inhibitory – Page 8 – Communicable Diseases Research

Intolerance of uncertainty predicts fear of healthcare settings but not desire for testing during the novel coronavirus pandemic

Research

Published on 2021-12-202022-11-01
Journal: Discover Psychology [Category] COVID-19,

Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)

Article

Published on 2021-12-082022-10-30
Journal: Molecules [Category] COVID-19, SARS,

Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors

강력한 SARS-CoV-2 주요 단백질분해효소 억제제로서의 주글론 및 그 유도체의 발견

Article

Published on 2021-12-052022-09-11
Journal: European journal of medicinal chemistry [Category] MERS, SARS, 신약개발, 진단,

[키워드] acetyl active site Amino acid amino acid residue Analysis antiviral activity caused Characteristics characterized Concentration concentrations contributed coronavirus COVID-19 demonstrated derivative Drug discovery Efficacy enzyme evaluated exhibited Host host cells hydrogen Hydrogen bond hydrogen bonds hydrolysis in vitro ingredient inhibit inhibitor inhibitors inhibitory inhibitory activity Juglone M pro M(pro) inhibitors molecular docking studies much higher naphthoquinone Naphthoquinones non-toxic outbreak peptide polyprotein positive control positive-sense single-stranded RNA protease proteinase Replication replication of SARS-CoV-2 Research RNA coronavirus SARS SARS-CoV-2 significantly suppress tested Transcription Vero E6 Vero E6 cell VERO E6 cells Viral virus
[DOI] 10.1016/j.ejmech.2021.113789 PMC 바로가기 [Article Type] Article

Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage

COVID-19 환자의 단일 세포 및 벌크 RNaseQ 프로파일 링은 감염에 의한 장기 손상의 면역 및 염증 메커니즘을 나타냅니다.

Article

Published on 2021-12-022022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

[키워드] accounted Analysis analyzed cardiac hypertrophy correlated COVID-19 COVID-19 infection COVID-19 organ damage COVID-19 patients gene expression Critical Cytokines damage deleterious effect determine downregulated downstream Effect effective Effectiveness eIF2 eukaryotic eukaryotic initiation factor 2 fibrosis Host host protein host proteins hypercytokinemia hypertrophy IL-17A IL-2 IL-6 IL-8 immune and inflammatory mechanisms of COVID-19 imperative induce Inflammation Inflammatory inflammatory genes inhibitors inhibitory initiation factor innate immune response Interaction interleukin investigation lead lung Lungs mechanism Mild moderate multiple organ failure NF-κB organ Organ failure organ injury organs overactive pathway Pathways patients peptide peptides potential therapeutic target potential therapeutic targets pro-inflammatory cytokine pro-inflammatory cytokines Profiling reduced RNAseq SARS-CoV-2 SARS-CoV-2 virus severe and critical patients severely infected patients Severity of infection single and bulk RNASeq cell profiling and analysis single-cell Stimulation suppress suppression therapeutic targets tissues translation Treatment upregulation Viral viral infection Viral protein Viral proteins viral-host protein was increased
[DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article

A single dose of SARS-CoV-2 FINLAY-FR-1A vaccine enhances neutralization response in COVID-19 convalescents, with a very good safety profile: An open-label phase 1 clinical trial

Research article

Published on 2021-12-012022-10-05
Journal: The Lancet Regional Health - Americas [Category] 유전자 메커니즘, 임상,

[키워드] adverse event Anti-RBD antibody Antibody titre Asymptomatic baseline booster cellular response clinical clinical trial convalescent COVID-19 Cuba dimeric elicited ELISA ENhance Environment evaluated finding funding greater Humoral response IFN-γ IgG increase in individual inhibitory Intramuscular injection Local median Mild minor natural immunity neutralization Open-label Partial Participants PCR-positive Primary outcome producing Public reactogenicity Receptor binding domain registry Reinfection reported safety profile SARS-CoV-2 Science secondary outcome Serious Adverse Event single dose subclinical infection T cell technology TNF-α vaccination Vaccine vaccine immunogenicity Virus neutralization titre
[DOI] 10.1016/j.lana.2021.100079 [Article Type] Research article

SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein

SARS-CoV-2는 스파이크 단백질을 통해 뇌 혈관주위세포의 면역 기능과 면역 기능을 완화합니다.

