Preventing Mortality in COVID-19 Patients: Which Cytokine to Target in a Raging Storm?Cell and Developmental Biology Published on 2020-07-172022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] acute respiratory syndrome blockade can be used chemokine Clinical efficacy clinical feature clinical trial Combination coronavirus Coronavirus disease 2019 COVID-19 COVID-19 mortality COVID-19 patient COVID-19 patients Critical Cytokine storm death Efficacy Factor hyperinflammatory cytokine storm IL-1 IL-6 IL-6 blockade ill patients immunopathological immunopathology Infection Inflammation Inflammatory inflammatory mediator Interpretation morbidity and mortality Mortality notable pathway Prevent Preventing SARS-CoV-2 Stage target targets Therapeutic strategies Treatment [DOI] 10.3389/fcell.2020.00677 PMC 바로가기 [Article Type] Cell and Developmental Biology
Coronavirus disease 2019 (COVID-19) pneumonia in a hemodialysis patient A case report4900 Published on 2020-07-022022-10-30 Journal: Medicine [Category] COVID-19, SARS, [키워드] 2019 novel coronavirus 2019 novel coronavirus disease absorbed Antibiotics antiviral drugs Atypical Blood purification cardiovascular disease Case report cause Clinical course Computed tomography Contact coronavirus Coronavirus disease 2019 Course COVID-19 COVID-2019 COVID-2019 patients CRRT diagnosed dialysis discharged disease dry cough End-stage renal disease ESRD Fever globe had no Hemodialysis hospital indicated inflammatory mediator Methylprednisolone MONITOR oxygen Patient patients patients with COVID-19 Pharyngeal swab Pneumonia polymerase chain positive PROTECT public health Pulmonary infection pulmonary inflammatory exudation renal replacement therapy RT-PCR RT-PCR assay SARS-CoV-2 significantly significantly more the patient Thorax treated Treatment uremia [DOI] 10.1097/MD.0000000000020956 PMC 바로가기 [Article Type] 4900
The Role of Interleukin-6 Inhibitors in the Treatment of COVID-19 Infections: A Case SeriesInternal Medicine Published on 2020-06-152022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress Administered China Clinical course clinical trial coronavirus coronavirus disease COVID 19 COVID-19 COVID-19 patient cytokine D-dimer levels effective ferritin level health emergency Healthcare systems Hydroxychloroquine hypoxemic Hypoxemic respiratory failure IMPROVE increase in Infection Inflammation Inflammatory marker inflammatory mediator inhibitors interleukin (il)-6 lactate dehydrogenase medication moderate morbidity and mortality Novel coronavirus outbreak oxygen saturation Pathogenesis pathophysiology Pneumonia Research Respiratory failure role SARS-CoV-2 Sery severe symptoms syndrome targeting the disease Tocilizumab Treatment World Health Organization worsened [DOI] 10.7759/cureus.8631 PMC 바로가기 [Article Type] Internal Medicine
Cerebral hemorrhage during the active phase of SARS-CoV-2 infection in a patient with amyloid angiopathy: case reportCase Report Published on 2020-01-012022-10-29 Journal: Revista Brasileira de Terapia Intensiva [Category] COVID-19, MERS, [키워드] amyloid angiopathy Angiopatia amiloide cerebral Case report causes cerebral Cerebral amyloid angiopathy cerebral hemorrhage change Coronavirus infections COVID-19 Critical care Cuidados críticos Cytokine storm described Endothelial dysfunction female greater Hemorragia cerebral hemorrhage Hypoxemia Infecções por Coronavirus inflammatory mediator intensive care units multifactorial neurological Patient SARS-CoV-2 SARS-COV-2 infection severity Unidades de terapia intensiva with COVID-19 [DOI] 10.5935/0103-507X.20200098 PMC 바로가기 [Article Type] Case Report
Rationale and design of the “Tocilizumab in patients with moderate to severe COVID-19: an open-label multicentre randomized controlled” trial (TOCIBRAS)"중등도에서 중증의 COVID-19 환자에 대한 토실리주맙: 공개 라벨 다기관 무작위 통제" 시험(TOCIBRAS)의 근거 및 설계Original Article Published on 2020-01-012022-08-13 Journal: Revista Brasileira de Terapia Intensiva [Category] 임상, [키워드] 7-point ordinal scale adjusted age and sex alleviate Analysis anti-inflammatory therapies Anti-inflammatory therapy applied approved Brazil C reactive protein Clinical outcome clinical outcomes clinical status combating consequence Coronavírus COVID-19 COVID-19 patient COVID-19 patients criteria D-dimer disease severity dissemination enrolment ethical committee Ethics ferritin IMPROVE inflammatory cascade inflammatory mediator Inflammatory response inhibiting institutional review board institutional review boards interleukin-6 International Lactate lactate dehydrogenase limit Local mediator moderate to severe multicentre National Odds ratio Open-label ordinal logistic regression Ordinal Scale outcome patients patients with COVID-19 patients with moderate primary endpoint Pro-inflammatory marker pro-inflammatory markers protocol Randomized Randomized controlled trial rationale required severe COVID-19 severity Standard of care Stratification Study protocol the disease The TOCIBRAS protocol TOCIBRAS Tocilizumab Tocilizumabe Trial trial testing variable [DOI] 10.5935/0103-507X.20200060 PMC 바로가기 [Article Type] Original Article
Mouse Hepatitis Virus Infection Upregulates Genes Involved in Innate Immune ResponsesResearch Article Published on 2014-10-312022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] activated Activation acute phase Affymetrix Analysis binding calcium ion caused CD11b CD19 CD4 CD52 CD68 CD74 CD8 Cell cellular changes in CNS contribute demonstrated Demyelination expression IFN-γ IL-12 increased expression induce Infection Inflammation inflammatory mediator Innate Local maturation mice microenvironment microglia morphology mouse mRNA expression myelin sheath phagocytosis regulate released response reveal robust significantly turn upregulated viral replication [DOI] 10.1371/journal.pone.0111351 PMC 바로가기 [Article Type] Research Article
Influence of bacteriophage P22 on the inflammatory mediator gene expression in chicken macrophage HD11 cells infected withSalmonellaTyphimurium살모넬라 타이푸리움에 감염된 닭 매크로포지 HD11 세포에서 박테리오파지 P22의 염증 매개체 유전자 발현에 미치는 영향journal-article Published on 2014-03-012024-07-31 Journal: FEMS Microbiology Letters [Category] 살모넬라증, [키워드] bacteriophage HD11 cell inflammatory mediator lysogeny Macrophage Salmonella Typhimurium [DOI] 10.1111/1574-6968.12379 [Article Type] journal-article