Medical Research Council – Page 8 – Communicable Diseases Research

Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK

Observational Study

Published on 2021-07-012022-10-04
Journal: The Lancet. Respiratory Medicine [Category] 임상,

[키워드] 95% CI A significant reduction accounted Admission all age groups all ethnic groups association assumed both sexes change changed changes in clinical Clinical sign Community Comorbidities Comorbidity confounder COVID-19 Critical care declined defined demographics died dose driver eligible England explained Factors finding First wave funding gradually increased group high risk hospital hospitalised patient identify Illness severity in-hospital mortality Infection ISRCTN registry knowledge Mediation analysis Medical Research Council Mortality multicentre natural effects model non-invasive ventilation Odds ratio Older outcome pandemic Patient patients patients with COVID-19 Primary outcome proportion prospective cohort prospective observational cohort recruited reduction reduction in Registered respiratory Respiratory Support risk RT-PCR test severe disease severity steroid treatment symptoms of COVID-19 the WHO use of steroid WHO with COVID-19
[DOI] 10.1016/S2213-2600(21)00175-2 PMC 바로가기 [Article Type] Observational Study

Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study

Observational Study

Published on 2021-07-012022-10-04
Journal: The Lancet. Infectious Diseases [Category] MERS, SARS, 임상,

[키워드] 95% CI adjusted age American Gastroenterological Association Analysis binary variable BMI BNT162b2 BNT162b2 vaccine ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine chronic Community Comorbidities Comorbidity Control controls COVID COVID-19 vaccine decrease dose Effect Effectiveness Efficacy examined finding first dose foundation Frequency funding health-care individual Infection infection rate infection risk Innovation Lateral flow test Local Local side-effect Medical Research Council obesity occur of BNT162b2 Oxford-AstraZeneca PCR Pfizer-BioNTech Phase 3 trials positive Probability proportion prospective observational study reported risk SARS-CoV-2 SARS-COV-2 infection second dose self-reported systemic Sex shown Side-effect Significant reduction subset systemic tested vaccinated individual vaccination Vaccine Wellcome Trust Zoe Global
[DOI] 10.1016/S1473-3099(21)00224-3 PMC 바로가기 [Article Type] Observational Study

Establishing and operating a ‘virtual ward’ system to provide care for patients with COVID-19 at home: experience from The Gambia

Practice

Published on 2021-06-172022-10-28
Journal: BMJ Global Health [Category] COVID-19, MERS, SARS,

Incorporating oral PrEP into standard prevention services for South African women: a nested interrupted time-series study

남아프리카 여성을위한 표준 예방 서비스에 구강 준비를 통합 : 중첩 된 시계열 연구

Articles

Published on 2021-06-112022-09-06
Journal: The Lancet. HIV [Category] Communicable Disease,

[키워드] 95% CI acquisition adjusted African AIDS Analysis assigned clinical trial clinical trials Contraception contraceptive contraceptive method contraceptives cooperation country decrease determine development eligible Emergency experiment finding Follow-up foundation funding HIV HIV infection HIV prevention incidence incidence rate Intervention Kenya Medical Research Council Melinda Gate Melinda Gates natural experiment nine not used outcome participant plan Population PrEP President Prophylaxis Providing Randomly rate ratio receive Registered relief reported sensitivity analysis Seroconversion South South Africa study visit Swedish These data Trial trials United Nation United Nations United State United States women
[DOI] 10.1016/S2352-3018(21)00048-5 PMC 바로가기 [Article Type] Articles

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

COVID-19로 병원에 입원한 환자의 회복기 혈장(RECOVERY): 무작위 대조, 공개 라벨, 플랫폼 시험

Randomized Controlled Trial

Published on 2021-05-292022-08-13
Journal: Lancet (London, England) [Category] Fulltext, SARS, 임상, 진단, 치료기술,

[키워드] (Medical Research Council 1:1 28-day mortality 95% CI allocation analysed anti-SARS-CoV-2 antibodies assigned clinical outcomes composite endpoint convalescent plasma convalescent plasma group Convalescent plasma therapy COVID-19 therapy death detectable died discharged Efficacy eligible enrolled evaluate finding funding had no hospital hospitalised IMPROVE Innovation intention-to-treat basis Invasive mechanical ventilation ISRCTN Medical Research Council mortality rate ratio NHS no significant difference no significant effect Open-label Patient patients with COVID-19 plasma Platform trial Primary outcome progression proportion randomisation randomised randomised controlled Randomised Evaluation Randomly rate ratio receive recovery Registered SARS-CoV-2 antibodies SARS-CoV-2 antibody significant effect subgroups of patients survival treat treated Treatment Trial two groups usual care usual care alone usual care group with COVID-19
[DOI] 10.1016/S0140-6736(21)00897-7 PMC 바로가기 [Article Type] Randomized Controlled Trial

Ethnic differences in SARS-CoV-2 infection and COVID-19-related hospitalisation, intensive care unit admission, and death in 17 million adults in England: an observational cohort study using the OpenSAFELY platform