Article

Published on 2021-12-012022-09-11
Journal: Neurobiology of disease [Category] SARS, 유전자 메커니즘,

[키워드] accompanied accumulated ACE2 ACE2 expression acquisition Actin Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays binding Brain brain damage calcium cause caused cerebrovascular cerebrovascular disorders change characterized collagen Comorbidity contractile coronavirus disease coronavirus disease 19 Coronavirus-2 COVID-19 COVID-19 pathogenesis Cytokines deregulated develop disorder enzyme exacerbate Express expressing expression Fibronectin fluctuations function functional homolog host cell host cells human ACE2 Human brain hypoxia immune Immune cell immune function immune reaction impair infect infection with SARS-CoV-2 Inflammation inhibitory intranasal involved lipid peroxidation locus Macrophage mechanism mechanisms mice MIF Migration morphology Myofibrogenic transition nasal mucosa Neurological disorder Neurological disorders Neurovascular Neurovascular interface NF-κB NOTCH3 nuclear oxidative pericyte pericytes phenotypic pro-inflammatory cytokine pro-inflammatory cytokines promoted Protein Proteins provide reached reactivity receptor recognize Regulatory Respiratory illness S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S protein. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown signaling pathway spike Stress therapeutic interventions transgenic mice translated transmembrane triggered Vascular viral spike was increased
[DOI] 10.1016/j.nbd.2021.105561 PMC 바로가기 [Article Type] Article

Sanguiins—Promising Molecules with Broad Biological Potential

Review

Published on 2021-11-302022-10-29
Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS,

The Roles of Gasdermin D in Coronavirus Infection and Evasion

Microbiology

Published on 2021-11-262022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

Single-Cell Immunogenomic Approach Identified SARS-CoV-2 Protective Immune Signatures in Asymptomatic Direct Contacts of COVID-19 Cases

COVID-19 사례의 무증상 직접 접촉에서 SARS-CoV-2 보호 면역 서명을 식별한 단일 세포 면역유전체학적 접근 방식

Immunology

Published on 2021-11-252022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response amplitude antibody Antibody titer Asymptomatic B-cell BCR CD4 CD8 Cell characterized class close contact colony stimulating factor concomitant increase Contact controls coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 cytokine cytokine levels Cytokines direct contact Direct Contacts Eotaxin G-CSF granulocyte granulocyte-colony stimulating factor host immunity Identified IL-7 impacted infected cases infected patients Inflammatory inhibitory interleukin Macrophage memory memory B cell memory B cells MIF Migration MIP-1α naïve T cells Neutralizing Patient patients Profiling proportion receptor reported respiratory RNA SARS-CoV-2 scBCR-seq scRNA-seq scTCR-seq Sequencing severe acute respiratory syndrome Coronavirus shown signature significant increase single-cell status T cell T cells T-cell receptor TCR Temra cells virus Virus neutralization
[DOI] 10.3389/fimmu.2021.733539 PMC 바로가기 [Article Type] Immunology

In Covid-19 Infection, Plasma Extracellular Vesicle Tissue Factor Activity Does Not Correlate with D-Dimer Levels

Conference abstract

Published on 2021-11-232022-10-05
Journal: Blood [Category] 바이오마커,

[키워드] absence Activation activities activity acute respiratory syndrome Admission affected Analysis analyzed antibody Anticoagulant Antigen assays Biomarker Blood Cell circulating Coagulation Coagulopathies collected complex conducted Contact contribute corn correlation Cytokines D-dimer D-dimer level damaged disease disease severity dissociate download elevated evaluate expression extrinsic Factor fatality figure generate group healthy healthy control heparins highest Hospitalization hospitalized patient identify increase increase in induce Infection inhibitor inhibitory intensive care intrinsic Level mechanical ventilation mechanism Microparticle Mortality Neutrophil extracellular trap nucleic acid occur occurred organized outcome outcomes parameter pathway Patient performed plasma plasma samples positive patient processed procoagulant activity reduced released reported responsible SARS-CoV-2 selective severity shown significant difference the disease thrombin thrombosis tissue Treatment Trigger trypsin Variability Vesicle were measured while
[DOI] 10.1182/blood-2021-153142 [Article Type] Conference abstract