genetic variants

[키워드] 2-sample MR 25-hydroxy vitamin D 25OHD 25OHD level 25OHD levels 95% CI analyses Analysis association associations circulating confounder confounders confounding variables Control control group control groups controlled trials controls COVID-19 COVID-19 case COVID-19 cases COVID-19 Host Genetics Initiative COVID-19 susceptibility deficiency described determined by ecological Ecological studies European Evidence General population Genetic genetic determinant genetic determinants genetic evidence genetic instrument genetic instruments Genetic variant genetic variants Genome-wide association study Guillaume GWAS GWASs had no horizontal pleiotropy Hospitalization IMPROVE in some in vitro Increased individual individuals with COVID-19 initiative instrument bia instrumental variables inverse-weighted MR Laboratory testing large-scale vitamin D randomized trials limit logarithmic scale mendelian randomization Mendelian randomization studies Mendelian randomization study meta-analytic methods observational studies observé Odds ratio Other outcome outcomes participant Population predicted PROTECT provide provided Randomized controlled trial Randomized controlled trials randomized trials rationale reduce reflected removal researcher risk SARS-CoV-2 positivity Sensitivity analyses sensitivity analysis severe disease severity Standard deviation Support supported susceptibility therapeutic therapy trials UK biobank variant variants Vitamin D vitamin D deficiency vitamin D level vitamin D levels Vitamin D Mendelian randomization vitamin D Mendelian randomization studies Vitamin D supplementation vitamin D supplementation randomized trials was determined were used with COVID-19 worsened
[DOI] 10.1371/journal.pmed.1003605 PMC 바로가기 [Article Type] Research Article