Informed consent – Page 8 – Communicable Diseases Research

Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients

중환자 코로나19 환자의 혈장 사이토카인 수치 증가 및 장기 부전 및 30일 사망률과의 상관관계

Article

Published on 2021-02-012022-09-11
Journal: Cytokine [Category] SARS, 바이오마커,

High-dose vitamin D versus placebo to prevent complications in COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial (CARED-TRIAL)

COVID-19 환자의 합병증을 예방하기 위한 고용량 비타민 D 대 위약: 무작위 대조 시험(CARED-TRIAL)을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-02-012022-09-10
Journal: Trials [Category] MERS, 임상,

[키워드] 1:1 24 hour 24 hours Admission age allergy ambient and vitamin D anticonvulsants assessment Asthma Blinding block Blood body mass body mass index breathing ambient air calcium cardiovascular cardiovascular disease carried charge childbearing childbearing age cholecalciferol chronic Chronic kidney disease clinical clinical complications clinical outcomes comparator Complete Complication computer-generated Contact COPD coronary artery bypass grafting country COVID-19 COVID-19 patient COVID-19 patients criteria current death diabete diabetes discharge discretion disease dissemination dose double-blind Effect element enrolled evaluate exclusion exclusion criteria failure first stage FIVE gel Gender grafting Haemodialysis High dose history hospital Hospital admission hospital discharge Hospitalization hypercalcemia hypertension IMPROVE include inclusion criteria Infection Informed consent initiated Intervention invasive invasive or non-invasive ventilation investigator investigator-initiated investigators Kidney disease Life expectancy liver malabsorption management matching placebo mechanical ventilation medication moderate multicentre Myocardial infarction Non-invasive non-invasive ventilation number objective occur Occurrence oral cholecalciferol oral intake Organ failure outcome oxygen oxygen saturation Oxygenation packaged pandemic PaO participant Patient patients performed Pharmacist pharmacological physiological effects Placebo placebo-controlled clinical trial Pneumonia Pragmatic Prevent Primary outcome protocol pulse oximetry random randomised randomised controlled trial randomization randomization ratio Randomized recorded recruited recruitment Registered reported Requirement researcher respiratory Respiratory outcome respiratory outcomes risk routine clinical practice RT-PCR Sample size sarcoidosis SARS-CoV-2 Sepsis sequence sequential design serum calcium Seven stages Standard status stratified study drug study medication Study protocol subject supplementary material total sample size Treatment Trial Trial registration Two-arm valve replacement variable Vitamin D Vitamin D supplementation was used website
[DOI] 10.1186/s13063-021-05073-3 PMC 바로가기 [Article Type] Letter

Homeopathy for Covid-19 in Primary Care: A structured summary of a study protocol for a randomized controlled trial

일차 진료에서 Covid-19에 대한 동종 요법: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-02-012022-08-31
Journal: Trials [Category] MERS, 임상, 치료제,

[키워드] 1:1 6 hour 6 hours acute respiratory syndrome Adverse adverse events alcohol alternative hypothesis appearance blinded Blinding block randomization bottle Brazil changed changes chest pain clinical trial cough COVID-19 defined dissemination dose double-blind Effectiveness elapsed element emergency services Fever followed by headache Home isolation homeopathic medicine homeopathic medicines Homeopathy hospitalizations identity Influenza Influenza-like symptoms Informed consent investigators measure medication Medicine Medicines Mild mild case mild cases muscle aches network null hypothesis number objective Older outcome Pain participant performed Placebo placebo-controlled positive RT-PCR primary care primary endpoint Primary Health Care protocol randomisation randomised Randomized Randomized controlled trial Randomized Controlled Trial protocol recorded Recovery time recruitment Registered required respiratory Sample size SARS-CoV-2 secondary Severe acute respiratory syndrome shakes sore throat statistician status study medication Study protocol submitted supplementary material Symptom Telemedicine Time to recovery tiredness treatment group Trial two group two groups Unified Health System university website without symptoms
[DOI] 10.1186/s13063-021-05071-5 PMC 바로가기 [Article Type] Letter