Articles

Published on 2021-05-082022-10-30
Journal: Lancet (London, England) [Category] COVID-19, Fulltext, MERS,

[키워드] adjusted adjusted hazard ratio Admission Admissions affected age black Care categories category cause Characteristics clinical factor Comorbidities conducted COVID-19 COVID-19 pandemic death Deprivation Electronic health record England ethnic group finding FIVE funding geographical region group heterogeneity Hospital admissions hospitalisation household size ICU ICU admission increased risk intensive care likelihood mechanism Medical Research Council Model multifactorial multivariable Cox regression Observational cohort study OpenSAFELY outcome platform Population positive positive test result primary care reducing Registered risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 testing second wave Sex Sociodemographic South Asian Stratification study period tested vaccination white
[DOI] 10.1016/S0140-6736(21)00634-6 PMC 바로가기 [Article Type] Articles

Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

Research Paper

Published on 2021-05-082022-10-30
Journal: The Lancet Regional Health - Europe [Category] COVID-19,

[키워드] age Analysis association Cancer Care carried cause causes Characteristics chronic liver disease cohort study Comorbidities contributing to COVID-19 COVID-19 mortality cut-off date database death deaths Deprivation died effort England Epidemiology ethnic group Factor finding funding group higher odd identifying individual Logistic magnitude Male sex Medical conditions Medical Research Council Mortality MOST National NHS notable obesity OpenSAFELY outcomes Oxford patients platform population-based cohort primary care reduce risk Society South unique with COVID-19 working
[DOI] 10.1016/j.lanepe.2021.100109 PMC 바로가기 [Article Type] Research Paper

Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study

Articles

Published on 2021-05-072022-10-29
Journal: The Lancet Rheumatology [Category] COVID-19,

[키워드] 95% CI Acute kidney injury adjust Admission age anti-inflammatory drug clinical Cohort cohort study Community confounding variables covariate COVID-19 COVID-19 severity Critical care death disease disease severity Effect England enrolled funding group groups health-care hospital Hospital admission hospitalised patient identify in-hospital mortality invasive ventilation ISARIC Logistic regression Medical Research Council men Mortality multicentre no significant difference non-invasive ventilation non-steroidal anti-inflammatory drug NSAID NSAIDS Occurrence outcome outcomes oxygen pandemic Patient patients with COVID-19 Policy populations Primary outcome propensity score matching prospective cohort study required Result rheumatological SARS-COV-2 infection secondary outcome severity severity of COVID-19 suggested supplementary oxygen variables were recorded women
[DOI] 10.1016/S2665-9913(21)00104-1 PMC 바로가기 [Article Type] Articles

Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study

Observational Study

Published on 2021-05-012022-10-04
Journal: Lancet (London, England) [Category] Fulltext, MERS, 임상,

[키워드] 95% CI age Analysis association BNT162b2 mRNA BNT162b2 mRNA vaccine ChAdOx1 nCoV-19 ChAdOx1 vaccine challenge clinical trial COVID-19 COVID-19 vaccination COVID-19 vaccine Cox model defined disease Effect Effectiveness Efficacy enhanced finding first dose funding Hospital admission individual Industrial Innovation Interim mass Medical Research Council National Older Patient Pfizer–BioNTech Phase 3 Poisson regression model positive primary care prospective cohort study reduced Registered residual confounding Result reverse transcription-PCR risk shown Strategy study period substantial reduction tested vaccination Vaccine were excluded
[DOI] 10.1016/S0140-6736(21)00677-2 PMC 바로가기 [Article Type] Observational Study

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

COVID-19로 병원에 입원한 환자의 토실리주맙(RECOVERY): 무작위, 통제, 공개 라벨, 플랫폼 시험

Clinical Trial

Published on 2021-05-012022-08-13
Journal: Lancet (London, England) [Category] Fulltext, SARS, 임상, 진단,

[키워드] (Medical Research Council 1:1 28-day mortality 95% CI Adult patients baseline benefit C-reactive protein clinical outcomes composite endpoint Corticosteroids COVID-19 therapy death died discharged dose eligible enrolled evaluate the effect Evidence evidence of finding funding hospital hospitalised hospitalised COVID-19 patient hospitalised COVID-19 patients hypoxia Innovation intention-to-treat population intravenously Invasive mechanical ventilation ISRCTN less Medical Research Council not improved Open-label oxygen oxygen saturation Oxygen therapy Patient Platform trial Primary outcome random assignment randomised Randomised Evaluation rate ratio receiving RECOVERY trial Registered respiratory Respiratory Support risk risk ratio second dose Standard of care subgroups of patients survival systemic corticosteroids systemic inflammation the patient Tocilizumab Treatment Trial trial participant usual care weight with COVID-19
[DOI] 10.1016/S0140-6736(21)00676-0 PMC 바로가기 [Article Type] Clinical Trial