Using test positivity and reported case rates to estimate state-level COVID-19 prevalence and seroprevalence in the United States테스트 양성 및 보고된 사례 비율을 사용하여 미국의 주 수준 COVID-19 유병률 및 혈청 유병률 추정Research Article Published on 2021-09-072022-09-12 Journal: PLoS Computational Biology [Category] 진단, [키워드] approach average Bayesian calibrated Coverage COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic COVID-19 testing credible interval data-driven diagnostic epidemiological estimate geometric geometric mean IMPROVE independent infection prevalence infections Inference interval mathematical New York pandemic Prevalence public health Public health response Public health responses reported respond Seroprevalence Spread spread of COVID-19 the United State United State United States used to evaluate vaccination Vermont [DOI] 10.1371/journal.pcbi.1009374 PMC 바로가기 [Article Type] Research Article
Preliminary evidence of blunted humoral response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients treated with ocrelizumab오크렐리주맙으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 mRNA 백신에 대한 체액 반응 둔화의 예비 증거Article Published on 2021-09-012022-09-11 Journal: Neurological Sciences [Category] MERS, SARS, 진단, 치료기술, [키워드] all subject all subjects Anti-spike anti-Spike IgG Antibody Units baseline BAU binding antibody units BNT162b2 Case series case sery collected COVID-19 COVID-19 infection develop DiaSorin disease expand first dose geometric geometric mean health-care healthy subject healthy subjects humoral Humoral response IgG antibodies IgG antibody immunogenicity Infection International international standard majority mounted mRNA mRNA vaccine Multiple multiple sclerosis Ocrelizumab patients treated preliminary evidence relapsing SARS-CoV-2 SARS-CoV-2 mRNA vaccine SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARSCoV-2 second dose second dose of vaccine sera serum sample serum samples Spike protein tested Therapies treated unit Vaccine were expressed [DOI] 10.1007/s10072-021-05397-7 PMC 바로가기 [Article Type] Article
High-Dose Oral and Intravenous Rifampicin for the Treatment of Tuberculous Meningitis in Predominantly Human Immunodeficiency Virus (HIV)-Positive Ugandan Adults: A Phase II Open-Label Randomized Controlled Trial주로 인간 면역 결핍 바이러스 (HIV)-양성 우간다 성인에서 결핵성 수막염의 치료를위한 고용량 경구 및 정맥 내 리팜피신 : 2 상 공개 라벨 무작위 대조 시험Major Articles and Commentaries Published on 2021-09-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 95% confidence interval Administered Adults Adverse adverse events AUC C max CD4 cerebrospinal fluid Concentration Controlled CSF current dose enrolled event geometric geometric mean High-dose HIV Human Human immunodeficiency virus immunodeficiency virus IMPROVE inhibitory concentration intensified therapy International interquartile range intravenous intravenously majority median Meningitis minimal inhibitory concentration not differ occurred Open-label open-label trial oral outcome participant Participants Patient patients performed pharmacokinetic phase PK data plasma Primary outcome Primary outcomes Randomized regimen Result rifampicin Safe serum Standard of care Standard-of-care sustained TBM therapeutic Toxicity Trial Tuberculosis tuberculous tuberculous meningitis undetectable with HIV would increase [DOI] 10.1093/cid/ciab162 PMC 바로가기 [Article Type] Major Articles and Commentaries
The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serumSARS-CoV-2 회복기 혈청의 중화 활성 및 RBD 결합에 대한 스파이크 N501Y 돌연변이의 영향Article Published on 2021-09-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] 95% CI Amino acid amino acids ANOVA Anti-RBD IgG Anti-S1 antibody Antibody binding assays B.1.1.7 B.1.351 binding binding domain clinician collected convalescent sera convalescent serum COVID-19 COVID-19 patient determine enzyme immunoassay evaluated geometric geometric mean geometric mean titer GMT Hong Kong IgG isolates K417N Lineage mean difference Michael microneutralization N501Y N501Y mutation neutralization Neutralizing activity neutralizing antibody Neutralizing antibody Spike protein receptor binding domain NSP2 one-way ANOVA Patient positive Protein RBD RBD binding Receptor binding Receptor binding domain recovered COVID-19 patient reduced Richard SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 lineage SARS-CoV-2 N501Y variant B.1.1.7 sensitivity sera serum service significantly spike Spike protein Spike receptor binding domain Spread statistically susceptibility symptom onset tested variant variants virus virus variant virus variants viruses VoC VOC. was determined wild-type [DOI] 10.1016/j.ebiom.2021.103544 PMC 바로가기 [Article Type] Article
An Immunogenicity Report for the Comparison between Heterologous and Homologous Prime-Boost Schedules with ChAdOx1-S and BNT162b2 VaccinesArticle Published on 2021-08-252022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI Administered antibody AstraZeneca BNT BNT162b2 ChAdOx1-S covariate COVID-19 COVID-19 vaccine France geometric healthcare worker Heterologous homologous homologous schedule hospital humans IgG antibody immune response immunogenicity immunological mRNA negative correlation no significant difference of BNT162b2 outcome participant Pfizer/BioNTech remained report robust SARS-CoV-2 IgG antibodies schedule second dose second vaccination serology test serum significantly higher vaccination vaccination schedule Vaccinations Vaccine vaccine group viral vectored vaccines [DOI] 10.3390/jcm10173817 PMC 바로가기 [Article Type] Article
