Bacteria cardiovascular cardiovascular disease cardiovascular diseases Chlamydia pneumoniae Compound coronavirus cytokine production Evidence highlight infections Inflammation Inflammatory involved molecular Novel coronavirus oxidative oxidative stress pandemic Pathogenesis pathway pneumoniae provided reactive oxygen specy Respiratory pathogens responsible SARS-CoV-2 therapeutic [DOI] 10.3390/biomedicines9070723 PMC 바로가기 [Article Type] Review
COVID‐19 and the liver – Lessons learnedSupplement Article Published on 2021-06-212022-10-30 Journal: Liver international : official journal of the Inte [Category] COVID-19, MERS, SARS, [키워드] Activation Autoimmune Biochemistry Characteristics characterized cirrhosis coronavirus disease Course COVID‐19 Critical current cytokine production Cytopathic effect disease disease severity elevated Epidemiology Fatty liver hepatocyte high risk hospitalized patient hypoxic Immune cell Immunosuppressive medication include increase in indicated individual Inflammatory response lesson liver Liver damage Liver disease Liver function Liver function test Liver injury Liver transplantation marker mechanism outcome pathological mechanism Patient receiving severity stages susceptibility virus [DOI] 10.1111/liv.14854 PMC 바로가기 [Article Type] Supplement Article
COVID-19: Lung-Centric ImmunothrombosisCellular and Infection Microbiology Published on 2021-06-112022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] activated Activation acute respiratory distress acute respiratory distress syndrome (ARDS) antimicrobial ARDS blood vessel Coagulation factors coronavirus COVID-19 COVID-19 patients cytokine production Cytokine storm cytoplasmic death Evidence favor immunothrombosis Infection innate immune response Local lung epithelia Macrophage microbes NET NETs neutrophil Neutrophil extracellular trap Neutrophils Platelet Pulmonary infection recruitment respiratory tract SARS-CoV-2 syndrome Therapeutic approach virus while [DOI] 10.3389/fcimb.2021.679878 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Prospective Assessment of SARS-CoV-2 Seroconversion (PASS) study: an observational cohort study of SARS-CoV-2 infection and vaccination in healthcare workersSARS-COV-2 SEROCONVERSION (PASS) 연구의 전향 적 평가 : 의료 근로자의 SARS-COV-2 감염 및 예방 접종에 대한 관찰 코호트 연구Study Protocol Published on 2021-06-092022-09-01 Journal: BMC Infectious Diseases [Category] MERS, SARS, 진단, [키워드] Affect Analysis Anti-spike antibody assessment Asymptomatic baseline clinical response Cohort Complete conducted coronavirus coronavirus disease Coronavirus disease 2019 CoV covariates COVID-19 COVID-19 disease COVID-19 disease course cross-reactivity cytokine production determine develop disease symptoms evaluate Frequency glycoprotein HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs HCWs healthcare healthcare worker HKU1 human coronavirus IgG antibodies IgM and IgG immune response immune responses Immune-response immunological individual Infection intensity Killer cell magnitude mononuclear cell natural natural killer cell NL63 number of infected Observational cohort study OC43 pandemic coronavirus participant pauci-symptomatic PBMCs peptide peptide pool performed Peripheral blood Peripheral blood mononuclear cells positive Prospective Prospective Study questionnaire receive respiratory Respiratory disease Respiratory illness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 PCR testing SARS-CoV-2 vaccination SARS-CoV-2 vaccine seroconvert serology analysis severe respiratory illness severity Spike proteins supplementary material Symptom T cell T cell activation T cell response T cell responses tested the SARS-CoV-2 the spike protein vaccination Vaccine viral respiratory with COVID-19 [DOI] 10.1186/s12879-021-06233-1 PMC 바로가기 [Article Type] Study Protocol
A comprehensive review on clinical and mechanistic pathophysiological aspects of COVID-19 Malady: How far have we come?Covid-19 Malady의 임상 및 기계적 병리 생리 학적 측면에 대한 포괄적 인 검토 : 우리는 얼마나 멀리 왔습니까?Review Published on 2021-06-072022-09-10 Journal: Virology Journal [Category] MERS, 치료제, [키워드] ACE2 receptors affecting analyzed approved articles Case report case reports Case series clinical presentation comorbid disease comorbid diseases Comorbidities Comorbidity contributed coronavirus coronavirus disease COVID-19 current cytokine cytokine production damage determine disease manifestation disease severity Effect Entry mechanism host cell host cells immune response include Inflammation irreversible damage lead long term Manifestations mechanism Mortality observational studies organ damage organ system organ systems outbreak pandemic pathology pathophysiologic pathophysiological Pathways patients penetration Prevalence recorded Research retrieved reveal short term Signs and symptoms SPSS Symptoms systemic inflammation Treatment underlying disease Vaccine Viral Viral proteins [DOI] 10.1186/s12985-021-01578-0 PMC 바로가기 [Article Type] Review