endothelial damage – Page 8 – Communicable Diseases Research

Characteristics of Large-Vessel Occlusion Associated with COVID-19 and Ischemic Stroke

Observational Study

Published on 2020-12-012022-10-05
Journal: AJNR. American journal of neuroradiology [Category] SARS, 임상,

Improvement of COVID‐ 19 with renal failure and paralytic ileus by using steroids

Case Report

Published on 2020-11-292022-10-29
Journal: Respirology Case Reports [Category] COVID-19,

Endothelial Damage in Acute Respiratory Distress Syndrome

Review

Published on 2020-11-202022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

Circulating Biomarkers of COVID-19-Triggered Endotheliopathy: From Conjecture to Certainty

Conference abstract

Published on 2020-11-042022-10-05
Journal: Blood [Category] 바이오마커,

[키워드] Activation acute phase reactants Admission affecting analyzed appear Biomarker Blood board Boehringer Ingelheim certainty chest imaging circulating clinical collected complement Complication Conjecture contribute Control controls coronavirus Course COVID-19 COVID-19 patient COVID-19 patients Critical Culture Degradation detection diagnostic disease download dsDNA elevated ELISA test endothelial Endothelial cell endothelial damage endothelial function endothelial injury evaluated figure form funding healthy donor Hoffmann-La Roche Hospitalization identify immunofluorescence Inflammatory information Injury janssen Jazz Lancet Level marker Mortality multiple organs Nasopharyngeal swab NET NETs Neutrophil extracellular trap no significant difference non-critically ill patient non-infectious not differ notable Novartis pathophysiology Patient plasma Pneumonia positive potentially life-threatening prognostic protein C pulmonary complication radiological reduced responsible Result Science Septic shock Sharp Siemens Healthineers significantly significantly higher significantly increased significantly lower speaker Stress syndrome systemic inflammatory response Takeda the disease therapeutic intervention Therapeutics thrombotic vWF were assessed were measured were used
[DOI] 10.1182/blood-2020-142311 [Article Type] Conference abstract

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

COVID-19의 내피 손상 및 혈전성 미세혈관병증: 렉틴 경로 억제제 나르소플리맙으로 치료

Article

Published on 2020-11-012022-09-11
Journal: Immunobiology [Category] SARS, 진단, 치료법,

[키워드] activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome Adverse drug reaction Adverse drug reactions anticoagulant effects ARDS Arterial thrombosis Autopsies baseline bind C-reactive protein C-reactive protein (CRP circulating compassionate use complement Complement activation complications Continuous Positive Airway Pressure control group Coronavirus-2 COVID-19 COVID-19 patient CPAP CRP during treatment effective Endothelial cell endothelial cell damage endothelial damage endothelial injury enzyme human immunoglobulin IgG4 IL-6 IL-8 Immunoglobulin Inflammation inhibit inhibitor Injury interleukin interleukin-6 interleukin-8 intubation Lactate lactate dehydrogenase LDH lectin lectin pathway life-threatening Lung injury mannan MASP-2 monoclonal antibody Mortality Narsoplimab nucleocapsid protein pathogenic Patient positive airway pressure reducing reduction reported respiratory respiratory distress Respiratory distress syndrome resulting retrospective SARS-CoV-2 Serine serine protease serum Serum IL-6 Serum level serum levels Severe acute respiratory syndrome severe acute respiratory syndrome-associated coronavirus-2 significantly higher survived sustained syndrome thrombosis thrombotic thrombotic event Thrombotic events thrombotic risk treat Treatment treatment for COVID-19 was used were assessed were used
[DOI] 10.1016/j.imbio.2020.152001 PMC 바로가기 [Article Type] Article

Hyperthrombotic Milieu in COVID-19 Patients

Review

Published on 2020-10-312022-10-31
Journal: Cells [Category] COVID-19, MERS, SARS,