Deep geometric representations for modeling effects of mutations on protein-protein binding affinityResearch Article Published on 2021-08-042022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, [키워드] addition Amino acid approach binding affinity change dataset datasets deep develop drug design Effect effort ENCODE experiments feature functional geometric in silico Approach Interaction labor-intensive modeling Mutation mutations predict Protein protein complex Protein design protein-protein interaction Proteins RBD Research SARS-CoV-2 antibody structures the binding affinity the receptor-binding domain the S protein three-dimensional structure time-consuming Topology [DOI] 10.1371/journal.pcbi.1009284 PMC 바로가기 [Article Type] Research Article
Topological data analysis model for the spread of the coronavirusResearch Article Published on 2021-08-042022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Algorithm comparison Complete coronavirus COVID-19 COVID-19 cases Data analysis feature geometric growth rate information pandemic progression resulting Spread topological data analysis variety [DOI] 10.1371/journal.pone.0255584 PMC 바로가기 [Article Type] Research Article
BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial우간다 신생아의 이종 감염성 질환에 대한 BCG- 유도 비특이적 영향 : 조사관 맹인 무작위 대조 시험Articles Published on 2021-07-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] 1:1 Abstract addition age all-cause mortality Alter analysed analyses assigned BCG BCG vaccination benefit Birth blind block size block sizes blood sample Blood samples change clinically clinician Comparisons computer-generated Concentration Consent contributed Controlled Controlled trial Cord blood discharged Effect Effects eligible enrolled Entebbe Families finding Follow-up for inclusion funding geometric geometric mean geometric mean ratios gestational age group hazard ratio healthy hepcidin Heterologous hospital IFNγ IL-10 IL-1β IL-6 IL1B IL6 immunological incidence increase in Infant Infants infections Infectious disease inhibited Innate immunity international standard investigated investigators life Luganda material medical intervention modified intention-to-treat mononuclear cell morbidity morbidity and mortality mother Neonatal neonatal period no significant difference non-specific number outcome parent parents participant Peripheral blood Peripheral blood mononuclear cells primary clinical outcome promoter promoter region PROTECT randomisation randomised randomised controlled trial Randomly receive recruited reduce reductions reductions in Registered required saturation Standard Standard dose stratified by sex TNF Transferrin translation Trial Tuberculosis Uganda vaccination Wellcome Trust were excluded with HIV withdrawn [DOI] 10.1016/S1473-3099(20)30653-8 PMC 바로가기 [Article Type] Articles
Niclosamide inhalation powder made by thin-film freezing: Multi-dose tolerability and exposure in rats and pharmacokinetics in hamsters박막 동결로 만든 니클로사미드 흡입 분말: 쥐의 다중 용량 내약성 및 노출 및 햄스터의 약동학Article Published on 2021-06-152022-09-12 Journal: International journal of pharmaceutics [Category] MERS, SARS, 진단, [키워드] Administered administration Antiviral approved Concentration demonstrated develop drug candidate Dry Dry powder inhaler evidenced exhibited film fraction freezing geometric GSD hamster histopathology analysis Infection lung Lung pharmacokinetics Lungs median medication MMAD niclosamide oral bioavailability overcome pharmacological primary site pulmonary Pulmonary administration required Safe SARS-CoV-2 SARS-COV-2 infection Standard deviation tested Thin Thin Film Freezing. Tolerability was used [DOI] 10.1016/j.ijpharm.2021.120701 PMC 바로가기 [Article Type] Article
Partner-delivered HIV self-test kits with and without financial incentives in antenatal care and index patients with HIV in Malawi: a three-arm, cluster-randomised controlled trialArticles Published on 2021-06-152022-10-30 Journal: The Lancet. Global health [Category] COVID-19, [키워드] 95% CI adjusted administration ANC antenatal care approach ART assigned Cluster Clusters Cohort computer-generated Contact Controlled trial diagnosed Diagnosis distribution eligible eligible patient enrolment finding funding geometric Government Health HIV HIV testing identify IMPROVE incidence rate initiative intention to treat Intervention lockdowns male nine occurred offered offset Open-label Patient patients patients with HIV Pragmatic Pregnancy Primary outcome proportion random Randomly receiving recruited Registered reported resulting risk secondary significantly more standard care standard care group Standard of care tested the mean Trial with HIV women [DOI] 10.1016/S2214-109X(21)00175-3 PMC 바로가기 [Article Type] Articles