Biomarker candidates for progression and clinical management of COVID-19 associated pneumonia at time of admission입원 시점에 COVID-19 관련 폐렴의 진행 및 임상 관리를위한 바이오 마커 후보Article Published on 2022-01-122022-09-10 Journal: Scientific Reports [Category] 바이오마커, 치료기술, 치료법, [키워드] administration Admission Biomarker Biomarkers candidate Candidates change Clinical management Clinical practice Coagulation COG5 complement Control COVID-19 COVID-19 prognosis Critical critical condition critical patients differentially expressed Evolution expression FDR FIVE glucocorticoid Glucocorticoids group Hospital admission Hospital stay hospitalized COVID-19 identify immunoglobulins Infectious diseases Inflammation Lipid metabolism MOST OAS3 over-expressed pathophysiology Patient patients plasma sample plasma samples Pneumonia Potential biomarker potential biomarkers priority Prognosis Prognostic factor progression Protein proteome reached Sample selected specific treatment Study design subject therapeutic strategy therapy Tocilizumab Treatment were used [DOI] 10.1038/s41598-021-04683-w PMC 바로가기 [Article Type] Article
2021 update of the EULAR points to consider on the use of immunomodulatory therapies in COVID-19COVID-19에서 면역조절 요법의 사용에 대해 고려해야 할 EULAR 포인트의 2021 업데이트Practice Guideline Published on 2022-01-012022-09-12 Journal: Annals of the rheumatic diseases [Category] Fulltext, SARS, 진단, [키워드] Baricitinib biological therapy clinical trial Combination conducted Consensus convalescent plasma COVID-19 COVID-19 case Critical early phase Efficacy Evidence glucocorticoid Glucocorticoids IL-1 immunomodulator immunomodulatory therapy immunosuppressed patients International Involvement Janus kinase inhibitor Kinase inhibitor literature review moderate monoclonal antibody Oxygen therapy patients Population robust selected Stratification subgroup Support systemic inflammatory disease the disease therapeutic approaches therapy Tocilizumab Tofacitinib [DOI] 10.1136/annrheumdis-2021-221366 PMC 바로가기 [Article Type] Practice Guideline
Herpes zoster in SLE: prevalence, incidence and risk factorsSLE에서 대상포진: 유병률, 발생률 및 위험 요인Article Published on 2022-01-012023-06-01 Journal: Lupus science & medicine [Category] 대상포진, 두창, 수두, 홍역, [키워드] Glucocorticoids Health care outcome assessment systemic lupus erythematosus [DOI] 10.1136/lupus-2021-000574 PMC 바로가기
Tocilizumab or glucocorticoids treatment for patients with SARS-CoV-2 pneumonia: An observational studySARS-CoV-2 폐렴 환자에 대한 토실리주맙 또는 글루코코르티코이드 치료: 관찰 연구Observational Study Published on 2022-01-012022-09-12 Journal: The Brazilian journal of infectious diseases : an [Category] SARS, 임상, 진단, [키워드] 95% CI baseline calculated consecutive patient Corticosteroids covariates COVID-19 death Follow-up glucocorticoid Glucocorticoids Hospitalized intubation Methylprednisolone outcome Patient patients hospitalized patients with SARS-CoV-2 Primary outcome Probability receiving reduce reduction Result retrospective cohort study SARS-CoV-2 SARS-CoV-2 pneumonia secondary outcome severe COVID-19 Therapies Tocilizumab treated Treatment two groups Weighting [DOI] 10.1016/j.bjid.2021.101702 PMC 바로가기 [Article Type] Observational Study
RBC-hitchhiking chitosan nanoparticles loading methylprednisolone for lung-targeting delivery폐-표적 전달을 위해 메틸 프레드니솔론을 로딩하는 RBC-Hitchhiking 키토산 나노 입자Article Published on 2022-01-012022-08-31 Journal: Journal of controlled release : official journal o [Category] SARS, 치료제, [키워드] accumulation acute lung injury acute respiratory distress acute respiratory distress syndrome AUC cause chitosan Chitosan nanoparticle chronic administration circulation Circulation time cytokine Cytokine storm syndrome Cytokines distribution drug effective erythrocyte erythrocytes facilitated Fluorescein glucocorticoid Glucocorticoids High dose high mortality hitchhiking hyper-inflammation IL-6 in vivo indicated Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibit inhibited injection Interaction leads lipopolysaccharide liver lung Lung injury Lungs Methylprednisolone Methylprednisolone sodium succinate patients with COVID-19 pharmacokinetic plasma concentration RATs RBC-hitchhiking. red blood cell red blood cells reduce respiratory distress Respiratory distress syndrome Side effects significantly significantly higher sodium sodium succinate syndrome tissue TNF-α Treatment treatment groups [DOI] 10.1016/j.jconrel.2021.12.018 PMC 바로가기 [Article Type] Article
Vitamin D: Dosing, levels, form, and route of administration: Does one approach fit all?Article Published on 2021-12-232022-10-28 Journal: Reviews in Endocrine & Metabolic Disorders [Category] COVID-19, SARS, [키워드] administration affecting appear approach bone clinical conditions condition Conference COVID-19 deficiency Diabetes Mellitus different disease Dosing Extraskeletal effects General population Glucocorticoids greater healthy indicated International International Conference kidney liver management mechanism metabolism obesity Osteoporosis outcomes parathyroid hormone Parenteral Patient populations SARS-COV-2 infection skeletal Specific syndrome therapeutic to define treated Vitamin Vitamin D vitamin D administration vitamin D level Vitamin D supplementation [DOI] 10.1007/s11154-021-09693-7 PMC 바로가기 [Article Type] Article
