Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
COVID-19 환자의 바이러스 에피토프 프로파일링은 교차 반응성과 심각도의 상관 관계를 보여줍니다
Research Article
[키워드] acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
Affect
age
Alanine
Analysis
antibody
Antibody detection
antibody epitope
antibody epitopes
antibody repertoire
Antibody Response
Antibody responses
Antibody-dependent enhancement
antiviral antibodies
antiviral antibody
Asymptomatic
caused
circulating
clinical outcomes
colds
common-cold
Control
controls
coronavirus
coronavirus disease
Coronavirus disease 2019
coronavirus strains
Coronaviruses
correlation
Course
covariates
COVID-19
COVID-19 patient
COVID-19 severity
Critical
cross-react
cross-reactive antibody
cross-reactivity
cytomegalovirus
death
deep
Demographic variables
detect
diagnostic
diagnostics
disease
disease severity
distress
enzyme-linked immunosorbent assays
epitope
epitope mapping
Epitopes
exacerbate
examination
exhibited
explain
females
Fever
functional
Gender
generate
gold
herpes simplex
herpes simplex virus
Herpes Simplex Virus 1
Hospitalization
Hospitalized
hospitalized patients
human coronaviruses
human sera
humans
humoral
Humoral response
humoral responses
hypothese
hypotheses
immune
immunogenicity
incidence
individual
individuals
infect
infected with SARS-CoV-2
Infection
infections
interactions
Isolation
knowledge
machine
machine-learning
male
mapped
Mild
Mutagenesis
Neutralizing
Neutralizing antibodies
neutralizing antibody
not need
notable
nucleoprotein
ORF1
outcome
outcomes
Patient
patient cohort
peptide
peptides
performed
predicted
probe
Profiling
Protein
proteome
proteomes
raise
rationale
required
respiratory
respiratory distress
Respiratory system
response
responses
reveal
SARS-CoV-2
SARS-CoV-2 antibody
SARS-CoV-2 antibody response
SARS-CoV-2 peptide
SARS-CoV-2 peptides
SARS-CoV-2 proteome
Science
screened
sensitivity
Sequence conservation
sera
serological
Serological assay
severe acute respiratory syndrome Coronavirus
severe COVID-19
severe infections
severity
severity of COVID-19
specificity
Spike protein
stratified
strength
suggested
target
targets
tested
the antibody response
the SARS-CoV-2
the spike protein
Therapeutics
Therapies
two groups
understanding
Vaccine
Vaccines
Viral
virus
[DOI] 10.1126/science.abd4250 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1126/science.abd4250 PMC 바로가기 [Article Type] Research Article