Improved HPLC method for the determination of ribavirin concentration in red blood cells and its application in patients with COVID-19적혈구 내 리바비린 농도 측정을 위한 개선된 HPLC 방법 및 COVID-19 환자에 대한 적용Article Published on 2022-07-012022-09-11 Journal: Biomedical chromatography : BMC [Category] 치료제, [키워드] addition Adverse drug reactions Anemia antiviral drug Blood changes in Concentration correlation coefficient COVID-19 declined determine Efficacy erythrocyte hematocrit hematological parameter hematological parameters hemoglobin HPLC Improved Interim linear lowest Patient patients with COVID-19 phosphatase phosphorylated ranged red blood cell red blood cells ribavirin synthetic the patient [DOI] 10.1002/bmc.5370 PMC 바로가기 [Article Type] Article
Antibody responses and risk factors associated with impaired immunological outcomes following two doses of BNT162b2 COVID-19 vaccination in patients with chronic pulmonary diseases만성 폐질환 환자에서 BNT162b2 COVID-19 백신 2회 접종 후 손상된 면역학적 결과와 관련된 항체 반응 및 위험 인자Article Published on 2022-07-012022-09-12 Journal: BMJ Open Respiratory Research [Category] MERS, 진단, [키워드] 1:1 1.26 95% CI adjusted antibody concentration Antibody Response aRR association Asthma bronchiectasis Charlson Comorbidity Index chronic pulmonary disease cohort study Comorbidity Control controls copd epidemiology COVID-19 COVID-19 vaccination COVID-19 vaccine defined dose Factor fibrosis first vaccination functional geometric healthcare personnel Humoral response identify immunological immunological responses Immunosuppression immunosuppressive Inclusion increasing age Interaction interstitial Interstitial Fibrosis lowest mRNA neutralising neutralising antibody of BNT162b2 outcome Patient Poisson regression Prednisolone Primary outcome Prospective quartile Receptor binding domain reported Responder response responses risk risk factor secondary outcome tested vaccination [DOI] 10.1136/bmjresp-2022-001268 PMC 바로가기 [Article Type] Article
World Hypertension Day 2021 in Italy: Results of a Nationwide Survey2021년 세계 고혈압의 날 이탈리아: 전국 설문조사 결과Article Published on 2022-07-012022-09-12 Journal: High blood pressure & cardiovascular prevention : [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Administered age antihypertensive medication Awareness blood pressure cardiovascular disease cardiovascular risk Clinical practice conducted cross-sectional Day death employment feature highest hypertension individual Italian lowest medications participant Patient provide questionnaire raise reduction Result SARS-CoV-2 pandemic Sex Society standard procedure subset survey therapeutic therapeutic alliance treated Treatment uncontrolled hypertension was measured [DOI] 10.1007/s40292-022-00519-4 PMC 바로가기 [Article Type] Article
Breast reconstruction during the COVID-19 pandemic: Single institution experience from the pandemic’s epicenter in the United StatesCOVID-19 대유행 중 유방 재건: 미국의 대유행 진원지에서 단일 기관 경험Article Published on 2022-07-012022-09-11 Journal: Medicina [Category] COVID19(2023년), SARS, 변종, [키워드] analyzed autologous Breast Breast cancer Breast reconstruction Cancer screening Care changed changes in conducted coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 pandemic declined Delta determine effort increase in lowest mammography New York City omicron pandemic performed reconstruction reduced retrospective Screening subsequent summer surgical surgical treatment Surveillance the United State track Treatment variants Volume while [DOI] 10.1016/j.bjps.2022.02.021 PMC 바로가기 [Article Type] Article
Mortality Due to COVID-19 in Renal Transplant Recipients, Related to Variants of SARS-CoV-2 and Vaccination in MexicoArticle Published on 2022-07-012022-11-16 Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 변종, [키워드] Combination coronavirus country COVID-19 death determine dose General population greater highest infected with COVID-19 information kidney kidney transplant kidney transplant recipients less lowest mRNA vaccine National omicron pandemic Patient patients recipient recommendations reduce SARS-CoV-2 SARS-COV-2 infection shown Transplant vaccination variant variants vector [DOI] 10.1016/j.transproceed.2022.05.010 PMC 바로가기
Immunoassay platform with surface-enhanced resonance Raman scattering for detecting trace levels of SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 미량 수준을 검출하기 위한 표면 강화 공명 라만 산란 기능이 있는 면역 분석 플랫폼Article Published on 2022-07-012022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술, [키워드] aggregation antibody coated with comparable Concentration conjugation Conjugation in gold nanoparticles coronavirus disease COVID-19 COVID-19 patient COVID-19 patients disease early diagnosis genetic material gold Gold nanoparticle immunoassay lack limit of detection lowest Methylene Methylene blue multidimensional onset of symptoms plasma platform prevented Protein Resonant Raman molecules SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike protein detection scattering SERRS immunoassay Platform silica Silica shell functionalization. Spike protein Support the immunoassay Viral proteins [DOI] 10.1016/j.talanta.2022.123381 PMC 바로가기 [Article Type] Article
Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized With COVID-19: A Blinded, Randomized, Placebo-Controlled TrialRandomized Controlled Trial Published on 2022-07-012022-10-05 Journal: Chest [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] 28-day mortality activity acute respiratory symptom adjusted odds ratio adults hospitalized analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody assigned blinded clinical clinical status clinical trial convalescent plasma convalescent plasma group COVID-19 death died discharged Efficacy groups highest hospital Illness severity improve clinical outcomes lowest multicenter multivariable Neutralizing not differ outcome outcomes passive immunity Patient Placebo placebo group placebo-controlled plasma primary analysis Primary outcome randomization randomized clinical trial randomized patients Randomly receive Registration Regression model Result SARS-CoV-2 SARS-COV-2 infection Secondary analyses selected seronegative seven-category ordinal scale stratified supported the placebo group Treatment treatments for COVID-19 Trial trial participant with COVID-19 [DOI] 10.1016/j.chest.2022.06.029 [Article Type] Randomized Controlled Trial
Impact of previous exposure to SARS-CoV-2 and of S-Trimer (SCB-2019) COVID-19 vaccination on the risk of reinfection: a randomised, double-blinded, placebo-controlled, phase 2 and 3 trialSARS-CoV-2 및 S-Trimer(SCB-2019) COVID-19 백신에 대한 이전 노출이 재감염 위험에 미치는 영향: 무작위 배정, 이중 맹검, 위약 대조, 2상 및 3상 시험Clinical Trial Published on 2022-07-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] 1:1 95% CI addition Alpha assigned attack rates B.1.1.7 B.1.351 B.1.617.2 B.1.621 baseline Beta calculate CEPI Clover Coalition confirmed case COVID-19 COVID-19 infection COVID-19 vaccination COVID-19 vaccine dose double-blind double-blinded Efficacy enrolled Evidence evidence of exposure to FIVE groups hospitalisation Impact injection site pain Innovation IQVIA Lambda Local lowest moderate-to-severe COVID-19 multicentre no evidence of P.1 participant Participants Phase 2 Placebo placebo-controlled placebo-controlled trial Primary outcome Primary outcomes protection Protective randomised Randomly Rate reactogenicity Real-time PCR receive recipients recombinant Reinfection reported response risk SARS-CoV-2 SARS-CoV-2-naïve participants SCB-2019 Secondary analyses secondary analysis Serious Adverse Event Serious Adverse Events severe adverse events severe COVID-19 severity subsequent subset symptomatic systemic adverse event systemic adverse events technology Trial USA vaccination Vaccine vaccine dose vaccine efficacy variant variants Viral variants with COVID-19 [DOI] 10.1016/S1473-3099(22)00144-X PMC 바로가기 [Article Type] Clinical Trial
In silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19 Research Published on 2022-07-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료기술, 치료법, 치료제, [키워드] Acidic Analysis antiviral activity aromatic group average binding affinities binding affinity binding free energy binding interaction Ceftazidime Cell Compound coronavirus COVID-19 demonstrated docking exceptional exhibited FIVE fraction functional greater groups Health high stability HPLC Hydrogen bond in silico in vitro study Interaction less lowest MD simulation Molecular dynamics simulation occurred oxygen pandemic penetration Potential treatment predict Protein RBD RBD residue Receptor binding domain required retained SARS-CoV-2 SARS-CoV-2 viral selected similarity suggested the RBD the SARS-CoV-2 these compound Toxicity Treatment [DOI] 10.1038/s41598-022-15288-2 [Article Type] Research
Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis2021년 11월 14일까지 SARS-CoV-2의 전 세계, 지역 및 국가 일일 및 누적 감염 추정: 통계 분석Article Published on 2022-06-252022-09-11 Journal: Lancet (London, England) [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] accounted adjusted Analysis antibody approach Asia assumption available data B.1.1.529 Baltimore calculated Complete country COVID-19 COVID-19 research cumulative database death deaths determinant determinants distribution effective estimate excess mortality foundation future infection help herd immunity Herd immunity threshold highest Hospital admissions hospitalisation hospitalisations identify IFR IHR Immunity India individual individuals Infection infection rate infection rates infections infectious infectiousness information Johns Hopkins Johns Hopkins University location lowest Melinda Gate Melinda Gates Mortality National occurred Oceania pandemic parameter peaking per day Population predict predictor produced proportion Reinfection reported Reporting reproductive responses risk robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sensitivity seroprevalence survey Seven statistical statistical analysis statistical model sub-Saharan Africa susceptibility systematic reviews These data transmission patterns USA Vaccinations Vaccine variant variants [DOI] 10.1016/S0140-6736(22)00484-6 PMC 바로가기 [Article Type] Article