Praktische Empfehlungen zum Screening und Management von Funktionsstörungen der Nebennierenrinde bei einer akuten SARS-CoV-2-InfektionSchwerpunkt: Nebennierenerkrankungen Published on 2021-12-202022-10-29 Journal: Der Internist [Category] COVID-19, SARS, [키워드] „Coronavirus disease 2019“ (COVID-19) Addison disease Adrenal cortex insufficiency, secondary Coronavirus disease 2019 (COVID-19) Cushing syndrome Cushing-Syndrom Glucocorticoids Glukokortikoide Morbus Addison SARS-CoV‑2 Screening Sekundäre Nebennierenrindenfunktionsstörungen [DOI] 10.1007/s00108-021-01236-1 PMC 바로가기 [Article Type] Schwerpunkt: Nebennierenerkrankungen
Antirheumatic Drugs against COVID-19 from the Perspective of RheumatologistsReview Published on 2021-12-022022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] activate anti-IL-1 Antigen antirheumatic Antirheumatic drugs Baricitinib blockade Chloroquine clinical impact Colchicine Coronavirus disease 2019 Course COVID-19 cytokine Cytokine storm Disease progression Diseases drug drugs effective expected Glucocorticoids Hydroxychloroquine Immune cell immunomodulatory immunosuppressants immunosuppressive drug Immunosuppressive treatment Inflammatory cytokines inhibitor inhibitors Janus kinase inhibitor management mechanism mechanism of action Necrosis pandemic Pathogenesis pathophysiology patient death prevent disease progression Rheumatic diseases sarilumab SARS-CoV-2 Stage the cytokine storm the disease Tocilizumab Tofacitinib treatment for COVID-19 viral replication [DOI] 10.3390/ph14121256 PMC 바로가기 [Article Type] Review
Outcomes of COVID-19 in patients with primary systemic vasculitis or polymyalgia rheumatica from the COVID-19 Global Rheumatology Alliance physician registry: a retrospective cohort studyResearch article Published on 2021-12-012022-10-05 Journal: The Lancet Rheumatology [Category] 유전자 메커니즘, [키워드] age Alliance Analysis antibody college Comorbidity conditions COVID-19 COVID-19 in patient COVID-19 severity cytoplasmic death defined demographic factor diagnosed with COVID-19 died disease Disease activity Diseases eligible patient European Factor female finding funding giant cell arteritis glucocorticoid Glucocorticoids had more high risk High-dose higher odd hospitalisation hospitalised male medication men moderate number of comorbidities obesity Odds ratio Older ordinal logistic regression organ damage outcome Patient patients Prednisolone receive supplemental oxygen reported retrospective cohort study Risk factors severe COVID-19 severe disease Sex smoking status stratified Subtypes supplemental oxygen syndrome Treatment Vasculitis Ventilation were used with COVID-19 women [DOI] 10.1016/S2665-9913(21)00316-7 [Article Type] Research article
Effect of High-Titer Convalescent Plasma on Progression to Severe Respiratory Failure or Death in Hospitalized Patients With COVID-19 Pneumonia A Randomized Clinical TrialCOVID-19 폐렴을 가진 입원 환자에서 중증 호흡 부전 또는 사망으로의 진행에 대한 하이 튜터 회복기 혈장의 효과 무작위 임상 시험Randomized Controlled Trial Published on 2021-11-292022-08-13 Journal: JAMA Network Open [Category] MERS, SARS, 임상, [키워드] 1:1 95% CI Adverse adverse events age clinical clinical end point clinical trial Composite control group convalescent plasma convalescent plasma group COVID-19 COVID-19 pneumonia CP and ST CP group CP plus ST CP plus standard therapy death defined did not reduce Effect Efficacy eligible enrolled Enrollment evaluate event experimental group failure finding fraction Glucocorticoids heparin high-titer anti–SARS-CoV-2 CP high-titer CP hospitalized patient hospitalized patients Importance infused intravenous IQR Italy Low–molecular weight heparin maximum measure mechanical ventilation Microneutralization test moderate to severe moderate to severe COVID-19 pneumonia modified intention-to-treat not significantly different objective occurred Odds ratio Open-label oxygen partial pressure participant Patient patients patients with COVID-19 patients with moderate plasma Pneumonia Point primary end point Primary outcome progression randomization randomized clinical trial randomized patient receive recommendations Registration Relevance Remdesivir respiratory Respiratory failure Result setting Severe COVID-19 pneumonia severe respiratory failure ST alone standard care Standard therapy the median treat treated Trial Volume volume of infused CP with COVID-19 worsening worsening respiratory failure [DOI] 10.1001/jamanetworkopen.2021.36246 PMC 바로가기 [Article Type] Randomized Controlled Trial