Expression profiles revealed potential kidney injury caused by SARS-CoV-2: a systematic analysis of ACE2 and clinical lessons learned from this discovery발현 프로필은 SARS-CoV-2로 인한 잠재적인 신장 손상을 나타냈습니다: ACE2의 체계적인 분석 및 이 발견에서 얻은 임상 교훈Research Paper Published on 2021-04-302022-09-10 Journal: Aging (Albany NY) [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 ACE2 distribution ACE2 expression ACE2-positive cell ACE2-positive cells acute renal failure Admission Adults Analysis analyzed assessment assessments Blood urea nitrogen cause caused Cell city Clinical findings collected Collecting duct Comorbidities conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 positive patient creatinine Data analysis dataset EGFR elevated epithelial cells estimated glomerular filtration rate Evidence female filtration rate functions glomerular glomerular filtration rate healthy individuals hospital induce Infection infection site kidney kidney damage Kidney function Kidney injury kidney tissue Laboratory laboratory findings males nitrogen novel Novel coronavirus novel coronavirus disease organ organs pathophysiology Patient patients Pneumonia positive cells profile renal failure renal function reported retrospective RNAseq RNAseq data SARS-CoV-2 scRNA-seq data selected sequencing data serum creatinine single-cell Single-cell RNA sequencing systematic analysis the patient the SARS-CoV-2 Transcriptome transcriptome analysis urea urea nitrogen viral loads Wuhan Wuhan, China [DOI] 10.18632/aging.202224 PMC 바로가기 [Article Type] Research Paper
Sensors for the detection of ammonia as a potential biomarker for health screeningArticle Published on 2021-03-302022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] acetone Biomarker Blood urea nitrogen breath Chemical engineering Chronic kidney disease CKD Complication Concentration condition conditions COVID-19 demonstrated detect detection system elevated Health Kidney function kidneys Limited liver medium Non-invasive platform protocol resulting selective sensor Sensors and biosensors thermodynamic urea [DOI] 10.1038/s41598-021-86686-1 PMC 바로가기 [Article Type] Article
The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trialCOVID-19 중증 환자의 임상 및 생화학적 매개변수에 대한 오메가-3 지방산 보충제의 효과: 무작위 임상 시험Randomized Controlled Trial Published on 2021-03-292022-08-13 Journal: Journal of Translational Medicine [Category] SARS, 바이오마커, 임상, [키워드] albumin arterial pH arterial pressure assigned base excess baseline Bicarbonate biochemical marker biochemical parameter Blood cells blood glucose Blood urea nitrogen calcium carbon dioxide clinical clinical study clinical trials collected Coma conducted control group coronavirus creatinine Critically ill Critically ill patient critically ill patients Date double-blind Effect fatty Fatty acid fatty acids fortified Glasgow coma scale Glucose groups HCO HCT hematocrit hemoglobin immune system infected with COVID-19 Inflammatory inflammatory and biochemical markers Intervention intervention group Kidney function mean arterial pressure n3-PUFA n3-PUFAs name nitrogen no significant difference no significant differences O2sat omega-3 Omega-3 fatty acids Omega-3 polyunsaturated fatty acids omega-3 supplementation oxygen parameter partial pressure Partial pressure of oxygen partial thromboplastin time Patient phosphorus Platelet Plt Polyunsaturated Potassium randomized clinical trial Randomly Registered Registration registration number registry renal function respiratory and renal function Respiratory function Result scale significant differences significantly higher sodium survival rate THROMBOPLASTIN Trial two groups urea viral infections WBCs White blood cell White blood cells with COVID-19 [DOI] 10.1186/s12967-021-02795-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Survival Analysis and Risk Factors in COVID-19 PatientsOriginal Research Published on 2021-03-252022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, [키워드] 2019 coronavirus disease age Analysis analyzed AUC Blood urea nitrogen C-reactive protein categorical variable Characteristics chi-square test clinical Clinical characteristics clinician collected Comorbidities continuous variable COVID-19 death death group diagnosed with COVID-19 evaluate Factor Fisher’s exact test groups help hemoglobin higher risk independent indicated Kidney function laboratory parameter lactate dehydrogenase liver lymphocyte Lymphocyte count lymphocyte counts management medical records neutrophil count outcome Patient patients patients with COVID-19 Platelet Prognosis progression Regression model renal dysfunction risk risk factor risk factors of death serum albumin statistically significant survival survival probability tested Treatment was used White blood cell [DOI] 10.1017/dmp.2021.82 PMC 바로가기 [Article Type] Original Research
Acute kidney injury and mortality risk in older adults with COVID-19Observational Study Published on 2021-03-222022-10-04 Journal: Journal of Nephrology [Category] MERS, 임상, [키워드] 95% CI 95% confidence interval Acute kidney injury adjusted adverse outcome AKI baseline C reactive protein clinics COVID-19 CRP diagnoses evaluated examined glomerular filtration rate highest Hospitalized In-hospital death incidence initial Kidney function Kidney injury Logistic regression mortality risk Non-COVID-19 observational study occurred Older Older adults older patient outcome Patient patients hospitalized patients with COVID-19 patients without COVID-19 reduced Result risk risk factor supplementary material with COVID-19 [DOI] 10.1007/s40620-021-01022-0 PMC 바로가기 [Article Type] Observational Study
Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19Research Published on 2021-03-102022-10-29 Journal: JAMA Network Open [Category] COVID-19, SARS, [키워드] 95% CI Acute kidney injury adjusted adjusted hazard ratio AKI assessment association baseline black Chronic kidney disease cohort study Comorbidities Comorbidity conducted Connecticut coronavirus disease COVID-19 creatinine declined decrease dialysis discharge Effect exposure faster finding Follow-up function glomerular filtration glomerular filtration rate greater greater decrease Hispanic hospital hospital discharge Hospitalization hypertension Importance In-hospital independent interquartile range Intervention kidney Kidney disease Kidney function Kidney injury limit longitudinal measure median age objective occur participant Patient patients hospitalized patients with AKI patients without COVID-19 Point Relevance Result retrospective cohort study returned Rhode Island screened secondary outcome setting severity subgroup of patient tested those who survived trajectory were used with COVID-19 women [DOI] 10.1001/jamanetworkopen.2021.1095 PMC 바로가기 [Article Type] Research
The association between perceived stress with sleep quality, insomnia, anxiety and depression in kidney transplant recipients during Covid-19 pandemicResearch Article Published on 2021-03-082022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] age Analysis Anxiety association caused Compliance Depression enrolled independent index Infection Insomnia Intervention investigated ISI Kidney function kidney transplant recipient kidney transplant recipients laboratory data material men not significant outbreak pandemic Patient patients Perceived stress performed positively correlated problem PROTECT PSS psychiatric disorder Psychological distress Quality recorded Regression rejection Result scale significantly higher Sleep Sleep disturbance sleep quality Stress Stress Scale the patient Treatment [DOI] 10.1371/journal.pone.0248117 PMC 바로가기 [Article Type] Research Article
Outcomes Among Patients Hospitalized With COVID-19 and Acute Kidney InjuryObservational Study Published on 2021-02-012022-10-05 Journal: American journal of kidney diseases : the official [Category] SARS, 임상, [키워드] Acute kidney injury Acute kidney injury (AKI) acute renal failure acute renal failure (ARF) acute respiratory syndrome adjusted AKI AKI-on-CKD Chronic kidney disease cohort study comorbid conditions coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 outcomes COVID-19 pandemic death demographics dialysis discharge greater hospital hospital discharge Hospitalization Hospitalized hospitalized patient Illness severity In-hospital In-hospital death in-hospital mortality incidence rate independent risk factor kidney Kidney function kidney replacement therapy (KRT) Logistic regression multivariable New York outcome Patient patients patients hospitalized patients with AKI patients without AKI rationale receiving recovery remained renal renal prognosis Renal recovery Retrospective study risk SARS-CoV-2 secondary setting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Stage survival survived Taking therapy time-to-event analysis with COVID-19 [DOI] 10.1053/j.ajkd.2020.09.002 PMC 바로가기 [Article Type] Observational Study
Comparative Evaluation of the Treatment of COVID-19 with Multicriteria Decision-Making Techniques다기준 의사결정 기법을 통한 코로나19 치료의 비교 평가Comparative Study Published on 2021-01-222022-09-10 Journal: Journal of Healthcare Engineering [Category] 진단, 치료제, [키워드] addition administration age alternatives Analysis applied assigned Comparative complex coronavirus disease Coronavirus disease 2019 COVID-19 criteria drug effective evaluate evaluated Favipiravir Fever followed by FPV global pandemic healthcare Hydroxychloroquine Immunoglobulin include interleukin Intravenous immunoglobulin IVIG Kidney function Lopinavir Lopinavir/ritonavir management New objective outbreak plasma plasma exchange Pregnancy problem qualitative data Quantitative reported Result Ritonavir Side effects technique the disease to define Treatment treatment methods [DOI] 10.1155/2021/8864522 PMC 바로가기 [Article Type] Comparative Study
Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19SARS-CoV-2 수용체 ACE2 활성 수준은 대동맥 협착증이 있는 고령 환자에서 매우 높아집니다. COVID-19의 중증도에 대한 바이오마커로서의 ACE2의 의미Original Article Published on 2021-01-202022-09-11 Journal: GeroScience [Category] MERS, 바이오마커, [키워드] ACE2 ACE2 activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Aortic stenosis Biomarker blood pressure cardiovascular complication cardiovascular complications cardiovascular disease cardiovascular diseases cellular receptor chronic inflammation circulating Clinical data coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlated COVID-19 COVID-19 mortality COVID-19 susceptibility CRP drug Ejection fraction elderly Elderly patient elderly patients elevated flow velocity functions GFR healthy individual healthy individuals high mortality higher risk hypertension hypertensive implication independent independent of inflammatory state inhibitor inhibitory Kidney function left ventricular ejection fraction Level no effect Older Patient patients RAAS receptor ACE2 respiratory SARS-CoV-2 SARS-CoV-2 susceptibility serum severe acute respiratory syndrome Coronavirus severity of COVID-19 Support systolic pressure TAPSE the SARS-CoV-2 ventricular ventricular ejection were measured [DOI] 10.1007/s11357-020-00300-2 PMC 바로가기 [Article Type] Original Article