mediator – Page 8 – Communicable Diseases Research

Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans

기능적 다양화는 칸디다 알비칸스에서 MED2 상동체의 유전자 패밀리 확장을 수반합니다

Research Article

Published on 2018-04-092022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 3’ end accompany addressed affected aggregation biological function Biological functions buffer Candida Candida albican Candida albicans Cell Combination commensal complex component conserved contribute contributed correlated did not produce difficulty domain duplication Effect entire gene example expansion expression facilitate family members function functional functions Gene duplication gene families gene family generate Genes genetic diversity greater growth homolog identify INDEL individual gene individual genes induced Infection influence involved killing Macrophage mapped mechanism mediator Mutation natural selection neofunctionalization occurred opportunistic pathogen organism overlap pathogen pathogenic phenotype Phenotypes phenotypic phenotypic effect polymorphic site Positive selection promoter provide question regulate regulated Regulation Regulatory repeated selective pressure sequence sequence similarity Specific strain Strains subfunctionalization subunit sucrose traits transcriptional transcriptional regulator unique Variability variant virulence were assessed yeast
[DOI] 10.1371/journal.pgen.1007326 PMC 바로가기 [Article Type] Research Article

Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp .

TLO 중재자 소단위 유전자의 증폭은 칸디다 종에서 필라멘트 성장을 촉진합니다.

Research Article

Published on 2016-10-142022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Activation amplification amplitude ascomycete ascomycetes binding domain bloodstream infection Bloodstream infections Candida Candida albican Candida albicans candidiasis cause cell physiology complex death DNA domain Engineering ENhance environmental cues eukaryotic exhibit facilitated Filamentous fungal fungi gene family Genome genomes genomic growth hallmark individual Infection infections Interaction less mediator mortality rate multitude murine mutant Nuclear localization nuclear localization signal nucleus ortholog overexpressed overexpression pathogenicity phenotype Phenotypes phenotypic plasticity Protein provide reduced regulate subunit Support systemic Candidiasis systemic infection target targets The United States Transcription transcription factor transcription factors transcriptional transcriptional activation unique United States virulence
[DOI] 10.1371/journal.pgen.1006373 PMC 바로가기 [Article Type] Research Article

Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant

대식세포에서 칸디다 알비칸스의 소진화는 필라멘트가 아닌 돌연변이에서 필라멘트를 복원합니다

Research Article

Published on 2014-12-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] addition Antifungal treatment approach avirulent C. albican C. albicans Candida Candida albican Candida albicans Cdk8 Cell cell wall clinical setting complex component Compound connection drug resistance ENCODE environmental cue environmental cues Evolution example exhibited fungi gene encoding growth hosts hyphae hyphal identify in vivo Incubation induce Infection leads Macrophage macrophages maintain mechanism mediator Mediator complex microbe microevolution microevolutionary microorganism microorganisms Missense mutation murine mutant Mutation nucleotide pathogenic pathogenicity phagocytosis regulatory network responsible selection pressure Signaling signaling pathway single nucleotide strain subject the macrophage phagosome These data took place Transcription transcription factor transcription factors transcription regulation transcriptional transcriptional regulation undergo virulence whole genome yeast
[DOI] 10.1371/journal.pgen.1004824 PMC 바로가기 [Article Type] Research Article

miR-199a-5p Is Upregulated during Fibrogenic Response to Tissue Injury and Mediates TGFbeta-Induced Lung Fibroblast Activation by Targeting Caveolin-1

miR-199a-5p는 조직 손상에 대한 섬유성 반응 동안 상향 조절되고 카베올린-1을 표적으로 하여 TGF베타 유도 폐 섬유아세포 활성화를 매개합니다

Research Article

Published on 2013-02-142022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major Activation addition Author best Bile duct Biology Bleomycin CAV1 Cell cell type cellular cellular processes characterized chronic class complex diseases contributing to controls Critical current therapy demonstrated deregulation develop different differentiation disease Disease progression Diseases disorder driving dysregulation ectopic expression Effect expression failure fibroblast fibroblasts fibrosis final common pathway foci form found histologic identify idiopathic Invasion investigated IPF kidney led to life liver Liver fibrosis lung Lung diseases Lung fibrosis Lungs mechanism mediator MicroRNAs Migration miRNA miRNA expression miRNAs morbidity morbidity and mortality mouse model Myofibroblast non-coding RNA Organ failure organ function pathogenic pathogenic mechanism pathogenic mechanisms Patient patients performed poor prognosis proliferation promote pulmonary fibrosis reducing response response rate responsible scar scar tissue Signaling significantly increased strain susceptibility targeting TGFβ therapeutic potency therapeutic strategy thought tissue treat ureteral obstruction
[DOI] 10.1371/journal.pgen.1003291 PMC 바로가기 [Article Type] Research Article