mendelian randomization – Page 8 – Communicable Diseases Research

Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study

Research

Published on 2021-12-242022-10-30
Journal: Journal of Translational Medicine [Category] COVID-19,

Genetically Predicted Higher Educational Attainment Decreases the Risk of COVID-19 Susceptibility and Severity: A Mendelian Randomization Study

Public Health

Published on 2021-12-232022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS,

Identifying Putative Causal Links between MicroRNAs and Severe COVID-19 Using Mendelian Randomization

멘델식 무작위화를 사용하여 MicroRNA와 심각한 COVID-19 사이의 추정 인과 관계 식별

Article

Published on 2021-12-112022-09-11
Journal: Cells [Category] SARS, 바이오마커,

[키워드] approaches assessment Biomarker Biomarkers canonical Causal causal relationship Causality caused circulating circulating miRNA circulating miRNAs COVID-19 COVID-19 case COVID-19 cases COVID-19 severity death diagnose early treatment Effect eQTL evaluated expression data group GWAS summary statistics help identify identifying imperative IMPROVE independent investigated measure mendelian randomization microRNA miRNA miRNA biomarker miRNA expression miRNAs Multiple Multiple studies outcomes pandemic phenotype Prognosis provide retrieved risk Risk assessment risk assessments SARS-CoV-2 severe cases severe COVID-19 shown unique with COVID-19
[DOI] 10.3390/cells10123504 PMC 바로가기 [Article Type] Article

Extensive Mendelian randomization study identifies potential causal risk factors for severe COVID-19

Research

Published on 2021-12-092022-10-05
Journal: Communications Medicine [Category] 바이오마커, 유전자 메커니즘, 치료법,

Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study

멘델식 무작위 배정 연구에서 지질 저하 약물과 COVID-19 결과의 연관성

Research Article

Published on 2021-12-062022-09-10
Journal: eLife [Category] 변종, 신약개발, 치료제,

[키워드] 95% CI 95% confidence interval Analysis approach association associations benefit Blood calculate carried causal relationship caused cholesterol clinical trial confounding bias COVID-19 COVID-19 hospitalization COVID-19 pandemic death decrease drug drugs eLife estimates Evidence expression expression quantitative trait loci faster fat funding genetic instrument genetic instruments Genetic variant genetic variants Genome-wide association study higher risk HMGCR Hospitalization Hospitalized Human Hypothesis identify in viral infected with SARS-CoV-2 Infection infections LDL cholesterol Lipid lipid metabolism lipid-lowering drugs loci low-density Low-density lipoprotein mendelian randomization Mendelian randomization studies Mendelian randomization study metabolism Mortality MR study NPC1L1 Odds ratio outcome Patient PCSK9 positive protective effect Quantitative reduce reduced risk SARS-CoV-2 SARS-COV-2 infection severe disease SMR statins suggested susceptibility target gene Target genes treating COVID-19 university variable Viral viral infections virus were used with COVID-19
[DOI] 10.7554/eLife.73873 PMC 바로가기 [Article Type] Research Article

Genetic predisposition to COVID-19 may increase the risk of hypertension disorders in pregnancy: A two-sample Mendelian randomization study

Research article

Published on 2021-12-012022-10-05
Journal: Pregnancy hypertension [Category] SARS, 유전자 메커니즘,

Carnitine and COVID-19 Susceptibility and Severity: A Mendelian Randomization Study

Nutrition

Published on 2021-11-252022-10-31
Journal: Frontiers in Nutrition [Category] COVID-19,

Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study

Original Research Article

Published on 2021-11-192022-10-30
Journal: JRSM Cardiovascular Disease [Category] COVID-19,

[키워드] association blood pressure BMI body mass index CAD cardiovascular cardiovascular disease cardiovascular risk cardiovascular risk factors Causal confidence interval Confidence intervals controls Coronary artery disease COVID-19 COVID-19 diagnosis determine Diagnosis diagnosis of COVID-19 Evidence examined genome-wide association GWAS GWAS meta-analysis Health Hospital admission Hospitalization increase in Laboratory mendelian randomization Meta-analysis observational study Odds ratio performed predicted reported residual confounding Result risk risk factor severe COVID-19 severity severity of COVID-19 Socioeconomic factor type 2 diabete with COVID-19
[DOI] 10.1177/20480040211059374 PMC 바로가기 [Article Type] Original Research Article

Estimating causal effects of atherogenic lipid-related traits on COVID-19 susceptibility and severity using a two-sample Mendelian randomization approach

두 샘플 멘델 리안 무작위 화 접근법을 사용한 CovID-19 감수성 및 심각성에 대한 죽상 성 지질 관련 특성의 인과 적 영향 추정

Research

Published on 2021-11-132022-09-10
Journal: BMC Medical Genomics [Category] MERS, SARS, 유전자 메커니즘,

[키워드] 95% CI 95% confidence interval analyses Apolipoprotein B approach bidirectional Bonferroni correction cholesterol conducted controls COVID-19 COVID-19 severity COVID-19 susceptibility dataset death Effect European European population Genome-wide association study greater GWAS GWAS dataset GWAS meta-analyses GWAS meta-analysis higher risk horizontal pleiotropy Hospitalization increase in indicate initiative IVW LDL-cholesterol low-density Low-density lipoprotein mechanism mechanisms mendelian randomization MR analysis MR study MR-Egger regression MR-PRESSO Multivariable MR Odds ratio outcome p value participant performed PhenoScanner Result reverse causation risk risk factor Risk factors risk of COVID-19 SARS-CoV-2 Sensitivity analyses sensitivity analysis serum severity significantly Standard deviation statistically significant suggested supplementary material the disease Triglyceride UK biobank unlikely weighted median weighted mode with COVID-19
[DOI] 10.1186/s12920-021-01127-2 PMC 바로가기 [Article Type] Research

Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study

Covid-19에서 신장 기능의 역할을 이해하기 위해 유전학을 사용하여 : Mendelian Randomization Study

Research Article

Published on 2021-11-132022-09-10
Journal: BMC Nephrology [Category] MERS, SARS, 변종, 신약개발, 진단,

[키워드] 95% confidence interval appear cause Cohort controls COVID-19 COVID-19 hospitalization COVID-19 mortality COVID-19 treatment creatinine dysfunction EGFR estimated glomerular filtration rate estimates examined filtration rate Genetic variant genetics genome-wide significant genotyping glomerular filtration rate IMPROVE indication Infection Intervention kidney dysfunction Kidney function lower risk medication mendelian randomization observational studies observational study occur Odds ratio open predict randomization Result severe COVID-19 supplementary material Symptom target Treatment Urine urine albumin
[DOI] 10.1186/s12882-021-02586-6 PMC 바로가기 [Article Type] Research Article