Telemedicine and the Use of Korean Medicine for Patients With COVID-19 in South Korea: Observational Study

한국의 COVID-19 환자에 대한 원격 진료와 한약 사용: 관찰 연구

Observational Study

Published on 2021-01-192022-08-31
Journal: JMIR Public Health and Surveillance [Category] 임상, 치료제,

[키워드] analyzed Appetite Care Chest chest tightness chills collected conducted COVID-19 COVID-19–related symptom COVID-19–related symptoms diarrhea dry cough Dyspnea fatigue guideline headache Health Health care system help herbal medicine herbal medicines Infectious disease information Informed consent Korea Korean Korean medicine loss of appetite medical service Medicine muscle pain nasal congestion objective operation overcome Pain pandemic participant participated Patient patients with COVID-19 Program provided reported Result rhinorrhea sore throat South South Korea Spread sputum telehealth Telemedicine Treatment Wuhan Wuhan, China
[DOI] 10.2196/20236 PMC 바로가기 [Article Type] Observational Study

Treatment of COVID-19 pneumonia with glucocorticoids (CORTIVID): a structured summary of a study protocol for a randomised controlled trial

글루코코르티코이드(CORTIVID)를 사용한 COVID-19 폐렴의 치료: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-01-112022-09-10
Journal: Trials [Category] 임상, 치료기술,

[키워드] absolute difference active cancer Admission age allergy ambient approved arterial blood Barcelona baseline biochemical Blinding Block randomisation block size Blood Breastfeeding C-reactive protein C-reactive protein (CRP candidate clinical Clinical outcome clinical outcomes clinical trial contraindication Control control group Controlled trial COVID-19 COVID-19 admission COVID-19 pneumonia criteria death decrease defined detect Deterioration Device diabete Diabetes Mellitus diagnosis of SARS-CoV-2 discretion dissemination drug drug treatment early treatment Effectiveness element elevated eligible emergency room ethics committee EudraCT exclusion criteria expected explained ferritin Follow-up followed by following glucocorticoid Glucocorticoids groups hospital Hospital admission hypertension ICU Identifier IL-6 immunosuppressants IMPROVE inclusion criteria independent Infection inflammatory biomarkers Informed consent intensive care intensive care unit interleukin interleukin-6 Intervention intervention group intravenous intravenous infusion Laboratory Loading dose Lopinavir Lopinavir/ritonavir maintenance dose management manic manic disorder mechanical ventilation Medical devices Medicine Medicines Methylprednisolone Nasopharyngeal swab nasopharyngeal swabs number objective outcome outcome assessor outcome assessors Outpatient oxygen oxygen saturation PaO parallel-group partial pressure Partial pressure of oxygen participant Patient patient age patients patients with COVID-19 Pharmacy Placebo Pneumonia polymerase chain Potential Pregnancy primary endpoint Primary outcome procalcitonin proportion protocol Psychiatric Psychological psychotic pulse Pulses Quadruple blind radiological random randomisation randomised randomised controlled trial randomizeR receive recommendation recruit recruitment Registered Remdesivir required researcher reverse transcriptase Reverse transcriptase polymerase chain reaction Ritonavir RT-PCR Sample size SARS-CoV-2 SARS-CoV-2 pneumonia sequence Spain Spanish sputum Standard of care status stratified study outcomes Study protocol supplementary material Symptom Tablet the patient therapy title total sample size transcriptase Treatment treatment failure Trial Trial registration two group two groups two-tailed type I type II error uncontrolled hypertension unit university Version website with COVID-19
[DOI] 10.1186/s13063-020-04999-4 PMC 바로가기 [Article Type] Letter

Diagnostic Accuracy of Electro-Chemiluminescence Immunoassay Anti-SARS-CoV-2 Serological Test

Allergy/Immunology

Published on 2021-01-092022-10-31
Journal: Cureus [Category] COVID-19,

Double-blind, randomized, controlled, trial to assess the efficacy of allogenic mesenchymal stromal cells in patients with acute respiratory distress syndrome due to COVID-19 (COVID-AT): A structured summary of a study protocol for a randomised controlled trial

