Genome-Wide Association Mapping in Dogs Enables Identification of the Homeobox Gene, NKX2-8 , as a Genetic Component of Neural Tube Defects in Humans
개의 게놈 전반에 걸친 연관 매핑을 통해 인간의 신경관 결함의 유전적 구성 요소인 호메오박스 유전자 NKX2-8 식별 가능
Research Article
[키워드] addition
affected
Analysis
animal
animal models
Author
birth defects
Brain
canine
Care
caused
Central nervous system
chromosome
closure
codon
Combination
comparable
complex
component
condition
contribute
costly
defect
develop
disease
dog
during pregnancy
dysraphism
embryonic
ENCODE
environmental factors
etiology
Evidence
ExoN
exons
expected
explain
expressed
failure
found
frameshift
frameshift mutation
general term
Genes
Genetic
Genetic studies
genetics
Genome
genome-wide association
genomic region
home environment
Homeobox
Human
human population
human populations
humans
identification
identify
in addition to
interactions
lead
malformation
mapped
mapping
mechanism
Medical care
molecular basis
morbidity and mortality
multifactorial
Mutation
Neural
neural tube
Neural tube defect
Neural tube defects
NKX2
NKX2-8
NTD
NTDs
occur
pathology
Patient
performed
predicted
Pregnancy
premature stop codon
Protein
rare variant
Rare variants
receive
Regulatory
regulatory gene
reported
resulting
secondary to
sequenced
Sequencing
significantly
skin
Soft tissue
spina bifida
spinal cord
spinal dysraphism
Structure
Taking
tissue
tissues
tube
vertebral column
Weimaraner
[DOI] 10.1371/journal.pgen.1003646 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003646 PMC 바로가기 [Article Type] Research Article