[키워드] alteration cascade clinically Coagulation coagulation cascade Coagulopathy component coronary syndrome coronavirus COVID-19 COVID-19 infection develop dominant Embolism endothelial cell damage endothelial damage endotheliopathy events Evidence experience extrinsic fibrinolytic implication Kidney failure marker mechanism Microvascular thrombosis milieu Mortality Multisystem organ failure Myocardial infarction nuance Occurrence Outbreaks parameter patients patients with COVID-19 predictor probe Respiratory failure risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 shown stroke strokes systemic anticoagulation systemic manifestations the patient therapeutic targets therapy Thromboembolic event Thromboprophylaxis thrombosis triggered venous venous thromboembolic VTE while widespread with COVID-19
[DOI] 10.3390/cells9112392 PMC 바로가기 [Article Type] Review

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Article

Published on 2020-10-292022-10-06
Journal: Blood [Category] SARS, 진단,

[키워드] activate Activation acute respiratory syndrome Alternative pathway animal antibody APC Atypical blocked C3c catastrophic cells clinical manifestation complement Complement pathway contagious coronavirus COVID-19 Direct disease end-organ end-organ damage endothelial damage Evidence explain Human Hypothesis in vitro inactivation Injury killing mechanism mice mitigate Myocardial infarction Prevent renal respiratory virus SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike proteins Spike protein stroke subunit supernatant syndrome target cells the N protein the SARS-CoV-2 thrombosis Trigger upstream uremic syndrome
[DOI] 10.1182/blood.2020008248 PMC 바로가기 [Article Type] Article

More than Pneumonia: Distinctive Features of SARS-Cov-2 Infection. From Autopsy Findings to Clinical Implications: A Systematic Review

Review

Published on 2020-10-232022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] Acute kidney injury (AKI) acute respiratory distress acute respiratory distress syndrome (ARDS) alveolar ARDS Autopsies Autopsy autopsy study bronchopneumonia Case series clinical clinical feature Comorbidity Complete contributed COVID-19 COVID-19 disease Cytokine storm dataset death died diffuse alveolar damage (DAD) disease endothelial damage Features finding gold standard histopathological features inclusion criteria Infection Inflammatory management Microthrombosis multiple organ failure pathogen patients with COVID-19 Post-mortem producing provided recommendation Research resulting retrospective review subject syndrome systematic review Therapeutic approach Thromboembolism was performed with COVID-19
[DOI] 10.3390/microorganisms8111642 PMC 바로가기 [Article Type] Review

Host–Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 Pathogenesis

Original Article

Published on 2020-10-172022-10-29
Journal: TH Open: Companion Journal to Thrombosis and Haemostasis [Category] COVID-19,

[키워드] Activation acute respiratory distress Anticoagulant ARDS Biotechnology Coagulation coagulation factor Combination conducted Convolution COVID-19 COVID-19 pathogenesis COVID-19 patients database dataset datasets DEGs DHX9 differentially expressed gene disease effect size endothelial damage enrichment analysis expression data Gene Expression Helicase highly pathogenic host–virus interaction implication IMPROVE Infection Inflammation KAT2B low molecular weight lung lysine management mechanism Meta-analysis NCBI-GEO network novel corona virus observation Pathway enrichment analysis Pathways Protein PSMB2 random effect RBX1 RELA Replication Revealed SARS-CoV-2 Sepsis shown signature subsequent subunit suggested syndrome Therapeutic strategies thrombosis thrombotic TP53 transcriptomics Treatment Venous Thromboembolism virus VTE was done was used were used worsened
[DOI] 10.1055/s-0040-1721706 PMC 바로가기 [Article Type] Original Article

Angiogenesis, hereditary hemorrhagic telangiectasia and COVID-19

혈관신생, 유전성 출혈성 모세혈관확장증 및 COVID-19

Case Reports

Published on 2020-10-142022-09-10
Journal: Angiogenesis [Category] 변종, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus-2 ACVRL1 Adult patients Angiogenesis characterized Clinical course Clinical data coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient COVID-19 pneumonia discharged disease endothelial damage endothelial injury Epistaxis Evidence Hemorrhagic Hereditary Hereditary hemorrhagic telangiectasia investigator mechanical ventilation multicenter open pathogenic pathogenic variant pathologic Patient patients Pneumonia Prevalence provoke rare disease rare diseases registry respiratory SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) telangiectasia Vascular worsening
[DOI] 10.1007/s10456-020-09755-5 PMC 바로가기 [Article Type] Case Reports