COVID-19(COVID-AT)로 인한 급성 호흡 곤란 증후군 환자에서 동종 간엽 기질 세포의 효능을 평가하기 위한 이중 맹검, 무작위, 대조 시험: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-01-062022-09-10
Journal: Trials [Category] MERS, 바이오마커, 임상, 치료제,

[키워드] 1:1 24 hours 7-point ordinal scale acute respiratory distress acute respiratory distress syndrome Administered administration Admission Adult patient Adult patients Adverse Adverse drug reactions AEs age All trial participants all-cause mortality allergy Allogeneic ARDS assessment assigned baseline Biomarker blinded Blinding C-reactive protein carcinoma carcinoma in situ carried cellular chain change childbearing potential Chloroquine Clinical practice clinical status clinical trial coagulation test coagulation tests conducted Control control arm Course COVID COVID-19 CRF criteria CT scan cumulative incidence current Cytokines D-dimer Day death described determined by Diagnosis disease dissemination double-blind drug Duration ECMO Efficacy Efficacy and safety element eligible End endpoints enrolment EudraCT evaluate evaluate the effect event exclusion criteria Extracorporeal extracorporeal membrane oxygenation failure ferritin fibrosis FiO2 form GRADE grade 3 greater Haemodialysis handling hemofiltration history hospital Hospitalization hydroxy ICU ICU admission IMPROVE include inclusion criteria Informed consent intravenous Intravenous administration intravenous dose intubation Invasive mechanical ventilation invasive ventilation investigational medicinal product involved laboratory confirmation laboratory-confirmed SARS-CoV-2 infection lactation LDH less Level Local Lopinavir Lopinavir/ritonavir lung disorder lymphocyte marker Mechanical mechanical ventilation Medicine Medicines Mesenchymal stromal cells moderate to severe Mortality MSC negative pregnancy test neoplasm neutrophil neutrophil counts Non-invasive number objective occur off-label opinion Ordinal Scale organ oropharyngeal swab oropharyngeal swabs Other outcome oxygen oxygen saturation Oxygen therapy PaO2 PaO2/FiO2 ratio parameters participant Patient PCR percentage Placebo polymerase chain reaction Pregnancy primary endpoint product Production profile progression protocol Pulmonary embolism pulmonary fibrosis Pulmonary function tests randomised randomised controlled trial randomization Randomized Randomly Rapid antigen tests reaction receive recruitment Registered Remdesivir report respiratory Respiratory distress syndrome Resuscitation Ritonavir SAEs Sample size SARS-COV-2 infection secondary Secondary endpoints Sequential Organ Failure Assessment Serious Adverse Events SOFA Spain specificity specimen Sponsor Standard of care status stromal cell stromal cells Study protocol subpopulations supplemental oxygen supplementary material syndrome the cell the disease the patient the primary endpoint the WHO time Tocilizumab Tolerability Treatment treatment arm treatment for COVID-19 treatment group Treatment protocol Trial trial participant Trial registration unit website women worldwide pandemic written consent
[DOI] 10.1186/s13063-020-04964-1 PMC 바로가기 [Article Type] Letter

Rehabilitation Exercise and psycholoGical support After covid-19 InfectioN’ (REGAIN): a structured summary of a study protocol for a randomised controlled trial

재활 운동 및 심리적 지원 After covid-19 Infection'(REGAIN): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-01-062022-09-10
Journal: Trials [Category] MERS, 임상,

[키워드] 1:1 age allocation concealment anticipated anxiety symptoms assessment automatically baseline Bengali best blind Blinding Care clinical clinically Cognitive function Complete computer-generated Controlled trial COVID-19 COVID-19 infection Critical care current death defined depressive determine dissemination Dyspnoea eight element email engage Engagement English exclusion criteria exercise Group allocation Health health economic evaluation health problems hospital hospital care hospital discharge include Informed consent life mental health mental health problem mental health problems NHS number objective Online outcome parallel group participant performed physical physical activity Physical health Post-traumatic stress disorder Practitioner Primary outcome profile protocol psychological support PTSD Quality of life questionnaire randomisation randomised randomised controlled trial rehabilitation Rehabilitation Exercise reported resource Sample size secondary Secondary outcomes sequence Standard status stratified Study protocol Support supported symptom severity Treatment Urdu usual care utility ventilatory ventilatory support Version web-based system website
[DOI] 10.1186/s13063-020-04978-9 PMC 바로가기 [Article Type] Letter

