Pathogenic mechanisms of influenza A(H1N1)pdm09 infection elucidated on gene expression profilingArticle Published on 2013-10-012023-06-24 Journal: Pediatrics international : official journal of the [Category] 신종인플루엔자, [키워드] central nervous system manifestations gene expression profile Influenza A(H1N1)pdm09 Pneumonia [DOI] 10.1111/ped.12139
Type I interferon receptor-independent and -dependent host transcriptional responses to mouse hepatitis coronavirus infection in vivoResearch Article Published on 2009-08-032022-10-28 Journal: BMC Genomics [Category] Coronavirus, MERS, [키워드] Analysis Antiviral association BALB/c BALB/c mice Brain brains compared coronavirus Coronavirus infection correlated CoV CoV infection Culture days post infection demonstrated detected different differentially expressed effector expression profiling Fold change Gene Gene Expression gene expression profile Host transcriptional response identify IFN response IFN-inducible gene IFN-γ in vivo inducer Infected Infection infections interferon knowledge less MHV mice mouse hepatitis performed Profiling Protective protective role receptor response responses Result robust shown significantly Strains susceptibility susceptible tissue transcriptional responses Type type I Type I IFN type I interferon type II IFN Viral load virus were used while whole-genome [DOI] 10.1186/1471-2164-10-350 PMC 바로가기 [Article Type] Research Article
Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected MacaquesResearch Article Published on 2007-08-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activated acute phase acute respiratory distress acute respiratory syndrome Admission Adult against SARS-CoV analyzed Antiviral antiviral signaling Atypical Author cause Cell cells characterized chemokine genes chemokines circumvent Complication coronavirus Critical cynomolgus macaque cytokine demonstrated early IFN signaling Effect event examined functional gene expression profile gene signature Genomics highlight Host host response IFNs IL-8 immune response immunohistochemistry in vitro experiments individuals induction Infection innate immune response Innate immunity intensive care involved IP-10 lung Lung pathology macaque macaques nuclear translocation Pathogenesis pathogenic pathway phosphorylated Pneumonia protective immune response regulated required SARS patient SARS-CoV SARS-CoV infection SARS-CoV–infected cells severe shown Stat1 subset syndrome Transcription transcription factor type I interferon viral infection virus virus replication [DOI] 10.1371/journal.ppat.0030112 PMC 바로가기 [Article Type] Research Article