downregulated – Page 8 – Communicable Diseases Research

Quantitative mapping of mRNA 3’ ends in Pseudomonas aeruginosa reveals a pervasive role for premature 3’ end formation in response to azithromycin

Pseudomonas aeruginosa에서 mRNA 3 '끝의 정량적 매핑은 아지트로 마이신에 대한 반응으로 조기 3'말단 형성에 대한 광범위한 역할을 보여줍니다.

Research Article

Published on 2021-07-122022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] 3’ end accompanied accumulation Alter antibiotic Antibiotics approach Azithromycin azithromycin treatment cause change changes in chronic infection chronic infections clinical outcomes control gene Culture cystic fibrosis downregulated downregulated gene expression fibrosis Gene Expression Gene regulation Genes growth GTPase Hospital-acquired infection hospital-acquired infections hospitalized patient hospitalized patients immunocompromised individuals impair improve clinical outcome incidence Infection involved Macrolide mechanism molecular mechanism molecular mechanisms MOST mRNA nucleases nucleotide P . aeruginosa Patient persistence planktonic Premature promote provide Pseudomonas aeruginosa quorum reduced Regulation regulatory element respond resulting reveal RNA robust Stress stress response subject Support therapeutic intervention thought transcript Transcription transcriptional transcriptional response treated Treatment turn upregulated genes upregulating virulence
[DOI] 10.1371/journal.pgen.1009634 PMC 바로가기 [Article Type] Research Article

Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1

Immunology

Published on 2021-07-072022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

Cytokine-Induced Modulation of SARS-CoV2 Receptor Expression in Primary Human Nasal Epithelial Cells

Article

Published on 2021-07-052022-10-28
Journal: Pathogens [Category] COVID-19,

Integrative omics provide biological and clinical insights into acute respiratory distress syndrome

통합 omics는 급성 호흡 곤란 증후군에 대한 생물학적 및 임상적 통찰력을 제공합니다.

Meta-Analysis

Published on 2021-07-012022-09-11
Journal: Intensive care medicine [Category] Fulltext, SARS, 유전자 메커니즘,

[키워드] accompanied acting acute respiratory distress acute respiratory distress syndrome African Americans ameliorated Analysis approaches ARDS Biomarker Biomarkers BORCS5 C-reactive protein Causal Causal inference Causality clinical care Comorbidity Control coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity distress downregulated DUSP16 elevated European Europeans Factor genetic heterogeneity genetic susceptibility Genome-wide association study identify Immune cell immune cells in silico Inflammatory bowel disease interleukin interleukin-10 involved Limited loci locus Lung injury mechanism meta-analyses multi Multi-omics Odds ratio pathophysiology performed respiratory distress Respiratory distress syndrome risk susceptibility syndrome target therapeutic potential therapeutic target therapeutic targets vasodilator Vitamin D Vitamin D supplementation was determined
[DOI] 10.1007/s00134-021-06410-5 PMC 바로가기 [Article Type] Meta-Analysis

The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity

Research Article

Published on 2021-06-282022-10-29
Journal: PLoS Pathogens [Category] COVID-19, MERS, SARS,

[키워드] Alpha Caco-2 Calu-3 Calu-3 cell line Cell cell line cell type cells cellular entry cellular protease Chronic diseases Colon comorbid disease comorbid diseases Comorbidity Control Coronaviruses COVID-19 outbreak COVID-19 patient COVID-19 patients dataset datasets death decrease described determine diabete diabetic patient disease disease severity down-regulated down-regulation downregulated drastic reduction Endocrine evaluated example expression Factor Features Health implication increase in inhibit inhibiting inhibitor kidney knockdown liver malignancies mechanism New coronavirus number of infected overexpressing overexpression pancreatic islet pandemic patients priming regulated Regulation S protein SARS-CoV-2 SARS-CoV-2 viral infection scRNA-seq data secretory cell serine protease inhibitor serine protease TMPRSS2 severity shown similarity SPINT2 susceptibility tissues TMPRSS2 triggered Tumor Type unique viral entry Viral load virulence virus while
[DOI] 10.1371/journal.ppat.1009687 PMC 바로가기 [Article Type] Research Article

The Altered Anatomical Distribution of ACE2 in the Brain With Alzheimer’s Disease Pathology

Cell and Developmental Biology

Published on 2021-06-252022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

H-Ras gene takes part to the host immune response to COVID-19

Perspective

Published on 2021-06-252022-10-31
Journal: Cell Death Discovery [Category] COVID-19,

Comparison of renal histopathology and gene expression profiles between severe COVID-19 and bacterial sepsis in critically ill patients

중증 코로나19와 중증 환자의 세균성 패혈증 사이의 신장 조직병리 및 유전자 발현 프로파일 비교

Research

Published on 2021-06-102022-09-11
Journal: Critical Care [Category] MERS, 유전자 메커니즘, 치료제,

[키워드] ACE2 mRNA Activation Acute kidney injury acute tubular necrosis AKI AKI patient Analysis angiopoietin Bacterial Bacterial sepsis biopsy cadherin CD31 Cohort collected Control tissue controls COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient death detect determine disease onset downregulated driving endothelial endothelial integrity Extensive feature Fold change gene expression profile histopathological Histopathology ICU ICU admission individual Inflammation Injury involved kidney lack lung tissue marker mechanism Microvascular thrombosis mRNA mRNA expression mRNA level mRNA levels normal not differ observation pathophysiological Patient patients patients with COVID-19 PCR positive peritubular renal renal tissue required Result SARS-CoV-2 RNA Sepsis severe COVID-19 supplementary material the timing thrombi thrombosis tissue total nephrectomy Tubular Necrosis VE-cadherin was obtained
[DOI] 10.1186/s13054-021-03631-4 PMC 바로가기 [Article Type] Research

Derangement of cell cycle markers in peripheral blood mononuclear cells of asthmatic patients as a reliable biomarker for asthma control

Article

Published on 2021-06-042022-10-04
Journal: Scientific Reports [Category] 바이오마커,

[키워드] ABCA1 ANLN approach Asthma asthma patient asthmatic asthmatic patient Asthmatic patients Biomarker Blood Bronchial epithelium Cell complex interplay Comprehensive derangement deviate downregulated driver examined Factor fibroblast fibroblasts Gene Expression GPRC5A healthy help heterogeneity homeostasis identify immunology in vitro KRT8 lung marker MKI67 molecular basis Molecular biology mononuclear cell NEK2 pathway Patient PBMC Peripheral blood phenotype progression proliferation qPCR recruited representing RRM2 SERPINE1 SFN Systems biology Th2 therapy tissue tissue remodeling TOP2A transcriptomic data upregulated validation were used wheeze
[DOI] 10.1038/s41598-021-91087-5 PMC 바로가기 [Article Type] Article

Extracellular Vesicle Capture by AnTibody of CHoice and Enzymatic Release (EV‐CATCHER): A customizable purification assay designed for small‐RNA biomarker identification and evaluation of circulating small‐EVs

Technical Report

Published on 2021-06-032022-10-29
Journal: Journal of Extracellular Vesicles [Category] COVID-19, MERS,