Virucidal effect of povidone iodine on COVID-19 in the nasopharynx: A structured summary of a study protocol for an open-label randomized clinical trial

비인두에서 COVID-19에 대한 포비돈 요오드의 바이러스 살균 효과: 공개 라벨 무작위 임상 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-01-042022-09-10
Journal: Trials [Category] 임상,

[키워드] 6 hour 6 hours acute renal failure adverse effect adverse effects adverse event adverse events anticipated Arm-1 ARMS assigned baseline being randomized Blinding both groups chronic renal failure clinical trial college comparator Concentration conducted confirmed case COVID-19 COVID-19 case COVID-19 virus creatinine criteria Data analysis diagnosed diet disease dissemination distilled water DMC Efficacy element eligibility assessment estimated glomerular filtration rate evaluate exclusion filtration rate Final glomerular filtration rate groups Identifier in both groups include Inclusion inclusion criteria independent Informed consent Intervention intervention arm intervention arms intervention group invasive involved Iodine KDIGO lactating masking Microsoft Excel Modification nasal Nasal Irrigation Nasal spray nasopharynx Noninvasive ventilation number objective Occurrence Open-label Other outcome parallel-group participant Patient performed Placebo positive Povidone Iodine pregnant women Primary outcome proportion protocol random number generation randomization Randomized randomized clinical trial RCT receive recruited Registered renal renal disease renal failure required routine care Sample size screened sealed secondary outcome sensitivity Seven single-center Stage statistician status Study protocol supplementary material Symptom Thyroid thyroid disease Trial trial protocol Trial registration Version virucidal virus website
[DOI] 10.1186/s13063-020-04963-2 PMC 바로가기 [Article Type] Letter

The efficacy and safety of Ivermectin in patients with mild and moderate COVID-19: A structured summary of a study protocol for a randomized controlled trial

경증 및 중등도 COVID-19 환자에서 이버멕틴의 효능 및 안전성: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Letter

Published on 2021-01-042022-09-10
Journal: Trials [Category] 임상, 치료제,

[키워드] 1:1 ACE inhibitor ACE inhibitors acute respiratory syndrome Adverse drug reaction Adverse drug reactions AIDS allergy anticipated Anticoagulant Anticoagulants Asthma Bandar Abbas Blinding Breastfeeding Captopril chest X-ray clinical clinical symptom Clinical symptoms clinical trial clinical trials company Computed tomography Confirmed Control control group control groups Controlled trial COVID-19 COVID-19 symptom criteria Critical CXR Department discharge Diseases dissemination dose Drug allergy education Efficacy and safety element evaluate exclusion criteria FIVE France group groups history Hospital stay Hospitalization Hospitalization Mechanical ventilation hydroxychloroquine sulfate ICU admission incidence include inclusion criteria India Infection Informed consent Inpatients Interferon beta-1a intervention group Iran Ivermectin Kidney disease liver loiasis Lopinavir Lopinavir/ritonavir mechanical ventilation Mild mild COVID-19 symptom mild COVID-19 symptoms mild pneumonia Ministry of Health moderate Moderate COVID-19 moderately severe COVID-19 MSD number objective Open-label Other outcome Outpatient outpatients parallel-group participant Patient patients patients with moderate PCR pharmaceutical Pharmaceutical Company Phase 3 Pneumonia Pregnancy Primary outcome Primary outcomes protocol random randomization Randomized Randomized controlled trial receive regimen Registered registration date registration number registry respiratory Ritonavir routine care Sample size secondary outcome selected Seven Severe acute respiratory syndrome single dose single-center standard treatment status Study protocol subsequent supplementary material table the patient Treatment treatment group Trial registration twice a day two group two groups underlying diseases Version Warfarin website weight
[DOI] 10.1186/s13063-020-04988-7 PMC 바로가기 [Article Type] Letter